Dylan Glubb
@glubbster.bsky.social
Functional geneticist 🧬 working on #endometrialcancer @QIMRBerghofer. IPA fan (the beer 🍺 , not the pathway analysis) from Chch 🇳🇿. Views are my own.
Our study revealed 37 genes with robust causal links to #CRC risk using 3 different TWAS approaches. 10 of these genes are novel findings not previously reported by TWAS. This significantly expands our understanding of CRC's genetic susceptibility. 🧬 #GeneDiscovery 4/7
June 9, 2025 at 5:48 AM
Our study revealed 37 genes with robust causal links to #CRC risk using 3 different TWAS approaches. 10 of these genes are novel findings not previously reported by TWAS. This significantly expands our understanding of CRC's genetic susceptibility. 🧬 #GeneDiscovery 4/7
How? Large-scale TWAS across 6 relevant tissues, integrating expression & splicing data with Mendelian randomisation & colocalisation. Data from 52,775 CRC cases & 45,940 controls powered our findings. 🔬 #TWAS #Epidemiology #Splicing 3/7
June 9, 2025 at 5:48 AM
How? Large-scale TWAS across 6 relevant tissues, integrating expression & splicing data with Mendelian randomisation & colocalisation. Data from 52,775 CRC cases & 45,940 controls powered our findings. 🔬 #TWAS #Epidemiology #Splicing 3/7
New insights into #ColorectalCancer from TWAS led by @emmahazelwood.bsky.social and @drtracy.bsky.social (@qimrb.bsky.social). Thread 👇 1/7
June 9, 2025 at 5:48 AM
New insights into #ColorectalCancer from TWAS led by @emmahazelwood.bsky.social and @drtracy.bsky.social (@qimrb.bsky.social). Thread 👇 1/7