Gregor Hagelueken
@gha14.bsky.social
Structural Biologist. Likes Proteins - most of the time.
Thanks to @biancabroske.bsky.social , @scbinder.bsky.social , @tim-kempchen.bsky.social and all the other authors for a fantastic collaboration. A big thank you goes to the developers of #RFdiffusion, #Chroma, #Bindcraft and others to make these amazing algorithms available.
May 18, 2025 at 5:06 PM
Thanks to @biancabroske.bsky.social , @scbinder.bsky.social , @tim-kempchen.bsky.social and all the other authors for a fantastic collaboration. A big thank you goes to the developers of #RFdiffusion, #Chroma, #Bindcraft and others to make these amazing algorithms available.
We created a number of high affinitiy and highly specific #AI-Binders against several cancer surface proteins and converted them into easy to use #FACS reagents that we termed #Quattrobinders.
May 18, 2025 at 5:06 PM
We created a number of high affinitiy and highly specific #AI-Binders against several cancer surface proteins and converted them into easy to use #FACS reagents that we termed #Quattrobinders.
In close collaboration with the @mholzel-lab.bsky.social and @jsb-lab.bsky.social labs, we setup a scaleable AI-Binder design and validation pipeline.
May 18, 2025 at 5:06 PM
In close collaboration with the @mholzel-lab.bsky.social and @jsb-lab.bsky.social labs, we setup a scaleable AI-Binder design and validation pipeline.
When we saw the first tweats about #RFdiffusion and #Chroma, we wanted to try if we can apply these tools to our own research.
Have a look at our preprint and learn what worked out of the box and what didn't.
Have a look at our preprint and learn what worked out of the box and what didn't.
May 18, 2025 at 5:06 PM
When we saw the first tweats about #RFdiffusion and #Chroma, we wanted to try if we can apply these tools to our own research.
Have a look at our preprint and learn what worked out of the box and what didn't.
Have a look at our preprint and learn what worked out of the box and what didn't.
Reposted by Gregor Hagelueken
Please also check out another exciting work on AI-based protein design, which was a fantastic team effort with Michael Hölzel, @gha14.bsky.social, Tobias Bald and many colleagues at @unibonn.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...
www.biorxiv.org
May 16, 2025 at 7:21 PM
Please also check out another exciting work on AI-based protein design, which was a fantastic team effort with Michael Hölzel, @gha14.bsky.social, Tobias Bald and many colleagues at @unibonn.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...