Grant Pellowe
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grantpellowe.bsky.social
Grant Pellowe
@grantpellowe.bsky.social
320 followers 980 following 3 posts
Research fellow at Aston Institute of Membrane Excellence. Previously folding proteins at The Crick and membrane proteins at King's College London.
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Reposted by Grant Pellowe
davidbalchin.bsky.social
Our story on GroEL/ES action during cotranslational folding is now published @natcomms.nature.com. Led by former-student Alzbeta Roeselova, and in collaboration with Rado Enchev's lab @crick.ac.uk.
www.nature.com/articles/s41...
GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome - Nature Communications
The GroEL/ES chaperonin can act during protein synthesis to promote folding. Here, Roeselová et al. show how GroEL captures, remodels and sequesters nascent proteins in its central chamber, while they...
www.nature.com
November 14, 2025 at 1:49 PM
Reposted by Grant Pellowe
pstansfeld.bsky.social
Biochemical Society's Membrane Protein Conference
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel

- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...

#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social
October 24, 2025 at 8:07 AM
Reposted by Grant Pellowe
natsmb.nature.com
New online: The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking
Nature Structural & Molecular Biology, Published online: 19 September 2025; doi:10.1038/s41594-025-01676-5By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.
go.nature.com
September 19, 2025 at 10:12 AM
grantpellowe.bsky.social
Re-advertising! Closes September 1st.

💧 Interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social

tinyurl.com/5dc23mu3

Reach out for details!
Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com
PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com
tinyurl.com
May 28, 2025 at 12:02 PM
grantpellowe.bsky.social
1 week to go - get your applications in!
March 31, 2025 at 10:04 AM
Reposted by Grant Pellowe
biorxiv-biochem.bsky.social
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking https://www.biorxiv.org/content/10.1101/2024.09.19.613857v1
Proteins with multiple domains are intrinsically prone to misfold, yet fold efficiently during their
www.biorxiv.org
September 20, 2024 at 3:46 AM
grantpellowe.bsky.social
💧 Are you interested in understanding how Aquaporins fold into membranes as they're being synthesised? 💧

If so, come and do your PhD with me, @kitchenphil.bsky.social and @roslynbill.bsky.social at @astonaime.bsky.social!

www.findaphd.com/phds/project...

Reach out for further details!
Delineating stages of Aquaporin biogenesis at Aston University on FindAPhD.com
PhD Project - Delineating stages of Aquaporin biogenesis at Aston University, listed on FindAPhD.com
www.findaphd.com
February 24, 2025 at 6:52 PM