Hans Carolus
@hanscarolus.bsky.social
Molecular microbiologist fascinated by evolution and neglected pathogens. Postdoc at KU Leuven. Distiller of jenever. I unconditionally love yeast, one gave me a job, another gave me a hobby.
Reposted by Hans Carolus
Out now in Nature: A polyene macrolide targeting phospholipids in the fungal cell membrane
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A polyene macrolide targeting phospholipids in the fungal cell membrane - Nature
Mandimycin, a polyene macrolide, exhibits strong antifungal activity and possesses a mode of action that is distinct from other compounds of this class.
www.nature.com
March 21, 2025 at 1:10 PM
Out now in Nature: A polyene macrolide targeting phospholipids in the fungal cell membrane
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hans Carolus
Rapid spread of #Candida auris in China after COVID-19 - Journal of Infection www.journalofinfection.com/article/S016...
Rapid spread of Candida auris in China after COVID-19
Dear Editor
www.journalofinfection.com
March 22, 2025 at 3:53 AM
Rapid spread of #Candida auris in China after COVID-19 - Journal of Infection www.journalofinfection.com/article/S016...
Incredible how fungi can evolve! In our latest manuscript, we describe an intriguing case of hyper-MDR in C. glabrata and highlight the therapeutic potential of collateral sensitivity and nitroxoline for such therapeutic dead ends! www.biorxiv.org/content/10.1...
Survival of the unfittest: clinical emergence of hyper-multidrug-resistant Nakaseomyces glabratus with rare nonfunctional Erg3 and Erg11 and severely impaired fitness.
Background : Nakaseomyces glabratus (Candida gabrata) poses a significant clinical challenge due to common drug resistance. We report a case of a complicated urinary tract infection (UTI) progressing ...
www.biorxiv.org
February 6, 2025 at 3:39 PM
Incredible how fungi can evolve! In our latest manuscript, we describe an intriguing case of hyper-MDR in C. glabrata and highlight the therapeutic potential of collateral sensitivity and nitroxoline for such therapeutic dead ends! www.biorxiv.org/content/10.1...
Reposted by Hans Carolus
Logging into microsoft teams
January 16, 2025 at 8:49 AM
Logging into microsoft teams
Reposted by Hans Carolus
Extremely validating. I’ll never complain about C. albicans again after working with CRISPR in C. auris
January 10, 2025 at 6:14 PM
Extremely validating. I’ll never complain about C. albicans again after working with CRISPR in C. auris
When I started my PhD 6 years ago, this sticker on my office door got me excited. Sure! let's "CRISPR Candida auris"! Today I am excited to show that that's not as easy as it sounds! 😉 Read our latest preprint on the challenges with editing C. auris: www.biorxiv.org/content/10.1...
January 10, 2025 at 4:10 PM
When I started my PhD 6 years ago, this sticker on my office door got me excited. Sure! let's "CRISPR Candida auris"! Today I am excited to show that that's not as easy as it sounds! 😉 Read our latest preprint on the challenges with editing C. auris: www.biorxiv.org/content/10.1...
Thrilled to announce I was awarded an EMBO postdoctoral fellowship to join the lab of @christianlandry.bsky.social @ @universitelaval.bsky.social next April! Exciting science across the pond ahead! #EMBOFellows
December 17, 2024 at 9:48 AM
Thrilled to announce I was awarded an EMBO postdoctoral fellowship to join the lab of @christianlandry.bsky.social @ @universitelaval.bsky.social next April! Exciting science across the pond ahead! #EMBOFellows
Reposted by Hans Carolus
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi
-in NPJ antimicrobials and resistance from @hanscarolus.bsky.social
with Patrick van Dijck lab
www.nature.com/articles/s44...
-in NPJ antimicrobials and resistance from @hanscarolus.bsky.social
with Patrick van Dijck lab
www.nature.com/articles/s44...
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi
www.nature.com
December 15, 2024 at 10:48 AM
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi
-in NPJ antimicrobials and resistance from @hanscarolus.bsky.social
with Patrick van Dijck lab
www.nature.com/articles/s44...
-in NPJ antimicrobials and resistance from @hanscarolus.bsky.social
with Patrick van Dijck lab
www.nature.com/articles/s44...
My first paper as senior author is out! Lots of new ideas for experimental evolution studies with fungi, and again, a nice collaboration with Giorgio Boccarella and Piet van den Berg.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi
www.nature.com
December 12, 2024 at 12:56 PM
My first paper as senior author is out! Lots of new ideas for experimental evolution studies with fungi, and again, a nice collaboration with Giorgio Boccarella and Piet van den Berg.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Reposted by Hans Carolus
#paper #candida #AMR
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
@naturemicrobiol.bsky.social @tonigabaldon.bsky.social nice collab with @hanscarolus.bsky.social
www.nature.com/articles/s41...
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
@naturemicrobiol.bsky.social @tonigabaldon.bsky.social nice collab with @hanscarolus.bsky.social
www.nature.com/articles/s41...
December 4, 2024 at 10:09 AM
#paper #candida #AMR
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
@naturemicrobiol.bsky.social @tonigabaldon.bsky.social nice collab with @hanscarolus.bsky.social
www.nature.com/articles/s41...
Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris
@naturemicrobiol.bsky.social @tonigabaldon.bsky.social nice collab with @hanscarolus.bsky.social
www.nature.com/articles/s41...
Reposted by Hans Carolus
In case you missed these two recent Nature Microbiology studies on Candida auris AMR by @hanscarolus.bsky.social and colleagues:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris - Nature Microbiology
Collateral-sensitivity-based drug cycling effectively prevents and impedes the evolution of antifungal drug resistance in Candida auris.
www.nature.com
December 4, 2024 at 6:04 PM
In case you missed these two recent Nature Microbiology studies on Candida auris AMR by @hanscarolus.bsky.social and colleagues:
www.nature.com/articles/s41...
www.nature.com/articles/s41...