Grace Choung, MD 박영이
gracechoung.bsky.social
Grace Choung, MD 박영이
@gracechoung.bsky.social
Renal pathologist @CedarsSinai
#renalpath #kidneydisease
opinions are my own
Fibronectin glomerulopathy
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited

(1/2) more below
#renalpath #pathsky #nephsky
August 6, 2025 at 3:18 AM
Anti-tubular basement membrane (TBM) disease
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia

Reference: ajkd.org/article/s027...

#renalpath #pathsky #nephsky
July 3, 2025 at 4:00 AM
A membranous pattern is occasionally present in Fibrillary GN
Notice randomly arranged fibrils in the subepithelial regions. DNAJB9-positivity is seen in a similar distribution by IHC. Can be mistaken for membranous nephropathy: doi.org/10.1016/j.ekir…#renalpatht#pathskyk#nephskyky
June 24, 2025 at 11:43 PM
TMA involving blood vessels
🔹Onion-skin type intimal fibrosis
🔹Mucointimal edema
🔹Endothelial cell enlargement
🔹Fragmented RBCs
🔹Fibrin thrombi & fibrin in intima
DD:
*Malignant HTN
*Scleroderma
*Other causes of TMA (e.g., aHUS, anti-phosphlipid, etc)
#renalpath #pathsky #nephsky #medsky
April 26, 2025 at 5:46 PM
Immunotactoid GN
•Often associated with lymphoproliferative disorder
•IF: Often clonal IgG & K/L-restricted
•EM: Hollow microtubules arranged in “parallel stacked arrays” or bundles
•Mean diameter 40 nm (20-60)
•Cryogloblins should be excluded
#renalpath #pathsky #nephsky #medsky
April 26, 2025 at 5:45 PM
Patient with sarcoidosis p/w renal dysfunction.
LM: Discrete well-formed non-necrotizing granulomas
Granulomatous TIN differential:
•Sarcoidosis
•Infections (TB, fungus)
•Reaction to ruptured tubules in AIN
•Foreign body reaction
•Vasculitis (ANCA)
#renalpath #pathsky #nephsky #medsky
April 16, 2025 at 4:37 AM
Lysozyme nephropathy
•Rare cause of AKI in monocytic leukemias
•Proximal tubules have hypereosinophilic granular cytoplasm, which are PAS +/- & silver➖
•IHC stain: lysozyme strongly➕in cytoplasm
•EM:⬆️# of lysosomes with electron dense stuff
#renalpath #nephsky, #pathsky #medsky
April 16, 2025 at 4:35 AM
MPN-related glomerulopathy (in this case CMML)
Megakaryocytes in glomerular capillaries & features of glomerular TMA
Other path fx: Mesangial sclerosis & hypercellularity, & FSGS
Clinically: proteinuria & renal dysfxn pubmed.ncbi.nlm.nih.gov/21654720/
#renalpath #nephsky #pathsky #medsky
April 16, 2025 at 4:31 AM
Pt with CMML & subnephrotic proteinuria & renal dysfunction
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
April 16, 2025 at 4:28 AM
Amyloidosis in kidney medulla only.
Congo red-positive.
IF is (-) for kappa & lambda.
Mass spectrometry --> Apolipoprotein A-IV
Very rare type of amyloidosis, typically p/w gradual loss of renal function, & involves renal medulla with sparing of cortex.
#renalpath #pathsky #nephsky #medsky
April 7, 2025 at 4:26 AM
Patient w AKI. Biopsy of mostly medulla shows what appears at first to be pyelonephritis. Lots of neutrophils in medulla and no crescents. IF: negative.
BUT...there are areas of interstitial hemorrhage🤔
ANCA came back positive!😮
-->Medullary angiitis in ANCA vasculitis
#renalpath #pathsky #nephsky
April 7, 2025 at 4:22 AM
AA amyloidosis in setting of Rheumatoid Arthritis.
*Congo red: Birefringence under polarized light typical of amyloid
*LM: Lots of smudgy amorphous amyloid deposits everywhere!
*IHC: SAA+
*Mass spectrometry confirmed.
*AA can present in long-standing RA>15 years
#renalpath #pathsky #nephsky
April 7, 2025 at 4:17 AM
Adenovirus infection in a kidney allograft.
*Severe interstitial inflammation with poorly formed granulomas and necrosis.
*Total destruction of tubules with nuclear viral cytopathic changes.
*IHC helps confirm adenovirus.
#Infection_transplant #renalpath #pathsky #nephsky #medsky
April 7, 2025 at 4:10 AM
Patient with sarcoidosis p/w hypercalcemia and renal insufficiency.

