htw
@heniek-htw.bsky.social
Look deep, patiently into nature & then you will understand everything better.
#Depression severity in adolescents correlates with #circadian desynchronization. These findings reveal the potential value of PER and SCN-OFC connectivity as biomarkers for MDD in adolescents.
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November 22, 2025 at 6:54 PM
#Depression severity in adolescents correlates with #circadian desynchronization. These findings reveal the potential value of PER and SCN-OFC connectivity as biomarkers for MDD in adolescents.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Light-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome
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November 22, 2025 at 6:44 PM
Light-induced conformational switching and magnetic sensitivity of Drosophila cryptochrome
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• We did a systematic review of seasons/gravity/geomagnetism affecting brain function
• We found evidence across both animal and human literature supporting the premise
• Evidence is, however, primarily behavioral, with inadequate mechanistic insights
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• We found evidence across both animal and human literature supporting the premise
• Evidence is, however, primarily behavioral, with inadequate mechanistic insights
www.sciencedirect.com/science/arti...
November 22, 2025 at 2:54 PM
• We did a systematic review of seasons/gravity/geomagnetism affecting brain function
• We found evidence across both animal and human literature supporting the premise
• Evidence is, however, primarily behavioral, with inadequate mechanistic insights
www.sciencedirect.com/science/arti...
• We found evidence across both animal and human literature supporting the premise
• Evidence is, however, primarily behavioral, with inadequate mechanistic insights
www.sciencedirect.com/science/arti...
Incorporating the #circadian context has not only clarified the IL-10 role in IAV infection but also underscored the pivotal #influence of circadian regulation on #immune responses.
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November 22, 2025 at 1:59 PM
Incorporating the #circadian context has not only clarified the IL-10 role in IAV infection but also underscored the pivotal #influence of circadian regulation on #immune responses.
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This review aimed to elucidate the physiological mechanisms underlying exercise-induced #sleep improvements and assess its potential as a sustainable, low-risk alternative to pharmacotherapy in insomnia management.
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November 22, 2025 at 1:58 PM
This review aimed to elucidate the physiological mechanisms underlying exercise-induced #sleep improvements and assess its potential as a sustainable, low-risk alternative to pharmacotherapy in insomnia management.
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From symptoms to systems: A comprehensive review of the clinical utility of classic and novel approaches to major #depression subtyping
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November 22, 2025 at 1:56 PM
From symptoms to systems: A comprehensive review of the clinical utility of classic and novel approaches to major #depression subtyping
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The role of circadian rhythms is emerging as a contributor to healthy aging, with studies ranging from behavioral to molecular rhythms. In this review, we provide a summary of what is known about behavioral and systemic physiology rhythms with aging in humans.
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November 22, 2025 at 1:54 PM
The role of circadian rhythms is emerging as a contributor to healthy aging, with studies ranging from behavioral to molecular rhythms. In this review, we provide a summary of what is known about behavioral and systemic physiology rhythms with aging in humans.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Ginsenoside Re binds Drp1 Leu94 across species to restore mitochondrial homeostasis via Atg1/ULK1-dependent fission-mitophagy coupling in age-related degeneration
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November 22, 2025 at 1:47 PM
Ginsenoside Re binds Drp1 Leu94 across species to restore mitochondrial homeostasis via Atg1/ULK1-dependent fission-mitophagy coupling in age-related degeneration
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Both persistently long and short #sleep duration trajectories are associated with an elevated risk of #sarcopenia, compared to persistently high-normal sleep duration trajectories among middle-aged and older Chinese adults.
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November 22, 2025 at 1:45 PM
Both persistently long and short #sleep duration trajectories are associated with an elevated risk of #sarcopenia, compared to persistently high-normal sleep duration trajectories among middle-aged and older Chinese adults.
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Long-term CoQ10 supplementation ameliorates weight gain, white adipocyte hypertrophy and inflammation in WAT, and metabolic disorders caused by combined estrogen deficiency and HFD, likely through its WAT browning effect.
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November 22, 2025 at 11:06 AM
Long-term CoQ10 supplementation ameliorates weight gain, white adipocyte hypertrophy and inflammation in WAT, and metabolic disorders caused by combined estrogen deficiency and HFD, likely through its WAT browning effect.
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This review aims to comprehensively summarize the underlying molecular mechanisms by which the cGAS-STING pathway regulates cellular senescence and aging.
