Kira Gritsman
@gritsmanlab.bsky.social
Physician-scientist studying leukemic stem cells and hematopoiesis #signaling #PTMs #non-genetic resistance mechanisms #microenvironment
Associate Professor at Albert Einstein College of Medicine
Associate Professor at Albert Einstein College of Medicine
Happy to contribute to this exciting project just published in @nature.com led by the amazing Shoichiro Takeishi in a fantastic collaboration with @steidluli.bsky.social - check out this thread 🩸 🧬
Please check out this thread on our latest paper in
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)
Haematopoietic stem cell number is not solely defined by niche availability
Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.
rdcu.be
August 28, 2025 at 2:52 AM
Happy to contribute to this exciting project just published in @nature.com led by the amazing Shoichiro Takeishi in a fantastic collaboration with @steidluli.bsky.social - check out this thread 🩸 🧬
Reposted by Kira Gritsman
Glimmer of hope: the Senate Labor, Health and Human Services Subcommittee just voted, 26 to 3, to reject the administration’s proposed cuts & instead recommend a $400 million increase to the NIH budget. The House LHHS Subcommittee convenes in September
www.appropriations.senate.gov/news/minorit...
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www.appropriations.senate.gov/news/minorit...
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Senate Appropriations Committee Approves Defense and Labor, Health and Human Services, and Education Bills | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
August 1, 2025 at 8:54 PM
Glimmer of hope: the Senate Labor, Health and Human Services Subcommittee just voted, 26 to 3, to reject the administration’s proposed cuts & instead recommend a $400 million increase to the NIH budget. The House LHHS Subcommittee convenes in September
www.appropriations.senate.gov/news/minorit...
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www.appropriations.senate.gov/news/minorit...
🧪
Reposted by Kira Gritsman
So impressed at the increased support the American Society of Hematology is planning for trainees and early-career investigators!! At some point, someone invested in us. Now it’s our turn. #Fight4Hematology and secure the future of hematology research. Donate! #hemesky www.hematology.org/foundation
ASH Foundation
The ASH Foundation is dedicated to moving hematology forward through charitable support for ASH programs – helping hematologists conquer blood diseases worldwide.
www.hematology.org
July 31, 2025 at 2:35 PM
So impressed at the increased support the American Society of Hematology is planning for trainees and early-career investigators!! At some point, someone invested in us. Now it’s our turn. #Fight4Hematology and secure the future of hematology research. Donate! #hemesky www.hematology.org/foundation
Reposted by Kira Gritsman
Interested in a mentor to guide your career in malignant hematology? Apply for the ASH’s new Mentorship Program, and grow your network! Deadline: Sept 26. Apply today! 🔗 https://bit.ly/3IPWjMA
Interested in becoming a mentor? Sign up today: https://bit.ly/3U5tm1t
#HemeSky
Interested in becoming a mentor? Sign up today: https://bit.ly/3U5tm1t
#HemeSky
July 31, 2025 at 6:30 PM
Interested in a mentor to guide your career in malignant hematology? Apply for the ASH’s new Mentorship Program, and grow your network! Deadline: Sept 26. Apply today! 🔗 https://bit.ly/3IPWjMA
Interested in becoming a mentor? Sign up today: https://bit.ly/3U5tm1t
#HemeSky
Interested in becoming a mentor? Sign up today: https://bit.ly/3U5tm1t
#HemeSky
Reposted by Kira Gritsman
The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social
July 21, 2025 at 7:27 PM
The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social
Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team
So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @gritsmanlab.bsky.social
Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells https://www.biorxiv.org/content/10.1101/2025.07.11.663968v1
July 16, 2025 at 1:45 AM
Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team
So excited that our collaboration with the Shechter lab on a new targetable PTM -glutamylation- on NPM1c in AML is now on BioRxiv! Team effort led by @alexkschurer.bsky.social and @humaira2204.bsky.social! 🧪🩸
April 10, 2025 at 8:48 PM
So excited that our collaboration with the Shechter lab on a new targetable PTM -glutamylation- on NPM1c in AML is now on BioRxiv! Team effort led by @alexkschurer.bsky.social and @humaira2204.bsky.social! 🧪🩸
Reposted by Kira Gritsman
#NIHfunding cuts have resulted in stalled research. In response, ASH is expanding its Bridge Grant Program with $150K in awards to support critical research by members. Donate to support #hematology researchers and help ensure innovative research continues: https://bit.ly/41LFwjD
#HemeSky #MedSky
#HemeSky #MedSky
March 21, 2025 at 3:00 PM
#NIHfunding cuts have resulted in stalled research. In response, ASH is expanding its Bridge Grant Program with $150K in awards to support critical research by members. Donate to support #hematology researchers and help ensure innovative research continues: https://bit.ly/41LFwjD
#HemeSky #MedSky
#HemeSky #MedSky
Reposted by Kira Gritsman
If you have applied to an R01 or equivalent, please check out the new eligibility. #hematology #medsky #phdsky #scisky #science
In response to changes in the #NIHfunding, ASH is expanding access and eligibility for the 2025 Bridge Grant Program for #researchers.
