Hannah Stabb
@hannah-stabb.bsky.social
PhD student in Botond Roska’s lab at IOB
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Couldn’t be prouder of my big sister! Her paper on proPE — a Prime Editing system with prolonged editing window — just came out in Nature Catalysis! By using two RNAs instead of one, proPE expands prime editing to previously unreachable, disease-linked SNPs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ProPE expands the prime editing window and enhances gene editing efficiency where prime editing is inefficient - Nature Catalysis
Prime editing is a CRISPR methodology whose efficiency declines with distance from the target sequence. Here the authors demonstrate prime editing with prolonged editing window, proPE, which extends the editing distance, enabling the use of prime editing for therapeutic interventions.
www.nature.com
October 10, 2025 at 9:18 PM
Couldn’t be prouder of my big sister! Her paper on proPE — a Prime Editing system with prolonged editing window — just came out in Nature Catalysis! By using two RNAs instead of one, proPE expands prime editing to previously unreachable, disease-linked SNPs.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Hannah Stabb
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
nature.com
February 18, 2025 at 10:07 AM
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9
Reposted by Hannah Stabb
Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.
September 15, 2025 at 9:19 AM
Single-cell electroporation is performed via patch pipette and under 2-photon visual guidance in vivo. A short voltage pulse train is applied through the pipette to deliver RNA molecules into a targeted cell. The video below shows this process in cortical neurons expressing GCaMP6s.
Another bold colour added to the genome editing palette. Can’t wait to see how bridge recombinases reshape what’s possible in genome engineering.
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases
Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study,...
www.science.org
September 29, 2025 at 7:12 AM
Another bold colour added to the genome editing palette. Can’t wait to see how bridge recombinases reshape what’s possible in genome engineering.
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Megabase-scale human genome rearrangement with programmable bridge recombinases | Science www.science.org/doi/10.1126/...
Congratulations to Georg and Alex for the beautiful work!
Gene editing of single, targeted neurons in vivo is now feasible. We are proud to present our preprint for highly efficient single-cell electroporation using RNA. With @alex-fratzl.bsky.social, @munzlab.bsky.social, Botond Roska @iobswiss.bsky.social
#neuroskyence
www.biorxiv.org/content/10.1...
#neuroskyence
www.biorxiv.org/content/10.1...
In vivo single-cell gene editing using RNA electroporation reveals sequential adaptation of cortical neurons to excitatory-inhibitory imbalance
The balance between excitatory and inhibitory neurotransmission is fundamental for normal brain function, yet the adaptation of individual neurons to disrupted excitatory-inhibitory balance is not wel...
www.biorxiv.org
September 23, 2025 at 2:43 PM
Congratulations to Georg and Alex for the beautiful work!
Reposted by Hannah Stabb
How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Joint visual-vestibular computation of head direction and reflexive eye movement
Several cognitive maps have been identified, but what sensory signals drive them and how these are combined are not well understood. One such map, the head-direction representation, is believed to be ...
www.biorxiv.org
February 12, 2025 at 6:42 AM
How do different sensory signals combine in the computation of cognitive maps? I’m thrilled to share our new preprint, in which we investigate this question in the context of the head-direction system:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...