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November 22, 2025 at 11:02 AM
This review aims to comprehensively summarize the underlying molecular mechanisms by which the cGAS-STING pathway regulates cellular senescence and aging.
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The evidence suggests that TRE may modestly reduce TG levels, particularly in overweight individuals, with a limited impact on LDL-C, HDL-C, and TC. ADF demonstrated inconsistent effects on lipid profile. RIF presented modest improvements of TG and HDL-C.
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November 21, 2025 at 4:46 PM
The evidence suggests that TRE may modestly reduce TG levels, particularly in overweight individuals, with a limited impact on LDL-C, HDL-C, and TC. ADF demonstrated inconsistent effects on lipid profile. RIF presented modest improvements of TG and HDL-C.
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Central regulation of the heart in type 2 diabetes mellitus
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November 20, 2025 at 7:44 AM
Central regulation of the heart in type 2 diabetes mellitus
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This review provides an overview of the advances in the last five years in the #anticancer activity of #melatonin in combination with synthetic drugs and natural products.
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November 17, 2025 at 7:11 PM
This review provides an overview of the advances in the last five years in the #anticancer activity of #melatonin in combination with synthetic drugs and natural products.
www.sciencedirect.com/science/arti...
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The intestinal clock shapes the diurnal sleep-wake cycle through temporally gating glutamine homeostasis and serves as a potential target for boosting the sleep rhythm and for managing sleep disorders.
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November 17, 2025 at 7:02 PM
The intestinal clock shapes the diurnal sleep-wake cycle through temporally gating glutamine homeostasis and serves as a potential target for boosting the sleep rhythm and for managing sleep disorders.
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Body Mass Index, Gray Matter Volume and peripheral inflammation in patients with post-COVID condition
BMI contributes to GMV alterations in PCC patients, with both BMI and GMV demonstrating correlations with peripheral immunological markers.
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BMI contributes to GMV alterations in PCC patients, with both BMI and GMV demonstrating correlations with peripheral immunological markers.
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November 8, 2025 at 6:25 PM
Body Mass Index, Gray Matter Volume and peripheral inflammation in patients with post-COVID condition
BMI contributes to GMV alterations in PCC patients, with both BMI and GMV demonstrating correlations with peripheral immunological markers.
www.sciencedirect.com/science/arti...
BMI contributes to GMV alterations in PCC patients, with both BMI and GMV demonstrating correlations with peripheral immunological markers.
www.sciencedirect.com/science/arti...
This review integrates current evidence on three dietary polyphenols, quercetin, allicin, and ferulic acid, that strengthen intestinal barrier integrity, remodel gut microbiota, and modulate neuroinflammatory cascades through antioxidant, anti-inflammatory, and gene-regulatory pathways.
November 7, 2025 at 7:18 AM
This review integrates current evidence on three dietary polyphenols, quercetin, allicin, and ferulic acid, that strengthen intestinal barrier integrity, remodel gut microbiota, and modulate neuroinflammatory cascades through antioxidant, anti-inflammatory, and gene-regulatory pathways.
Redox state is similar in subjects following omnivorous, vegan, vegetarian and low-carbohydrate high-fat diet
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November 7, 2025 at 7:11 AM
Redox state is similar in subjects following omnivorous, vegan, vegetarian and low-carbohydrate high-fat diet
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Multi-omics profiling reveals that time-restricted feeding improves metabolic health in HFHFD-fed mice independent of weight loss by enhancing iWAT thermogenesis through mitochondrial OXPHOS, with specific upregulation of ETC complex I proteins.
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November 7, 2025 at 7:09 AM
Multi-omics profiling reveals that time-restricted feeding improves metabolic health in HFHFD-fed mice independent of weight loss by enhancing iWAT thermogenesis through mitochondrial OXPHOS, with specific upregulation of ETC complex I proteins.
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•BPA exposure during pregnancy causes enterotoxicity in mice;
•Pineal melatonin ameliorates BPA exposure-induced enterotoxicity;
•Pineal melatonin exerts ameliorative effects by modulating the tryptophan/AhR/mitochondria pathway.
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•Pineal melatonin ameliorates BPA exposure-induced enterotoxicity;
•Pineal melatonin exerts ameliorative effects by modulating the tryptophan/AhR/mitochondria pathway.
