@guilhasneves.bsky.social
Reposted
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
October 4, 2025 at 2:16 AM
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
Reposted
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome
Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...
www.biorxiv.org
October 6, 2025 at 9:50 AM
I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
October 4, 2025 at 2:16 AM
Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome https://www.biorxiv.org/content/10.1101/2025.10.03.680281v1
Imagine trying to find a tiny house in a huge city, without the help of Google maps. This is the challenge scientists face when studying cells and tissues using Volume Correlative Light and Electron Microscopy (vCLEM), a method that combines different imaging techniques to get a complete picture.
June 30, 2025 at 9:24 PM
Imagine trying to find a tiny house in a huge city, without the help of Google maps. This is the challenge scientists face when studying cells and tissues using Volume Correlative Light and Electron Microscopy (vCLEM), a method that combines different imaging techniques to get a complete picture.