Harshit Sahay
@harshitsahay.bsky.social
Computational biology, cancer genomics, gene regulation and machine learning.
Postdoc @ MSKCC, previously @Duke
Postdoc @ MSKCC, previously @Duke
Reposted by Harshit Sahay
'Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the primary initiator of eukaryotic mismatch repair'
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
DNA mutagenesis driven by transcription factor competition with mismatch repair
Competition between transcription factors and mismatch repair machinery drives localized
hypermutation at regulatory elements, with implications for cancer and genome evolution.
www.cell.com
July 30, 2025 at 6:08 AM
'Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the primary initiator of eukaryotic mismatch repair'
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Harshit Sahay
We're excited to release 𝐦𝐑𝐍𝐀𝐁𝐞𝐧𝐜𝐡, a new benchmark suite for mRNA biology containing 10 diverse datasets with 59 prediction tasks, evaluating 18 foundation model families.
Paper: biorxiv.org/content/10.1...
GitHub: github.com/morrislab/mR...
Blog: blank.bio/post/mrnabench
Paper: biorxiv.org/content/10.1...
GitHub: github.com/morrislab/mR...
Blog: blank.bio/post/mrnabench
July 15, 2025 at 6:41 PM
We're excited to release 𝐦𝐑𝐍𝐀𝐁𝐞𝐧𝐜𝐡, a new benchmark suite for mRNA biology containing 10 diverse datasets with 59 prediction tasks, evaluating 18 foundation model families.
Paper: biorxiv.org/content/10.1...
GitHub: github.com/morrislab/mR...
Blog: blank.bio/post/mrnabench
Paper: biorxiv.org/content/10.1...
GitHub: github.com/morrislab/mR...
Blog: blank.bio/post/mrnabench
Reposted by Harshit Sahay
Please check out our new approach to modeling somatic mutation signatures.
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
Damage and Misrepair Signatures: Compact Representations of Pan-cancer Mutational Processes
Mutational signatures of single-base substitutions (SBSs) characterize somatic mutation processes which contribute to cancer development and progression. However, current mutational signatures do not ...
www.biorxiv.org
June 3, 2025 at 12:34 AM
Please check out our new approach to modeling somatic mutation signatures.
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...
DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪
www.biorxiv.org/content/10.1...