Herranz Lab
@herranzlab.bsky.social
Associate Professor working on Leukemia @rutgerscancer.bsky.social | PharmD @ucm.es | PhD @CNIOStopCancer.bsky.social | Postdoc @columbiauniversity.bsky.social. Posts=my views alone.
Had tons of fun visiting the University of Zurich Children’s Hospital and discussing our science with new and old friends @ninacabezas.bsky.social Thanks so much for the invitation #MorscherLab
September 11, 2025 at 7:54 PM
Had tons of fun visiting the University of Zurich Children’s Hospital and discussing our science with new and old friends @ninacabezas.bsky.social Thanks so much for the invitation #MorscherLab
Get in touch with your representatives! #NIH #KeepUpTheGoodFight
May 7, 2025 at 6:21 PM
Get in touch with your representatives! #NIH #KeepUpTheGoodFight
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
March 26, 2025 at 4:50 PM
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...
March 21, 2025 at 3:49 PM
Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...
Harold Varmus and STOP F/ELON
March 7, 2025 at 5:29 PM
Harold Varmus and STOP F/ELON
March 7, 2025 at 5:12 PM
The @herranzlab.bsky.social will be present at the @standupforscience.bsky.social rallies both in Trenton and NYC! I personally hope to see many of my NY friends at Washington Square Park, fighting the right fight 💪🏽
March 6, 2025 at 12:24 AM
The @herranzlab.bsky.social will be present at the @standupforscience.bsky.social rallies both in Trenton and NYC! I personally hope to see many of my NY friends at Washington Square Park, fighting the right fight 💪🏽
Overall, our findings unveil a MYC-ACLY loop in which ACLY promotes MYC expression by providing the acetyl-CoA units needed for its epigenetic regulation, while MYC itself binds to the ACLY promoter and transcriptionally activates it, resulting in a feedforward loop supports T-ALL growth
January 21, 2025 at 2:18 PM
Overall, our findings unveil a MYC-ACLY loop in which ACLY promotes MYC expression by providing the acetyl-CoA units needed for its epigenetic regulation, while MYC itself binds to the ACLY promoter and transcriptionally activates it, resulting in a feedforward loop supports T-ALL growth
Finally, using an ACLY pharmacological inhibitor, we showed consistent downregulation of MYC in human T-ALL cells , which even translated into increased survival in a human T-ALL PDX in vivo
January 21, 2025 at 2:15 PM
Finally, using an ACLY pharmacological inhibitor, we showed consistent downregulation of MYC in human T-ALL cells , which even translated into increased survival in a human T-ALL PDX in vivo
Reverse gene set enrichment analyses using our signature upon genetic loss of MYC revealed a similarly enriched signature upon ACLY loss, suggesting ACLY could also be upstream of MYC. Indeed, luciferase reporter assays confirmed MYC regulates ACLY, and MYC loss in T-ALL led to reduced ACLY levels
January 21, 2025 at 2:14 PM
Reverse gene set enrichment analyses using our signature upon genetic loss of MYC revealed a similarly enriched signature upon ACLY loss, suggesting ACLY could also be upstream of MYC. Indeed, luciferase reporter assays confirmed MYC regulates ACLY, and MYC loss in T-ALL led to reduced ACLY levels
Transcriptional profiling upon acute ACLY loss revealed a transcritpional programmed governed by MYC downregulation. Indeed, ACLY loss led to a drastic reduction in MYC protein levels, and epigenetic profiling showed this is likely driven by severely reduced H3K27ac levels in the MYC promoter
January 21, 2025 at 2:11 PM
Transcriptional profiling upon acute ACLY loss revealed a transcritpional programmed governed by MYC downregulation. Indeed, ACLY loss led to a drastic reduction in MYC protein levels, and epigenetic profiling showed this is likely driven by severely reduced H3K27ac levels in the MYC promoter
Interestingly, ACLY loss is completely dispensable for normal T-cell development. Next, analyses upon acute ACLY loss in T-ALL in vivo revealed a metabolic crisis with reduced acetyl-CoA levels, acumulation of AICAR and likely blocks in glycolysis, glutaminolysis and nucletotide synthesis
January 21, 2025 at 2:09 PM
Interestingly, ACLY loss is completely dispensable for normal T-cell development. Next, analyses upon acute ACLY loss in T-ALL in vivo revealed a metabolic crisis with reduced acetyl-CoA levels, acumulation of AICAR and likely blocks in glycolysis, glutaminolysis and nucletotide synthesis
We first identified ACLY as downregulated upon NOTCH1 inhihibiton and overexpressed in T-ALL patients. Thus, we generated NOTCH1-induced ACLY conditional knockout primary leukemias and we observed significant antileukemic effects upon secondart ACLY loss in established leukemias in vivo
January 21, 2025 at 2:06 PM
We first identified ACLY as downregulated upon NOTCH1 inhihibiton and overexpressed in T-ALL patients. Thus, we generated NOTCH1-induced ACLY conditional knockout primary leukemias and we observed significant antileukemic effects upon secondart ACLY loss in established leukemias in vivo
Happy holidays from the @herranzlab.bsky.social (and the #Grinch 😅)!
December 19, 2024 at 6:02 PM
Happy holidays from the @herranzlab.bsky.social (and the #Grinch 😅)!
I for one will not be looking forward to #ASH25 in Orlando…much better San Diego @ash-hematology.bsky.social
December 8, 2024 at 7:45 PM
I for one will not be looking forward to #ASH25 in Orlando…much better San Diego @ash-hematology.bsky.social
Stellar talk from @dasilva-diz.bsky.social in the @herranzlab.bsky.social at #ASH24 presenting her recently accepted paper in #BloodNeoplasia @bloodportfolio.bsky.social @rutgerscancer.bsky.social!! #ProudPI
December 7, 2024 at 12:33 AM
Stellar talk from @dasilva-diz.bsky.social in the @herranzlab.bsky.social at #ASH24 presenting her recently accepted paper in #BloodNeoplasia @bloodportfolio.bsky.social @rutgerscancer.bsky.social!! #ProudPI