@giglionelab.bsky.social
Reposted
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
October 26, 2025 at 6:59 PM
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
Reposted
A conference about #proteostasis in a palazzo in Palermo; inclusive, affordable, and organised by the marvellous @giglionelab.bsky.social - what’s not to like? Oh, and there is a fantastic lineup of talks plus slots to spare #ProteinTermini2026
See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026
October 26, 2025 at 8:48 PM
A conference about #proteostasis in a palazzo in Palermo; inclusive, affordable, and organised by the marvellous @giglionelab.bsky.social - what’s not to like? Oh, and there is a fantastic lineup of talks plus slots to spare #ProteinTermini2026
Reposted
Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
September 23, 2025 at 7:38 AM
Developing leaves form a spatiotemporal oxygen gradient that is sensed through the oxygen sensing machinery and directs morphogenesis | New preprint from @daanweits.bsky.social and @syno2xis.bsky.social labs #N-degron #Cysteine #hypoxia @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Reposted
Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
Methods in Enzymology | Volume 719: Protein Termini - Part B | ScienceDirect.com by Elsevier
Read the latest chapters of Methods in Enzymology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
www.sciencedirect.com
September 25, 2025 at 9:17 AM
Two new volumes of Methods in Enzymology with 29 chapters/papers on Protein termini methods and reviews are now out! Thx to all authors!🙌 @ispt-proteinterm.bsky.social #N-degron #prenylation #myristoylation #formylation #arginylation #oxidation #acetylation www.sciencedirect.com/bookseries/m...
Reposted
Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...
September 25, 2025 at 9:45 AM
Protein N-terminal acetylation regulates the growth of rice plants | #NAA30 #NatC #rice #acetylation www.sciencedirect.com/science/arti...
Reposted
Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.
We have just published a paper in Genome Biology, rdcu.be/eIMLf. We explore the information flow between genome, gene body methylation, transcriptome, translatome and proteome in Arabidopsis. This is part of a BBSRC-funded collaboration with UCL, Rothamsted Research and University of Cambridge.
September 30, 2025 at 9:56 AM
Happy to share that our multi-omic analysis comparing two Arabidopsis accessions is now published 🌿 The first story from our @ukri.org BBSRC sLoLa #plant #proteostasis project. A great collaboration between @rothamsted.bsky.social @richardmott.bsky.social @ucl.ac.uk and Kathryn Lilley at Cambridge.
Reposted
Delighted to invite applications for a PhD project in the group. Come and do some awesome biochemistry and physiology in a truly interdisciplinary team!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
PhD Studentship in Molecular Physiology – Protein-Protein Interactions and Therapeutic Targeting of Cardiac Ion Channels at University of Glasgow on FindAPhD.com
PhD Project - PhD Studentship in Molecular Physiology – Protein-Protein Interactions and Therapeutic Targeting of Cardiac Ion Channels at University of Glasgow, listed on FindAPhD.com
www.findaphd.com
October 2, 2025 at 9:41 PM
Delighted to invite applications for a PhD project in the group. Come and do some awesome biochemistry and physiology in a truly interdisciplinary team!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity
N-terminal acetyltransferase D (NatD) is a highly selective enzyme that acetylates the α-N-terminal amine of histones H4 and H2A, which share the SGRGK motif. Elevated NatD expression has been observe...
pubs.acs.org
October 5, 2025 at 12:07 PM
A Cell-Potent Bisubstrate Inhibitor to Probe NatD Acetyltransferase Activity | The inhibitor effectively reduced cellular Nα-acetylation on histone H4, leading to reduced migration in lung cancer cells | @acs.org ACS Chemical Biology @ispt-proteinterm.bsky.social pubs.acs.org/doi/10.1021/...
Reposted
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
NAA60 facilitates LRRC8A- and LRRC8D-mediated platinum drug uptake - Communications Biology
Genome-wide CRISPR/Cas9 screening identifies the N-terminal acetyltransferase NAA60 to facilitate cis- and carboplatin drug sensitivity, most likely by neutralizing Nt acetylation of the LRRC8A/D VRAC subunits regulating substrate permeability.
www.nature.com
October 7, 2025 at 11:03 AM
Uptake of anti-cancer drugs depends on N-terminally acetylated anion channels | @ispt-proteinterm.bsky.social www.nature.com/articles/s42...
Reposted
We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!
Lab website: sites.google.com/site/danielg...
Lab website: sites.google.com/site/danielg...
Daniel Gibbs Lab
Welcome to the lab website of Professor Daniel Gibbs
@ University of Birmingham
sites.google.com
October 14, 2025 at 2:07 PM
We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!
Lab website: sites.google.com/site/danielg...
Lab website: sites.google.com/site/danielg...
