#renalpath #kidneydisease
opinions are my own
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Massive fibronectin deposits
🔸AD mutation FN1
🔸MPGN-like pattern
🔸Silver-neg, PAS+, trichrome-red
🔸EM: Homogeneous granular + variable fibrils
🔸IF/IHC strongly + fibronectin
🔸renal-limited
(1/2) more below
#renalpath #pathsky #nephsky
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
🔸Rare type of tubulointerstitial nephritis
🔸Strong linear polyclonal IgG restricted to TBMs
🔸No deposits by EM
🔸Autoantibody to TIN-ag in proximal TBM
🔸AKI/CKD, polyuria, polydipsia
Reference: ajkd.org/article/s027...
#renalpath #pathsky #nephsky
Notice randomly arranged fibrils in the subepithelial regions. DNAJB9-positivity is seen in a similar distribution by IHC. Can be mistaken for membranous nephropathy: doi.org/10.1016/j.ekir…#renalpatht#pathskyk#nephskyky
Notice randomly arranged fibrils in the subepithelial regions. DNAJB9-positivity is seen in a similar distribution by IHC. Can be mistaken for membranous nephropathy: doi.org/10.1016/j.ekir…#renalpatht#pathskyk#nephskyky
🔹Onion-skin type intimal fibrosis
🔹Mucointimal edema
🔹Endothelial cell enlargement
🔹Fragmented RBCs
🔹Fibrin thrombi & fibrin in intima
DD:
*Malignant HTN
*Scleroderma
*Other causes of TMA (e.g., aHUS, anti-phosphlipid, etc)
#renalpath #pathsky #nephsky #medsky
🔹Onion-skin type intimal fibrosis
🔹Mucointimal edema
🔹Endothelial cell enlargement
🔹Fragmented RBCs
🔹Fibrin thrombi & fibrin in intima
DD:
*Malignant HTN
*Scleroderma
*Other causes of TMA (e.g., aHUS, anti-phosphlipid, etc)
#renalpath #pathsky #nephsky #medsky
•Often associated with lymphoproliferative disorder
•IF: Often clonal IgG & K/L-restricted
•EM: Hollow microtubules arranged in “parallel stacked arrays” or bundles
•Mean diameter 40 nm (20-60)
•Cryogloblins should be excluded
#renalpath #pathsky #nephsky #medsky
•Often associated with lymphoproliferative disorder
•IF: Often clonal IgG & K/L-restricted
•EM: Hollow microtubules arranged in “parallel stacked arrays” or bundles
•Mean diameter 40 nm (20-60)
•Cryogloblins should be excluded
#renalpath #pathsky #nephsky #medsky
LM: Discrete well-formed non-necrotizing granulomas
Granulomatous TIN differential:
•Sarcoidosis
•Infections (TB, fungus)
•Reaction to ruptured tubules in AIN
•Foreign body reaction
•Vasculitis (ANCA)
#renalpath #pathsky #nephsky #medsky
LM: Discrete well-formed non-necrotizing granulomas
Granulomatous TIN differential:
•Sarcoidosis
•Infections (TB, fungus)
•Reaction to ruptured tubules in AIN
•Foreign body reaction
•Vasculitis (ANCA)
#renalpath #pathsky #nephsky #medsky
•Rare cause of AKI in monocytic leukemias
•Proximal tubules have hypereosinophilic granular cytoplasm, which are PAS +/- & silver➖
•IHC stain: lysozyme strongly➕in cytoplasm
•EM:⬆️# of lysosomes with electron dense stuff
#renalpath #nephsky, #pathsky #medsky
•Rare cause of AKI in monocytic leukemias
•Proximal tubules have hypereosinophilic granular cytoplasm, which are PAS +/- & silver➖
•IHC stain: lysozyme strongly➕in cytoplasm
•EM:⬆️# of lysosomes with electron dense stuff
#renalpath #nephsky, #pathsky #medsky
Megakaryocytes in glomerular capillaries & features of glomerular TMA
Other path fx: Mesangial sclerosis & hypercellularity, & FSGS
Clinically: proteinuria & renal dysfxn pubmed.ncbi.nlm.nih.gov/21654720/
#renalpath #nephsky #pathsky #medsky
Megakaryocytes in glomerular capillaries & features of glomerular TMA
Other path fx: Mesangial sclerosis & hypercellularity, & FSGS
Clinically: proteinuria & renal dysfxn pubmed.ncbi.nlm.nih.gov/21654720/
#renalpath #nephsky #pathsky #medsky
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
Extramedullary hematopoiesis
•Hematopoietic tissue outside BM
•Due to hematologic malignancy/lack BM hematopoiesis (HP)
•Histology: TIN + trilineage HP
#renalpath #pathsky #nephsky #hemepath
Congo red-positive.
