Gyunghee Jo
@gyungheejo.bsky.social
Postdoc at Scripps Research - Ward lab
Reposted by Gyunghee Jo
I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses
Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with...
www.medrxiv.org
September 26, 2025 at 12:49 PM
I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Just published in Nature Communications!🎆
We show how a recurring motif in antibody CDR H3 mimics sialic acid at the influenza neuraminidase active site, allowing broad binding and making it a promising vaccine target!💡🦠
doi.org/10.1038/s414...
We show how a recurring motif in antibody CDR H3 mimics sialic acid at the influenza neuraminidase active site, allowing broad binding and making it a promising vaccine target!💡🦠
doi.org/10.1038/s414...
Structural basis of broad protection against influenza virus by human antibodies targeting the neuraminidase active site via a recurring motif in CDR H3 - Nature Communications
Recurrent features in human antibodies targeting the influenza neuraminidase active site reveal a convergent strategy of receptor mimicry, providing structural insights that could guide the design of ...
doi.org
August 2, 2025 at 6:03 PM
Just published in Nature Communications!🎆
We show how a recurring motif in antibody CDR H3 mimics sialic acid at the influenza neuraminidase active site, allowing broad binding and making it a promising vaccine target!💡🦠
doi.org/10.1038/s414...
We show how a recurring motif in antibody CDR H3 mimics sialic acid at the influenza neuraminidase active site, allowing broad binding and making it a promising vaccine target!💡🦠
doi.org/10.1038/s414...
Reposted by Gyunghee Jo
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed mill
www.biorxiv.org
December 3, 2024 at 7:15 PM
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies https://www.biorxiv.org/content/10.1101/2024.11.27.625426v1
Reposted by Gyunghee Jo
Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3 https://www.biorxiv.org/content/10.1101/2024.11.26.625467v1
Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3 https://www.biorxiv.org/content/10.1101/2024.11.26.625467v1
Influenza viruses evolve rapidly, driving seasonal epidemics and posing global pandemic threats. Whi
www.biorxiv.org
December 2, 2024 at 3:15 AM
Structural basis of broad protection against influenza virus by a human antibody targeting the neuraminidase active site via a recurring motif in CDR H3 https://www.biorxiv.org/content/10.1101/2024.11.26.625467v1