Reposted
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...
www.biorxiv.org
September 8, 2025 at 10:15 AM
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
Reposted
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons and the cytoplasmic aggregation of misfolded proteins in the spinal cord...
www.biorxiv.org
September 8, 2025 at 11:07 AM
Targeted degradation of pathogenic TDP-43 proteins in amyotrophic lateral sclerosis using the AUTOTAC platform | Yong Tae Kwon lab | #N-degron www.biorxiv.org/content/10.1...
Reposted
Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...
July 1, 2025 at 1:44 PM
Acetylhistidine in our blood can prevent kidney disease and is produced by the HisAT (NAT16) enzyme displaying a rare double-GNAT structure. Great efforts by Matti Myllykoski and the rest of the team at @unibergen.bsky.social to get this published. #acetyltransferase www.nature.com/articles/s41...
Reposted
How did oxygen-sensing evolve in plants?
In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk
“ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia”
www.cell.com/molecular-pl...
In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk
“ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia”
www.cell.com/molecular-pl...
ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia
Short summary:This study investigates the evolution of the low-oxygen response in
land plants mediated by group VII Ethylene Response Factors (ERFVIIs). We identified
conserved transcriptional signatu...
www.cell.com
May 28, 2025 at 8:21 AM
How did oxygen-sensing evolve in plants?
In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk
“ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia”
www.cell.com/molecular-pl...
In collaboration with @syno2xis.bsky.social Great work from @lauradc.bsky.social et. al. #plantscience @leverhulme.ac.uk
“ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia”
www.cell.com/molecular-pl...
Reposted
Protein acetylation as a novel post-translational modification of plant peroxisomal proteins. @ispt-proteinterm.bsky.social academic.oup.com/jxb/article-...
Protein acetylation as a novel post-translational modification of plant peroxisomal proteins
We summarize research data newly demonstrating that plant peroxisomal proteins are modified co- and post-translationally by acetylation, and we predict the
academic.oup.com
May 25, 2025 at 1:08 PM
Protein acetylation as a novel post-translational modification of plant peroxisomal proteins. @ispt-proteinterm.bsky.social academic.oup.com/jxb/article-...
Reposted
Two heroes of the COST ProteoCure network: Oliver Coux and Laetitia Poidevin. Many thanks from all of us! #ProteoCure2025 @costprogramme.bsky.social
May 26, 2025 at 10:29 AM
Two heroes of the COST ProteoCure network: Oliver Coux and Laetitia Poidevin. Many thanks from all of us! #ProteoCure2025 @costprogramme.bsky.social
Reposted
Reposted
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
'
my.corehr.com
May 24, 2025 at 5:29 AM
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
Reposted
Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Combinatorial mutagenesis of N-terminal sequences reveals unexpected and expanded stability determinants of the Escherichia coli N-degron pathway
Although it is known that penultimate N-terminal residues can influence protein stability by the N-degron pathway, there has not been a comprehensive effort to document nor predict these effects for n...
www.biorxiv.org
May 23, 2025 at 2:04 PM
Protein degradation in E. coli via N-terminal degradation signals (degrons) defined by the @kunjapur.bsky.social lab. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.1...
Reposted
Oxygen sensors structurally defined. The substrate binding of N-terminal cysteine oxidases uncovered by the White lab @drmdwhite.bsky.social in @natcomms.nature.com www.nature.com/articles/s41...
An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase - Nature Communications
This work identified cyclic peptide inhibitors of a mammalian N-terminal cysteine oxidase, ADO, through mRNA display, one of which was used as a scaffold to graft substrate moieties, allowing key inte...
www.nature.com
May 23, 2025 at 3:27 AM
Oxygen sensors structurally defined. The substrate binding of N-terminal cysteine oxidases uncovered by the White lab @drmdwhite.bsky.social in @natcomms.nature.com www.nature.com/articles/s41...
Reposted
Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
May 24, 2025 at 8:22 AM
Congrats to Corentin Bouvier, awardee of the FEBS Journal prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febsj.bsky.social #ProteoCure2025
Reposted
Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025
May 24, 2025 at 8:23 AM
Congrats to Mónica Pozo Rodriguez, awardee of the FEBS Open Bio Poster prize at the annual COST ProteoCure meeting. @costprogramme.bsky.social @febspress.bsky.social #ProteoCure2025
Reposted
Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting.
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
May 24, 2025 at 8:25 AM
Congrats to Simon Tack, awardee of the FEBS Journal Oral Presentation prize at the annual COST ProteoCure meeting.
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
@costprogramme.bsky.social @febsj.bsky.social
#ProteoCure2025
Reposted
Nobel Laureate Aaron Ciechanover gave a historic overview on the discovery of ubiquitylation and finished with some very recent data from his lab at the annual #ProteoCure meeting.
May 21, 2025 at 7:57 AM
Nobel Laureate Aaron Ciechanover gave a historic overview on the discovery of ubiquitylation and finished with some very recent data from his lab at the annual #ProteoCure meeting.