Lightnews — Scholar-powered news

@helgapill.bsky.social

610 followers 1.8K following 140 posts

pharmacist

Posts Replies Media Videos

Reposted

Chise

@sailorrooscout.bsky.social

Current treatments require repeated injections directly into the eye, but this vaccine can be delivered intramuscularly, making it less invasive and easier to administer.

The study has been published in Vaccine. YES, it is PEER-REVIEWED.
• www.sciencedirect.com/science/arti...

🧪🧵⬇️

Summary
A new mRNA vaccine developed in Japan has been shown to suppress abnormal blood vessel growth in the retina of mice, offering hope for patients with age-related macular degeneration (AMD). Current treatments require repeated injections directly into the eye, but this vaccine can be delivered intramuscularly, making it less invasive and easier to administer.
By targeting LRG1, a protein linked to abnormal angiogenesis, the vaccine triggered strong antibody responses that reduced retinal damage by up to 85% in mouse models. If successful in humans, this approach could transform AMD treatment and significantly reduce the burden of eye injections.
Key Facts
Mechanism
The vaccine blocks LRG1, a protein promoting abnormal blood vessel growth.
Effectiveness
Reduced retinal leakage by 85% and lesion size by 82% in mouse models.
Advantage
Works as well as anti-VEGF therapy but requires only a simple arm injection.
Source
Institute of Science Tokyo

November 2, 2025 at 5:02 PM

Reposted

Henning

@henningt6.bsky.social

Eric Topol hat einen interessanten Artikel zu neuen Erkenntnissen zu den "Wächtern des Gehirns" geschrieben.

Die dort beschriebenen neuen Erkenntnisse zur "(Nicht-) Immunität" des Gehirns machen klar, dass wir Aussagen zur Folgenlosigkeit von Coronainfektionen derzeit GAR NICHT machen können.