Ready to enhance your career? Apply today: https://bit.ly/3F55fvz
#ASHAwards #Hematology #Grants #Hemesky #Fight4Hematolog
Ready to enhance your career? Apply today: https://bit.ly/3F55fvz
#ASHAwards #Hematology #Grants #Hemesky #Fight4Hematolog
March 11, 2025 at 2:44 AM
If you have applied to an R01 or equivalent, please check out the new eligibility. #hematology #medsky #phdsky #scisky #science
Reposted by Kira Gritsman
I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all.
time.com/7216299/nih-...
time.com/7216299/nih-...
Experts Call NIH Budget Cuts an 'Apocalypse' for Science
The reductions target indirect costs that cover administrative and equipment costs.
time.com
February 15, 2025 at 9:28 PM
I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all.
time.com/7216299/nih-...
time.com/7216299/nih-...
Reposted by Kira Gritsman
📢 Support federal research funding!
As the new Administration acts & Congress finalizes FY25 funding, lawmakers need to hear from you. Share your stories of how funding & policies impact #hematology patients & research.
Take action! bit.ly/4b2bj43
#Fight4Hematology #HemeSky #BloodSky
As the new Administration acts & Congress finalizes FY25 funding, lawmakers need to hear from you. Share your stories of how funding & policies impact #hematology patients & research.
Take action! bit.ly/4b2bj43
#Fight4Hematology #HemeSky #BloodSky
February 14, 2025 at 4:47 PM
📢 Support federal research funding!
As the new Administration acts & Congress finalizes FY25 funding, lawmakers need to hear from you. Share your stories of how funding & policies impact #hematology patients & research.
Take action! bit.ly/4b2bj43
#Fight4Hematology #HemeSky #BloodSky
As the new Administration acts & Congress finalizes FY25 funding, lawmakers need to hear from you. Share your stories of how funding & policies impact #hematology patients & research.
Take action! bit.ly/4b2bj43
#Fight4Hematology #HemeSky #BloodSky
Reposted by Kira Gritsman
Calling all aspiring hematologists in med school — don’t leave research funding on the table! 💰
✨ HIP Medical Student Award
✨ HONORS Award
✨ Physician-Scientist Award
Learn more: https://bit.ly/4hexNk7. Your application is due on Feb. 14!
#ASHTrainee #HemeSky #BloodSky #Hematology
✨ HIP Medical Student Award
✨ HONORS Award
✨ Physician-Scientist Award
Learn more: https://bit.ly/4hexNk7. Your application is due on Feb. 14!
#ASHTrainee #HemeSky #BloodSky #Hematology
January 28, 2025 at 1:00 PM
Calling all aspiring hematologists in med school — don’t leave research funding on the table! 💰
✨ HIP Medical Student Award
✨ HONORS Award
✨ Physician-Scientist Award
Learn more: https://bit.ly/4hexNk7. Your application is due on Feb. 14!
#ASHTrainee #HemeSky #BloodSky #Hematology
✨ HIP Medical Student Award
✨ HONORS Award
✨ Physician-Scientist Award
Learn more: https://bit.ly/4hexNk7. Your application is due on Feb. 14!
#ASHTrainee #HemeSky #BloodSky #Hematology
Congratulations to all the new ASH Scholars!
#ASHKudos to the 2025 ASH Scholar Award recipients!
This award supports early career investigators as they transition from training programs to careers as independent investigators.
Learn more: https://bit.ly/4haW3Ue
#ASHAwards #Hematology #HemeSky #BloodSky @b-avalos-md.bsky.social
This award supports early career investigators as they transition from training programs to careers as independent investigators.
Learn more: https://bit.ly/4haW3Ue
#ASHAwards #Hematology #HemeSky #BloodSky @b-avalos-md.bsky.social
January 22, 2025 at 12:03 AM
Congratulations to all the new ASH Scholars!
Reposted by Kira Gritsman
Delighted to share our #hematology review article on mutant calreticulin in #MPN
Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social
link.springer.com/article/10.1...
Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social
link.springer.com/article/10.1...
Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications - Current Hematologic Malignancy Reports
Purpose of Review More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continu...
link.springer.com
January 10, 2025 at 3:29 PM
Delighted to share our #hematology review article on mutant calreticulin in #MPN
Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social
link.springer.com/article/10.1...
Congrats to co-authors Drs. Mifra Faiz, Merle Riedemann & Jonas Jutzi. We hope it’s a useful resource, link below! @stanforddeptmed.bsky.social
link.springer.com/article/10.1...
