Berkley Gryder
@gryderart.bsky.social
Childhood Cancer Epigenetics and Drug Discovery
Assistant Prof. at Case Western Reserve University
gryderlab.com
Assistant Prof. at Case Western Reserve University
gryderlab.com
Reposted by Berkley Gryder
New paper in Nature Comms with Isaac Brownell NIAMS, identifying #repurposing treatment options for the rare Merkel Cell Carcinoma (MCC). We found Aurora kinase criticality in genetic & chemogenomic screens - wonderful collaboration @gryderart.bsky.social #NCATS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 13, 2025 at 5:25 PM
New paper in Nature Comms with Isaac Brownell NIAMS, identifying #repurposing treatment options for the rare Merkel Cell Carcinoma (MCC). We found Aurora kinase criticality in genetic & chemogenomic screens - wonderful collaboration @gryderart.bsky.social #NCATS
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Proud of my collaborator @KidCancerLab for discovering how wound healing programs promote lung metastasis!
"Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...
"Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...
November 21, 2024 at 5:11 PM
Proud of my collaborator @KidCancerLab for discovering how wound healing programs promote lung metastasis!
"Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...
"Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cells" aacrjournals.org/clincancerre...
Our story in PNAS today!
(1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription
(2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter!
www.pnas.org/doi/10.1073/pnas.2406239121
(1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription
(2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter!
www.pnas.org/doi/10.1073/pnas.2406239121
November 19, 2024 at 5:44 PM
Our story in PNAS today!
(1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription
(2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter!
www.pnas.org/doi/10.1073/pnas.2406239121
(1) anti-AR molecules with new mechanism: induction of chromatin binding YET a disruption of transcription
(2) why only ~150 genes respond to AR ligands, despite the 6,000+ AR binding sites: they need 3D clustering to matter!
www.pnas.org/doi/10.1073/pnas.2406239121