hansenjn
@hansenjn.bsky.social
Shedding light on #cilia, #flagella, and subcellular biology. Developing open-source image analysis for subcellular structures and whole cells (adipocytes, #microglia, #macrophage, and all kinds of other cells): CiliaQ, SpermQ, AdipoQ, MotiQ, FreQ, ...
CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....
October 31, 2025 at 5:14 PM
CiliaQ Editor just received a convenient upgrade allowing to faster inspect and correct segmentations of #cilia in the #CiliaQ workflow (automatic color & BC adjustment, new functions, etc.). If you update FIJI, you automatically update to the new version. All details at github.com/hansenjn/Cil....
So proud and happy to share that our study on the #proteome, heterogeneity, and cell-type specificity of primary #cilia is published now at Cell 🎉
Big thank you to all the many people that made this possible, at the Lundberg Lab, Human Protein Atlas, Lindstrand lab, and Hsien-Sheu lab.
Big thank you to all the many people that made this possible, at the Lundberg Lab, Human Protein Atlas, Lindstrand lab, and Hsien-Sheu lab.
Now online! Intrinsic heterogeneity of primary cilia revealed through spatial proteomics
Intrinsic heterogeneity of primary cilia revealed through spatial proteomics
An antibody-based spatial proteomics screen on human primary cilia explores 715 proteins across single cilia of different cell types and reveals extensive cell-type specificity, single-cilium heterogeneity, ciliary microdomains, CFAP300 as a new cilium marker protein, 91 novel proteins including CREB3, and a CREB3 variant associated to ciliopathy phenotypes.
dlvr.it
September 27, 2025 at 5:28 PM
Reposted by hansenjn
In the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna.
www.proteinatlas.org/news/2025-09...
www.proteinatlas.org/news/2025-09...
September 25, 2025 at 4:50 PM
In the journal Cell a deep analysis of the HPA primary cilia section is published. The primary cilia is portrayed as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, inspiring new views on this tiny antenna.
www.proteinatlas.org/news/2025-09...
www.proteinatlas.org/news/2025-09...
Reposted by hansenjn
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade
Ascorbate peroxidase (APEX) is a versatile labeling enzyme used for live-cell proteomics at high spatial and temporal resolution. However, toxicity of its substrate hydrogen peroxide and background la...
www.biorxiv.org
January 11, 2025 at 7:51 PM
Proud to share our work spear-headed by PhD student Tommy Sroka with major contributions by #xenopus expert Kerstin Feistel.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Our iAPEX #ProximityLabeling method for #MassSpec based subcellular #proteomics works by locally generating H2O2 using a D-amino acid oxidase that activates APEX2 in situ.
Reposted by hansenjn
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1
December 30, 2024 at 5:25 PM
Calendars out- just over two weeks until our 🎉50th🥳 @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium 14/01/2025 15:00-17:30- everything hot in #cilia #centrosomes free & open to all! Register to access this 🔥 series: www.eventbrite.co.uk/e/bscb-genso... /1