Quentin Herail
@herailquentin.bsky.social
PhD Student in Hugonnet Lab 🧫
Reposted by Quentin Herail
Proud of our new study out in @cp-cellreports.bsky.social!
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky
Role of endopeptidases in lateral cell wall expansion in Escherichia coli
Peptidoglycan, the major constituent of bacterial cell walls, is a giant macromolecule made of glycan strands cross-linked by short peptides, which pr…
www.sciencedirect.com
October 8, 2025 at 2:54 PM
Proud of our new study out in @cp-cellreports.bsky.social!
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky
Reposted by Quentin Herail
Thrilled to announce our new paper with M. Ethève-Quelquejeu's lab @upcite.bsky.social published @chemistryeurope.bsky.social! We report on the synthesis, and testing by HRMS, of new β-lactam prodrugs, a proof of concept for designing drugs targetting specifically β-lactamase-producing pathogens.
Optimization of Prodrug Activation by Enzymatic Cleavage of the β‐lactam Ring of Carbapenems
We report synthetic routes that yield prodrugs consisting of two carbapenems connected by benzyl carbonate linkers. A mass spectrometry assay was elaborated to monitor, in a single kinetic experiment...
doi.org
July 25, 2025 at 1:15 PM
Thrilled to announce our new paper with M. Ethève-Quelquejeu's lab @upcite.bsky.social published @chemistryeurope.bsky.social! We report on the synthesis, and testing by HRMS, of new β-lactam prodrugs, a proof of concept for designing drugs targetting specifically β-lactamase-producing pathogens.
Reposted by Quentin Herail
Check out our study on combination of amox, imi and relebactam to treat M. abscessus!
Our findings constitute the basis for a clinical consideration of this treatment. This could be consequential for treating infections in cystic fibrosis patients
@vaincrelamuco.bsky.social
doi.org/10.1093/jac/...
Our findings constitute the basis for a clinical consideration of this treatment. This could be consequential for treating infections in cystic fibrosis patients
@vaincrelamuco.bsky.social
doi.org/10.1093/jac/...
In vitro, intracellular and in vivo synergy between amoxicillin, imipenem and relebactam against Mycobacterium abscessus
AbstractObjectives. Mycobacterium abscessus is the most frequent of the rapidly growing mycobacteria responsible for lung infections in patients suffering
doi.org
April 16, 2025 at 10:33 AM
Check out our study on combination of amox, imi and relebactam to treat M. abscessus!
Our findings constitute the basis for a clinical consideration of this treatment. This could be consequential for treating infections in cystic fibrosis patients
@vaincrelamuco.bsky.social
doi.org/10.1093/jac/...
Our findings constitute the basis for a clinical consideration of this treatment. This could be consequential for treating infections in cystic fibrosis patients
@vaincrelamuco.bsky.social
doi.org/10.1093/jac/...