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November 6, 2025 at 2:55 PM
•BPA exposure during pregnancy causes enterotoxicity in mice;
•Pineal melatonin ameliorates BPA exposure-induced enterotoxicity;
•Pineal melatonin exerts ameliorative effects by modulating the tryptophan/AhR/mitochondria pathway.
www.sciencedirect.com/science/arti...
•Pineal melatonin ameliorates BPA exposure-induced enterotoxicity;
•Pineal melatonin exerts ameliorative effects by modulating the tryptophan/AhR/mitochondria pathway.
www.sciencedirect.com/science/arti...
•Outdoor ALAN exposure was related to shorter TL in children and adolescents.
•The effect of ALAN on TL was more evident in boys than girls.
•No significant association was observed between ALAN and mtDNAcn.
•Environmental light exposure may play a role in cellular aging.
•The effect of ALAN on TL was more evident in boys than girls.
•No significant association was observed between ALAN and mtDNAcn.
•Environmental light exposure may play a role in cellular aging.
November 6, 2025 at 2:48 PM
•Outdoor ALAN exposure was related to shorter TL in children and adolescents.
•The effect of ALAN on TL was more evident in boys than girls.
•No significant association was observed between ALAN and mtDNAcn.
•Environmental light exposure may play a role in cellular aging.
•The effect of ALAN on TL was more evident in boys than girls.
•No significant association was observed between ALAN and mtDNAcn.
•Environmental light exposure may play a role in cellular aging.
•Morning types demonstrated higher diet quality, greater eating awareness.
•Morning types had lower eating and social jetlag.
•Greater eating jetlag was linked to longer eating windows and higher social jetlag.
•Mindful eating was inversely, and hedonic hunger positively, linked to obesity.
•Morning types had lower eating and social jetlag.
•Greater eating jetlag was linked to longer eating windows and higher social jetlag.
•Mindful eating was inversely, and hedonic hunger positively, linked to obesity.
November 6, 2025 at 9:45 AM
•Morning types demonstrated higher diet quality, greater eating awareness.
•Morning types had lower eating and social jetlag.
•Greater eating jetlag was linked to longer eating windows and higher social jetlag.
•Mindful eating was inversely, and hedonic hunger positively, linked to obesity.
•Morning types had lower eating and social jetlag.
•Greater eating jetlag was linked to longer eating windows and higher social jetlag.
•Mindful eating was inversely, and hedonic hunger positively, linked to obesity.
TAN ameliorates UC by upregulating BMAL1-dependent inflammation suppression and barrier integrity enhancement. This study underscores circadian clock modulation as promising strategy for UC management and provides mechanistic foundation for optimizing timed dosing regimens in clinical translation
November 6, 2025 at 9:44 AM
TAN ameliorates UC by upregulating BMAL1-dependent inflammation suppression and barrier integrity enhancement. This study underscores circadian clock modulation as promising strategy for UC management and provides mechanistic foundation for optimizing timed dosing regimens in clinical translation
We review findings describing the circadian regulation of the host response to infection, the circadian metabolic adaptations occurring during host–microbiota–pathogen interactions and how such regulation can influence the immune response of the host and, ultimately, its own survival.
November 6, 2025 at 9:40 AM
We review findings describing the circadian regulation of the host response to infection, the circadian metabolic adaptations occurring during host–microbiota–pathogen interactions and how such regulation can influence the immune response of the host and, ultimately, its own survival.
• rTMS has a behavioral antidepressant effect in CUMS rat model of depression.
• 10 Hz rTMS reduces dopamine D2 receptors in the striatum of depressive-like rats.
• No changes in TH in the prefrontal cortex and dorsal striatum after rTMS.
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• 10 Hz rTMS reduces dopamine D2 receptors in the striatum of depressive-like rats.
• No changes in TH in the prefrontal cortex and dorsal striatum after rTMS.
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November 5, 2025 at 5:49 PM
• rTMS has a behavioral antidepressant effect in CUMS rat model of depression.
• 10 Hz rTMS reduces dopamine D2 receptors in the striatum of depressive-like rats.
• No changes in TH in the prefrontal cortex and dorsal striatum after rTMS.
www.sciencedirect.com/science/arti...
• 10 Hz rTMS reduces dopamine D2 receptors in the striatum of depressive-like rats.
• No changes in TH in the prefrontal cortex and dorsal striatum after rTMS.
www.sciencedirect.com/science/arti...