Gabriel Negreira
@gnegreira.bsky.social
#Leishmaniac, #FWO junior postdoc at @itmantwerp.bsky.social.
Using #singlecellgenomics to understand Aneuploidy and Genome instability in #Leishmania.
Using #singlecellgenomics to understand Aneuploidy and Genome instability in #Leishmania.
(6/6)
We also revealed a previously unknown population heterogeneity in a #Leishmania strain which is commonly used in laboratory research.
We also revealed a previously unknown population heterogeneity in a #Leishmania strain which is commonly used in laboratory research.
September 11, 2025 at 10:15 AM
(6/6)
We also revealed a previously unknown population heterogeneity in a #Leishmania strain which is commonly used in laboratory research.
We also revealed a previously unknown population heterogeneity in a #Leishmania strain which is commonly used in laboratory research.
(5/6)
In our latest preprint, we combined Semi-permeable capsules ( #SPCs ) with #PTA to sequence the DNA of individual #Leishmania parasites at high throughput, identifying multiple layers of genetic heterogeneity, from mosaic aneuploidy to variations in the sequence of drug-resistance genes.
In our latest preprint, we combined Semi-permeable capsules ( #SPCs ) with #PTA to sequence the DNA of individual #Leishmania parasites at high throughput, identifying multiple layers of genetic heterogeneity, from mosaic aneuploidy to variations in the sequence of drug-resistance genes.
September 11, 2025 at 10:15 AM
(5/6)
In our latest preprint, we combined Semi-permeable capsules ( #SPCs ) with #PTA to sequence the DNA of individual #Leishmania parasites at high throughput, identifying multiple layers of genetic heterogeneity, from mosaic aneuploidy to variations in the sequence of drug-resistance genes.
In our latest preprint, we combined Semi-permeable capsules ( #SPCs ) with #PTA to sequence the DNA of individual #Leishmania parasites at high throughput, identifying multiple layers of genetic heterogeneity, from mosaic aneuploidy to variations in the sequence of drug-resistance genes.
Happy to share our latest preprint, where we present a novel high-throughput #single-cell DNA method that resolves genomic heterogeneity in #Leishmania, from #aneuploidy, #CNVs to #drug-resistance mutations.
🧵...
Link here: www.biorxiv.org/content/10.1...
🧵...
Link here: www.biorxiv.org/content/10.1...
September 11, 2025 at 10:15 AM
Happy to share our latest preprint, where we present a novel high-throughput #single-cell DNA method that resolves genomic heterogeneity in #Leishmania, from #aneuploidy, #CNVs to #drug-resistance mutations.
🧵...
Link here: www.biorxiv.org/content/10.1...
🧵...
Link here: www.biorxiv.org/content/10.1...