IF is (-) for kappa & lambda.
Mass spectrometry --> Apolipoprotein A-IV
Very rare type of amyloidosis, typically p/w gradual loss of renal function, & involves renal medulla with sparing of cortex.
#renalpath #pathsky #nephsky #medsky
Congo red-positive.
IF is (-) for kappa & lambda.
Mass spectrometry --> Apolipoprotein A-IV
Very rare type of amyloidosis, typically p/w gradual loss of renal function, & involves renal medulla with sparing of cortex.
#renalpath #pathsky #nephsky #medsky
BUT...there are areas of interstitial hemorrhage🤔
ANCA came back positive!😮
-->Medullary angiitis in ANCA vasculitis
#renalpath #pathsky #nephsky
BUT...there are areas of interstitial hemorrhage🤔
ANCA came back positive!😮
-->Medullary angiitis in ANCA vasculitis
#renalpath #pathsky #nephsky
*Congo red: Birefringence under polarized light typical of amyloid
*LM: Lots of smudgy amorphous amyloid deposits everywhere!
*IHC: SAA+
*Mass spectrometry confirmed.
*AA can present in long-standing RA>15 years
#renalpath #pathsky #nephsky
*Congo red: Birefringence under polarized light typical of amyloid
*LM: Lots of smudgy amorphous amyloid deposits everywhere!
*IHC: SAA+
*Mass spectrometry confirmed.
*AA can present in long-standing RA>15 years
#renalpath #pathsky #nephsky
*Severe interstitial inflammation with poorly formed granulomas and necrosis.
*Total destruction of tubules with nuclear viral cytopathic changes.
*IHC helps confirm adenovirus.
#Infection_transplant #renalpath #pathsky #nephsky #medsky
*Severe interstitial inflammation with poorly formed granulomas and necrosis.
*Total destruction of tubules with nuclear viral cytopathic changes.
*IHC helps confirm adenovirus.
#Infection_transplant #renalpath #pathsky #nephsky #medsky
Nephrocalcinosis
Multiple intratubular calcium oxalate and calcium phosphate crystals. Pic#2 shows calcium oxalate under polarized light. No granulomas.
#renalpath #sarcoidosis #nephrocalcinosis #pathsky #nephsky #medsky
Nephrocalcinosis
Multiple intratubular calcium oxalate and calcium phosphate crystals. Pic#2 shows calcium oxalate under polarized light. No granulomas.
#renalpath #sarcoidosis #nephrocalcinosis #pathsky #nephsky #medsky
#renalpath
#renalpath
#renalpath #hemepath #pathsky #nephsky #medsky
#renalpath #hemepath #pathsky #nephsky #medsky
*Glomerulitis (shown in image)
*Transplant glomerulopathy (shown in image)
*Peritubular capillaritis
*Diffuse C4d+ in PTCs on IF
#renalpath #transplant #pathsky #nephsky #medsky
*Glomerulitis (shown in image)
*Transplant glomerulopathy (shown in image)
*Peritubular capillaritis
*Diffuse C4d+ in PTCs on IF
#renalpath #transplant #pathsky #nephsky #medsky
#renalpath #transplant #pathsky #nephsky #medsky
#renalpath #transplant #pathsky #nephsky #medsky
Acute post-step/post-infectious GN
LM: Exudative GN,
IF: C3-dominant "starry sky" & "garland" pattern
EM: Hump-like subepithelial deposits (blue arrows)
#renalpath #pathsky #nephsky #medsky
Acute post-step/post-infectious GN
LM: Exudative GN,
IF: C3-dominant "starry sky" & "garland" pattern
EM: Hump-like subepithelial deposits (blue arrows)
#renalpath #pathsky #nephsky #medsky
Led to genetic testing confirming fabry disease
#renalpath #nephsky #pathsky #medsky
Led to genetic testing confirming fabry disease
#renalpath #nephsky #pathsky #medsky
#renalpath #pathsky #nephsky
#renalpath #pathsky #nephsky
Patient had severe proteinuria & ARF
Bx showed collapsing glomerulopathy...
pubmed.ncbi.nlm.nih.gov/31198534/
#renalpath #nephsky #pathsky #medsky
Patient had severe proteinuria & ARF
Bx showed collapsing glomerulopathy...
pubmed.ncbi.nlm.nih.gov/31198534/
#renalpath #nephsky #pathsky #medsky