Berkley Gryder
gryderart.bsky.social
Berkley Gryder
@gryderart.bsky.social
Childhood Cancer Epigenetics and Drug Discovery
Assistant Prof. at Case Western Reserve University
gryderlab.com
Proud of my collaborator @KidCancerLab for discovering how wound healing programs promote lung metastasis!
"Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...
November 21, 2024 at 5:11 PM
Our story in PNAS today!
(1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription
(2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter!
www.pnas.org/doi/10.1073/pnas.2406239121
November 19, 2024 at 5:44 PM