Gabriele Laudadio
@glaudadio.bsky.social
Organic Chemist, Group Leader E-Chem Team UniGraz | Postdoc at BaranLab | PhD in Noël Group
2022 #CASFutureLeader, 2021 #RealTimeChem Ambassador.
ORCiD: https://orcid.org/0000-0002-2749-8393
2022 #CASFutureLeader, 2021 #RealTimeChem Ambassador.
ORCiD: https://orcid.org/0000-0002-2749-8393
I had a lot of fun designing the cover. It started from a simple concept: I wanted to revisit a classic in sci-fi literature. My wife sketched the idea for me, the rest is history :) #chemsky
September 15, 2025 at 3:00 PM
I had a lot of fun designing the cover. It started from a simple concept: I wanted to revisit a classic in sci-fi literature. My wife sketched the idea for me, the rest is history :) #chemsky
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
September 10, 2025 at 3:01 PM
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
September 10, 2025 at 3:01 PM
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
During the scope we identified some key requirements for successful substrates... (8/n)
September 10, 2025 at 3:01 PM
During the scope we identified some key requirements for successful substrates... (8/n)
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
September 10, 2025 at 3:01 PM
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
September 10, 2025 at 3:01 PM
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
... Why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
September 10, 2025 at 3:01 PM
... Why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
September 10, 2025 at 3:01 PM
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
September 10, 2025 at 3:01 PM
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
September 10, 2025 at 3:01 PM
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
We are proud to present our work on something really special, appeared in
@ChemRxiv
today. We unlocked the synthetic application of DMF distonic radical anion with electrochemistry!
Interested in the full story? See below! (1/n)
chemrxiv.org/engage/chemr...
@ChemRxiv
today. We unlocked the synthetic application of DMF distonic radical anion with electrochemistry!
Interested in the full story? See below! (1/n)
chemrxiv.org/engage/chemr...
September 10, 2025 at 3:01 PM
We are proud to present our work on something really special, appeared in
@ChemRxiv
today. We unlocked the synthetic application of DMF distonic radical anion with electrochemistry!
Interested in the full story? See below! (1/n)
chemrxiv.org/engage/chemr...
@ChemRxiv
today. We unlocked the synthetic application of DMF distonic radical anion with electrochemistry!
Interested in the full story? See below! (1/n)
chemrxiv.org/engage/chemr...
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
September 10, 2025 at 2:55 PM
Turned out that it's the Mg of the sacrificial anode that does the job (as Perichon hypothesized)! It has sufficient redox potential to do it, but the constant refresh of the Mg surface is crucial to the success of the reaction. (10/n)
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
September 10, 2025 at 2:55 PM
And finally, we landed on the mechanistic investigation. We proved the radical formation and the radical attack (see the key experiment with beta-caryophyllene).
But if the potential required is so low, how can this work?? (9/n)
But if the potential required is so low, how can this work?? (9/n)
During the scope we identified some key requirements for successful substrates... (8/n)
September 10, 2025 at 2:55 PM
During the scope we identified some key requirements for successful substrates... (8/n)
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
September 10, 2025 at 2:55 PM
Then we went for the scope, Yifan and Sulekha (the real stars of this project) unleashed their creativity and they worked with some wild monsters... Along with a two-step-one-pot system to reduce the enamine to perform hydroaminomethylation and consecutive homologation (7/n)
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
September 10, 2025 at 2:55 PM
So we spent some time on it, and after a while, we achieved our desired hydroformylated product. Interestingly, all the thermal controls did not work. (6/n)
... But why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
September 10, 2025 at 2:55 PM
... But why is this radical so elusive? While HAT intermediates are relatively easy to obtain, direct SET reduction is a completely different deal, just look at the CV. This is the reason why it is one of the solvents of choice for cathodic reactions. (5/n)
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
September 10, 2025 at 2:55 PM
But there was somebody else who obtained some dimers from DMF... One of the giants of electrochemistry, Dr. Jacques Perichon.
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
He observed something weird. His Mg sacrificial electrodes were consumed much more than they should have been... (4/n)
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
September 10, 2025 at 2:55 PM
In 2012, Shkrob and Marin explored the radiolysis of formamides via EPR, obtaining spectroscopic evidence of a new radical species (Radical X)... They hypothesized that the existence of a reduced species of DMF, which could exist only in its solvated form... (3/n)
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
September 10, 2025 at 2:55 PM
In 1965, Prof. Bredereck found out that boiling formamides with Li, Na, or K (fun, isn't it?) you may get some weird dimers... (2/n)
August 26, 2025 at 5:50 AM
Today in our group meeting we discussed the first issue of @angewandtechemie.bsky.social #AngewandteChemieNovit
Lots of great chemistry already there!
Lots of great chemistry already there!
August 8, 2025 at 8:41 AM
Today in our group meeting we discussed the first issue of @angewandtechemie.bsky.social #AngewandteChemieNovit
Lots of great chemistry already there!
Lots of great chemistry already there!
Check out our latest contribution in
ChemElectroChem: a work on intensifying the electrochemical hydrocarboxylation of activated alkenes. Interesting findings regarding the impact of current density on reaction selectivity!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
ChemElectroChem: a work on intensifying the electrochemical hydrocarboxylation of activated alkenes. Interesting findings regarding the impact of current density on reaction selectivity!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
July 10, 2025 at 10:43 AM
Check out our latest contribution in
ChemElectroChem: a work on intensifying the electrochemical hydrocarboxylation of activated alkenes. Interesting findings regarding the impact of current density on reaction selectivity!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
ChemElectroChem: a work on intensifying the electrochemical hydrocarboxylation of activated alkenes. Interesting findings regarding the impact of current density on reaction selectivity!
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Now that #IFCS2025 came to an end, I am nothing but grateful for the opportunity of meeting so many great scientists, attending insightful presentations, and discussing chemistry with the new generations.
Special thanks to the committee for inviting me to this event.
Special thanks to the committee for inviting me to this event.
May 10, 2025 at 4:42 AM
Now that #IFCS2025 came to an end, I am nothing but grateful for the opportunity of meeting so many great scientists, attending insightful presentations, and discussing chemistry with the new generations.
Special thanks to the committee for inviting me to this event.
Special thanks to the committee for inviting me to this event.
CASE STUDY 3: A decarboxylative Minisci reaction using Quinine as radical acceptor. Two different acids were proposed to the BO system. When the optimization was tested on different RAEs, we could identify key parameters crucial for the optimal result of each substrate. (5/n)
April 30, 2025 at 3:40 PM
CASE STUDY 3: A decarboxylative Minisci reaction using Quinine as radical acceptor. Two different acids were proposed to the BO system. When the optimization was tested on different RAEs, we could identify key parameters crucial for the optimal result of each substrate. (5/n)