The new vessel-on-a-chip can be used to further investigate IA, and possibly to develop therapeutics that improve vascular health!

Image: Megan Morris/Schulich Medicine & Dentistry

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This microscopic process has been very challenging to visualise in live animals, so Dr. Sabrina engineered a “vessel-on-a-chip” that could be imaged with high-powered microscopes. She captured how a single cell moves to split the vessel interior for the first time with these techniques!

Most research has focused on the “sprouting” method (where new blood vessels grow like branches sprouting from a tree), but IA forms new blood vessels by splitting an existing vessel in two.

Her research revealed the “hidden choreography” of an under-studied mechanism of blood vessel growth, or intussusceptive angiogenesis (IA).

She followed her passion all the way to her PhD where she used live-cell microscopy to study blood vessels!

Dr. Sabrina studied vascular regeneration–that’s how the body grows and repairs blood vessels–and recently made a big discovery!

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Image: National Marine Sanctuaries, Public domain, via Wikimedia Commons

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This is a big development, since typical reef restoration efforts have focused on increasing the amount of larvae in the ocean and have a poor survival rate. The discovery of the importance of early nutrition is another tool in the reef restoration toolbox and the fight against climate change!

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Please join us in remembering and honouring this dynamic trailblazer and leader. Read more about Dr. McGregor here: Clubhouse.GirlsInScience.ca/Remembering-Betsy-McGregor/

Her book, Women on the Ballot: Pathways to Political Power, features 94 of Canada’s best known women trailblazers in politics, containing diverse strategies and skills to equip and empower women and other individuals from underrepresented groups of all ages entering politics.

Her advocacy for gender equity also extended to politics, leadership, technology and the trades.

In 1987, Dr. McGregor, a veterinarian by training, founded the World Women’s Veterinary Association to tackle rural poverty, internationally, and “support women’s role in agriculture as pivotal to food security and environmental sustainability.”

As Deputy Director of the Research Gender Institute within the Canadian Institute for Health Research, she worked on advancing gender equity in science and agriculture, women’s health research, and the protection of Indigenous knowledge systems.

For example, as Director of Studies for the UN-CSTD “Gender Working Group”, she helped drive the Declaration of Intent tabled at the 1995 UN Beijing Fourth World Conference on Women, and the book Missing Links with the International Development Research Centre.

Dr. McGregor spent much of her early career working in international development with the United Nations (UN) and the Government of Canada, effecting change in many capacities.

Dr. McGregor was a long-time CAGIS supporter and donor, had served on the CAGIS Board of Directors, and provided mentorship to CAGIS leadership. She was also a Member of the Order of Canada in recognition of her decades of service, especially advancing youth, diversity, and women in leadership.

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