Reposted by Kira Gritsman
Inflammation plays a key role in RUNX1-FPD pathogenesis. Dr. Anupriya Agarwal & her team at @ohsunews.bsky.social found targeting CD74 signaling, mTOR & JAK1/2 pathways could prevent disease progression. Incredible work by an RRP-EdwardPEvansFdn FIRE grant recipient! www.science.org/doi/10.1126/...
Targeting the CD74 signaling axis suppresses inflammation and rescues defective hematopoiesis in RUNX1-familial platelet disorder
CD74 signaling drives inflammation and differentiation defects in hematopoietic stem and progenitor cells in RUNX1-familial platelet disorder.
www.science.org
January 9, 2025 at 9:33 PM
Inflammation plays a key role in RUNX1-FPD pathogenesis. Dr. Anupriya Agarwal & her team at @ohsunews.bsky.social found targeting CD74 signaling, mTOR & JAK1/2 pathways could prevent disease progression. Incredible work by an RRP-EdwardPEvansFdn FIRE grant recipient! www.science.org/doi/10.1126/...
Reposted by Kira Gritsman
Stanford #Hematology is recruiting! #ASH24 attendees, pls reach out to me if interested! 👇🏽@stanforddeptmed.bsky.social
Stanford Hematology is recruiting a physician-scientist in heme malignancies, details below, pls share, pls reach out with Qs, I’m excited to grow our amazing Division! @stanforddeptmed.bsky.social
December 9, 2024 at 4:51 PM
Stanford #Hematology is recruiting! #ASH24 attendees, pls reach out to me if interested! 👇🏽@stanforddeptmed.bsky.social
Reposted by Kira Gritsman
Excited for this workshop this afternoon and grateful to the organizers Christina Glytsou, Panos Ntziachristos, & Dan Starczynowski for the opportunity to speak in the session alongside @gritsmanlab.bsky.social & Marek Mraz! #ASH24 #hemesky @ash-hematology.bsky.social
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
December 6, 2024 at 3:36 PM
Excited for this workshop this afternoon and grateful to the organizers Christina Glytsou, Panos Ntziachristos, & Dan Starczynowski for the opportunity to speak in the session alongside @gritsmanlab.bsky.social & Marek Mraz! #ASH24 #hemesky @ash-hematology.bsky.social
ash.confex.com/ash/2024/web...
ash.confex.com/ash/2024/web...
Reposted by Kira Gritsman
So sad I am missing #ASH2024 But if you’re there early enough be sure to check out the wonderful @gritsmanlab.bsky.social present exciting updates from my work at the therapy resistance workshop on Friday! 2-5pm in SDCC room 33!
December 6, 2024 at 3:52 AM
So sad I am missing #ASH2024 But if you’re there early enough be sure to check out the wonderful @gritsmanlab.bsky.social present exciting updates from my work at the therapy resistance workshop on Friday! 2-5pm in SDCC room 33!
Check out our new review by the amazing @alexkschurer.bsky.social and @thehematopoet.bsky.social on chromatin modifiers in AML! Just in time for the first menin inhibitor FDA approval! 🧪🩸
Overwhelmed by all of the exciting new research on chromatin modifiers in AML? Find it hard to keep track of all the new menin inhibitors? Well good news, we’ve just published the perfect review for you in SCTM!
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...
@alexkschurer.bsky.social
@gritsmanlab.bsky.social
academic.oup.com/stcltm/advan...
Targeting chromatin modifying complexes in acute myeloid leukemia
Abstract. Acute myeloid leukemia (AML) is a devastating hematologic malignancy with high rates of relapse, which can, in part, be attributed to the dysregu
academic.oup.com
December 4, 2024 at 4:33 AM
Check out our new review by the amazing @alexkschurer.bsky.social and @thehematopoet.bsky.social on chromatin modifiers in AML! Just in time for the first menin inhibitor FDA approval! 🧪🩸
Reposted by Kira Gritsman
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Kira Gritsman
Big day for our field! 🎉
November 15, 2024 at 9:25 PM
Big day for our field! 🎉
Reposted by Kira Gritsman
First manuscript from Linde Miles Lab at CCHMC looking at clonal evolution in NPM1-mut AML at single cell resolution. Check out the pre-print here: www.biorxiv.org/content/10.1...
Genotype-immunophenotype relationships in NPM1-mutant AML clonal evolution uncovered by single cell multiomic analysis
Acute myeloid leukemia (AML) is a multi-clonal disease, existing as a milieu of clones with unique but related genotypes as initiating clones acquire subsequent mutations. However, bulk sequencing can...
www.biorxiv.org
November 17, 2024 at 9:26 PM
First manuscript from Linde Miles Lab at CCHMC looking at clonal evolution in NPM1-mut AML at single cell resolution. Check out the pre-print here: www.biorxiv.org/content/10.1...