Gabriel Negreira
@gnegreira.bsky.social
#Leishmaniac, #FWO junior postdoc at @itmantwerp.bsky.social.
Using #singlecellgenomics to understand Aneuploidy and Genome instability in #Leishmania.
Using #singlecellgenomics to understand Aneuploidy and Genome instability in #Leishmania.
Happy to share our latest preprint, where we present a novel high-throughput #single-cell DNA method that resolves genomic heterogeneity in #Leishmania, from #aneuploidy, #CNVs to #drug-resistance mutations.
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Link here: www.biorxiv.org/content/10.1...
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Link here: www.biorxiv.org/content/10.1...
September 11, 2025 at 10:15 AM
Happy to share our latest preprint, where we present a novel high-throughput #single-cell DNA method that resolves genomic heterogeneity in #Leishmania, from #aneuploidy, #CNVs to #drug-resistance mutations.
🧵...
Link here: www.biorxiv.org/content/10.1...
🧵...
Link here: www.biorxiv.org/content/10.1...
Reposted by Gabriel Negreira
Drs Kyrie Dickson, Jaime Costales, Malgorzata Domagalska, Ferre Veken & Martin Llewellyn discuss #genome (dis)organisation in #Trypanosoma #cruzi: innovation through #instability? #Adaptation #Chagas #Aneuploidy #Trypanosomatids
www.cell.com/trends/paras...
www.cell.com/trends/paras...
May 27, 2025 at 10:02 AM
Drs Kyrie Dickson, Jaime Costales, Malgorzata Domagalska, Ferre Veken & Martin Llewellyn discuss #genome (dis)organisation in #Trypanosoma #cruzi: innovation through #instability? #Adaptation #Chagas #Aneuploidy #Trypanosomatids
www.cell.com/trends/paras...
www.cell.com/trends/paras...
Reposted by Gabriel Negreira
Please enjoy a new paper led by @jezieldamasceno.bsky.social that reveals how R-loops and their homeostatsis through RNase H1 modulate Leishmania DNA replication timing @uofgsii.bsky.social @marquescata.bsky.social @scotomorph.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania - Nature Communications
All genomes are replicated in a temporal order, though the determinants of such timing are poorly characterized. Here, the authors show that the unusual chromosome size-dependent DNA replication timin...
www.nature.com
February 10, 2025 at 12:33 PM
Please enjoy a new paper led by @jezieldamasceno.bsky.social that reveals how R-loops and their homeostatsis through RNase H1 modulate Leishmania DNA replication timing @uofgsii.bsky.social @marquescata.bsky.social @scotomorph.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gabriel Negreira
🌍Did you know visceral leishmaniasis claims thousands of lives each year in East Africa? In light of this World NTD Day, ITM alumnus Ermias Diro will shed light on the challenges and solutions to eliminate this disease. Reserve your spot today!👉 bit.ly/3PJfzM0 #EndNTDs
January 21, 2025 at 10:59 AM
🌍Did you know visceral leishmaniasis claims thousands of lives each year in East Africa? In light of this World NTD Day, ITM alumnus Ermias Diro will shed light on the challenges and solutions to eliminate this disease. Reserve your spot today!👉 bit.ly/3PJfzM0 #EndNTDs