Gabriele Laudadio
@glaudadio.bsky.social
Organic Chemist, Group Leader E-Chem Team UniGraz | Postdoc at BaranLab | PhD in Noël Group
2022 #CASFutureLeader, 2021 #RealTimeChem Ambassador.
ORCiD: https://orcid.org/0000-0002-2749-8393
2022 #CASFutureLeader, 2021 #RealTimeChem Ambassador.
ORCiD: https://orcid.org/0000-0002-2749-8393
Could we please avoid comparison? I am sensitive to this. Calzone IS NOT an empanada. They are both delicious, but in different ways 🤣🤣🤣
November 17, 2025 at 5:52 PM
Could we please avoid comparison? I am sensitive to this. Calzone IS NOT an empanada. They are both delicious, but in different ways 🤣🤣🤣
I think this initiative was more to have an AI that can spark constructive criticism on a scientific work, rather than a mere expedient to circumvent our duty as peer-reviewers. As always, it depends on how you use the tool, isn't it?
October 17, 2025 at 8:43 AM
I think this initiative was more to have an AI that can spark constructive criticism on a scientific work, rather than a mere expedient to circumvent our duty as peer-reviewers. As always, it depends on how you use the tool, isn't it?
I totally agree John, it happened to me to receive sus peer review, but how would you prove it? I mean, how could I sustain the argumentation of an alleged AI peer-review? :(
October 17, 2025 at 8:41 AM
I totally agree John, it happened to me to receive sus peer review, but how would you prove it? I mean, how could I sustain the argumentation of an alleged AI peer-review? :(
I totally agree... MOF has been in the shortlist for a while...
October 7, 2025 at 9:15 AM
I totally agree... MOF has been in the shortlist for a while...
Since the review is about the modular nature of these platforms and how they were exploited in the literature, puzzle pieces came up pretty naturally. My biggest problem was filling the lab bench in back 😬
September 19, 2025 at 12:56 PM
Since the review is about the modular nature of these platforms and how they were exploited in the literature, puzzle pieces came up pretty naturally. My biggest problem was filling the lab bench in back 😬
Thanks for the kind words! The idea of the e-chem robot dreaming about automating itself was something that was bugging my head for a while! That was where the whole concept started :)
September 19, 2025 at 12:34 PM
Thanks for the kind words! The idea of the e-chem robot dreaming about automating itself was something that was bugging my head for a while! That was where the whole concept started :)
I had a lot of fun designing the cover. It started from a simple concept: I wanted to revisit a classic in sci-fi literature. My wife sketched the idea for me, the rest is history :) #chemsky
September 15, 2025 at 3:00 PM
I had a lot of fun designing the cover. It started from a simple concept: I wanted to revisit a classic in sci-fi literature. My wife sketched the idea for me, the rest is history :) #chemsky
And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)
(12/12)
(12/12)
September 10, 2025 at 3:01 PM
And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)
(12/12)
(12/12)
It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.
(11/n)
(11/n)
September 10, 2025 at 3:01 PM
It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.
(11/n)
(11/n)
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
September 10, 2025 at 3:01 PM
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
September 10, 2025 at 3:01 PM
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
During the scope we identified some key requirements for successful substrates... (8/n)
September 10, 2025 at 3:01 PM
During the scope we identified some key requirements for successful substrates... (8/n)
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
September 10, 2025 at 3:01 PM
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
September 10, 2025 at 3:01 PM
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
... Why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
September 10, 2025 at 3:01 PM
... Why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
September 10, 2025 at 3:01 PM
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
September 10, 2025 at 3:01 PM
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
September 10, 2025 at 3:01 PM
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)
(12/12)
(12/12)
September 10, 2025 at 2:55 PM
And this is the story of how we turned something theoretically really cool into something synthetically useful. An elusive intermediate chased for 60 years :)
(12/12)
(12/12)
It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.
(11/n)
(11/n)
September 10, 2025 at 2:55 PM
It seems that without the electrochemical polishing of the magnesium electrode, the reaction cannot take place. Weird enough, a reduction at the anode.
(11/n)
(11/n)
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
September 10, 2025 at 2:55 PM
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
September 10, 2025 at 2:55 PM
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)