Guilherme Sena
@guilhermesena1.bsky.social
Brazil→France→USA→Portugal→UK. Interested in creating computational tools that use DNA sequencing to understand the biology of every organism.
Reposted by Guilherme Sena
Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes"
📄 www.nature.com/articles/s41...
📻 www.sciencefriday.com/segments/65-...
📄 www.nature.com/articles/s41...
📻 www.sciencefriday.com/segments/65-...
65 Genomes Expand Our Picture Of Human Genetics
Researchers closely examined the genomes of 65 individuals to paint a more complex, and more complete, picture of human genetic diversity.
www.sciencefriday.com
August 1, 2025 at 8:49 PM
Complete genomes alert! @glennislogsdon.bsky.social, @christinebeck.bsky.social, and I were on @scifri.bsky.social today talking about "Complex genetic variation in nearly complete human genomes"
📄 www.nature.com/articles/s41...
📻 www.sciencefriday.com/segments/65-...
📄 www.nature.com/articles/s41...
📻 www.sciencefriday.com/segments/65-...
Reposted by Guilherme Sena
Look at this gorgeous chonk of a baby. Look at his lil face. We are treating his life-threatening ultra-rare genetic condition with super cool science. With a gene editing tool that we stole from bacteria! Just in case you also needed a reminder that humanity can still do some pretty awesome stuff.
A promising genetic treatment tailor-made for a baby born with a rare disorder
For the first time, doctors have created a customized treatment using the revolutionary gene-editing technique known as CRISPR to treat a baby with a rare, life-threatening genetic disorder.
www.npr.org
May 16, 2025 at 3:34 AM
Look at this gorgeous chonk of a baby. Look at his lil face. We are treating his life-threatening ultra-rare genetic condition with super cool science. With a gene editing tool that we stole from bacteria! Just in case you also needed a reminder that humanity can still do some pretty awesome stuff.
Reposted by Guilherme Sena
Our primate T2T paper came out in Nature yesterday! It was a huge effort and I'm so grateful that I got the opportunity to work with this amazing group of scientists over the first two years of my PhD!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Complete sequencing of ape genomes - Nature
Complete sequences of chromosomes telomere-to-telomere from chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan and siamang provide a comprehensive and valuable resource for future evol...
www.nature.com
April 10, 2025 at 9:59 PM
Our primate T2T paper came out in Nature yesterday! It was a huge effort and I'm so grateful that I got the opportunity to work with this amazing group of scientists over the first two years of my PhD!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Guilherme Sena
Great to see that sawfish, our new HiFi SV caller, is accepted for publication in Bioinformatics! Sawfish emphasizes local haplotype modeling to improve SV representation and genotyping in both single and joint-sample analysis. Advance-access article now available: (1/n)
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
Sawfish: Improving long-read structural variant discovery and genotyping with local haplotype modeling
AbstractMotivation. Structural variants (SVs) play an important role in evolutionary and functional genomics but are challenging to characterize. High-accu
doi.org
April 10, 2025 at 3:41 PM
Great to see that sawfish, our new HiFi SV caller, is accepted for publication in Bioinformatics! Sawfish emphasizes local haplotype modeling to improve SV representation and genotyping in both single and joint-sample analysis. Advance-access article now available: (1/n)
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
Reposted by Guilherme Sena
New @naturecomms.bsky.social paper reveals the hidden world of human pseudogenes, thanks to #PacBio HiFi sequencing. Researchers overcome short-read limitations to provide a more complete and accurate view of genetic variation and improve disease-linked variant identification. bit.ly/41zlRmJ
March 17, 2025 at 3:28 PM
New @naturecomms.bsky.social paper reveals the hidden world of human pseudogenes, thanks to #PacBio HiFi sequencing. Researchers overcome short-read limitations to provide a more complete and accurate view of genetic variation and improve disease-linked variant identification. bit.ly/41zlRmJ
That's adorable!
March 1, 2025 at 11:36 AM
That's adorable!
Reposted by Guilherme Sena
Epigenetics controls gene expression, but how do we see these modifications? Enter #PacBio Fiber-Seq—a groundbreaking method that maps DNA methylation & chromatin structure at single-molecule resolution. bit.ly/4gfQbrW
#AGBTGM #AGBT25
#AGBTGM #AGBT25
Sequencing 101: Epigenetics - PacBio
Epigenetics can impact everything from development to disease. See how PacBio HiFi sequencing technology is changing the game.
bit.ly
February 23, 2025 at 5:01 PM
Epigenetics controls gene expression, but how do we see these modifications? Enter #PacBio Fiber-Seq—a groundbreaking method that maps DNA methylation & chromatin structure at single-molecule resolution. bit.ly/4gfQbrW
#AGBTGM #AGBT25
#AGBTGM #AGBT25
I wrote about a fun combinatorial problem I came across that is very useful in bioinformatics: Add marbles to k boxes, one at a time, independently, uniformly at random. How many marbles are needed for the probability that every box has at least r marbles to be at least p?
tinyurl.com/gs-stirling
tinyurl.com/gs-stirling
Stirling numbers and a useful combinatorics problem for bioinformatics
It never ceases to amaze me that sometimes in combinatorics the difference between an elementary school problem and a lifelong career in math is one additional sentence in a problem statement.
guilhermesena1.github.io
February 12, 2025 at 11:17 PM
I wrote about a fun combinatorial problem I came across that is very useful in bioinformatics: Add marbles to k boxes, one at a time, independently, uniformly at random. How many marbles are needed for the probability that every box has at least r marbles to be at least p?
tinyurl.com/gs-stirling
tinyurl.com/gs-stirling
My first animation with the manim python package! Inspired by the following question: What is the probability that a triangle whose vertices are uniformly sampled from the surface of a circle contains it center? Do you know the answer intuitively?
guilhermesena1.github.io/posts/manima...
guilhermesena1.github.io/posts/manima...
Manim, and variations of a geometry problem
IMC 2024 problem 5
guilhermesena1.github.io
December 26, 2024 at 8:21 PM
My first animation with the manim python package! Inspired by the following question: What is the probability that a triangle whose vertices are uniformly sampled from the surface of a circle contains it center? Do you know the answer intuitively?
guilhermesena1.github.io/posts/manima...
guilhermesena1.github.io/posts/manima...
Reposted by Guilherme Sena
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
December 17, 2024 at 1:15 AM
Bioart, courtesy of the NIH. All images are in the public domain and available for download as high-quality SVGs.
bioart.niaid.nih.gov
bioart.niaid.nih.gov
I wrote a post in my blog after 2.5 years. It's about a string problem I passed to my students long ago. It's also about DNA palindromes and a cool application of the KMP algorithm for prefix-suffix matching. Avoid this post if you suffer from aibohphobia.
guilhermesena1.github.io/posts/palind...
guilhermesena1.github.io/posts/palind...
Palindromes palindromes palindromes!
This post explores the solution of a problem I proposed to my undergrad students when I was a TA in a computational molecular biology course. It involves palindromes so readers who suffer from aibohph...
guilhermesena1.github.io
December 3, 2024 at 11:44 PM
I wrote a post in my blog after 2.5 years. It's about a string problem I passed to my students long ago. It's also about DNA palindromes and a cool application of the KMP algorithm for prefix-suffix matching. Avoid this post if you suffer from aibohphobia.
guilhermesena1.github.io/posts/palind...
guilhermesena1.github.io/posts/palind...