Nephrocalcinosis
Multiple intratubular calcium oxalate and calcium phosphate crystals. Pic#2 shows calcium oxalate under polarized light. No granulomas.
#renalpath #sarcoidosis #nephrocalcinosis #pathsky #nephsky #medsky
April 7, 2025 at 4:06 AM
Worsening renal function after a carotid endarterectomy. Atherosclerotic plaque gets dislodged and the pieces form emboli; typically in those with severe PVD & can arise spontaneously or after invasive vascular procedure. #atheroembolus #renalpath #pathsky #nephsky #medsky
April 7, 2025 at 4:01 AM
Silver stain showing transplant glomerulopathy
April 7, 2025 at 3:56 AM
Corresponding EM shows randomly disposed fibrils replacing GBM and arranged in spikes/spicules
#renalpath
April 7, 2025 at 3:55 AM
Jones silver stain showing "eyelash sign" - spicular projection of the GBMs towards the urinary space in AL amyloidosis. Visible on PAS too

#renalpath #hemepath #pathsky #nephsky #medsky
April 7, 2025 at 3:55 AM
Chronic active ABMR in patient with worsening proteinuria, renal function, positive DSA

*Glomerulitis (shown in image)
*Transplant glomerulopathy (shown in image)
*Peritubular capillaritis
*Diffuse C4d+ in PTCs on IF
#renalpath #transplant #pathsky #nephsky #medsky
April 7, 2025 at 3:50 AM
Chronic allograft arteriopathy - fibrous intimal thickening with inflammatory cells in intima with foam cells. Hallmark of chronic rejection.
#renalpath #transplant #pathsky #nephsky #medsky
April 7, 2025 at 3:45 AM
Young pt with h/o strep pharyngitis p/w several days malaise, abd pain, & oliguria w dark brown urine

Acute post-step/post-infectious GN
LM: Exudative GN,
IF: C3-dominant "starry sky" & "garland" pattern
EM: Hump-like subepithelial deposits (blue arrows)
#renalpath #pathsky #nephsky #medsky
April 7, 2025 at 3:41 AM
Patient with fever, chills, pain in extremities, TIA-like sx, & +ANCA. Bx'ed for presumed vasculitis, but found this instead--> Vacuolated podocytes which contain myeloid or "zebra bodies" by EM
Led to genetic testing confirming fabry disease
#renalpath #nephsky #pathsky #medsky
April 5, 2025 at 3:53 AM
Pt has DM, heavy proteinuria & CKD. Bx shows fx of nodular diabetic GS. BUT EM also shows large substructures. IF with strong fibrinogen in similar glomerular distribution as substructures. Other than linear weak IgG & albumin, Ig's & LC's (-). What could they be?
#renalpath #pathsky #nephsky
April 5, 2025 at 3:44 AM
Adenoviral particles by electron microscopy of infected tubular epithelial nuclei. The particles are crowded together and arranged in crystalline arrays. #renalpath #pathsky #nephsky #medsky
April 5, 2025 at 3:40 AM
A case of DENGAN (dengue nephropathy)

Patient had severe proteinuria & ARF
Bx showed collapsing glomerulopathy...
pubmed.ncbi.nlm.nih.gov/31198534/
#renalpath #nephsky #pathsky #medsky
April 5, 2025 at 3:36 AM