Gigi Gronvall
@ggronvall.bsky.social
Professor, Johns Hopkins Bloomberg School of Public Health, Department of Environmental Health and Engineering, Center for Health Security
1st Hopkins prof to be a Marching Raven!
1st Hopkins prof to be a Marching Raven!
Emergency Caturday — so much medical disinformation, dumbness and meanness.
September 22, 2025 at 9:09 PM
Emergency Caturday — so much medical disinformation, dumbness and meanness.
Missing the days of potatoe.
September 9, 2025 at 8:23 PM
Missing the days of potatoe.
My smart cat is 23 pounds and is easy to catch — this is Sloopy
July 27, 2025 at 10:45 PM
My smart cat is 23 pounds and is easy to catch — this is Sloopy
Thanks for collecting all these cats in one thread. Here’s one of mine who doesn’t have much going on between her ears— Skiff
July 27, 2025 at 9:13 PM
Thanks for collecting all these cats in one thread. Here’s one of mine who doesn’t have much going on between her ears— Skiff
Happy Caturday from Sloopy!
July 19, 2025 at 12:16 PM
Happy Caturday from Sloopy!
Happy Caturday from Sloopy
June 21, 2025 at 2:15 PM
Happy Caturday from Sloopy
At least some people are happy 😬
June 12, 2025 at 2:42 PM
At least some people are happy 😬
Happy Caturday — picture of Sloopy from 5 years ago, today.
May 17, 2025 at 9:58 AM
Happy Caturday — picture of Sloopy from 5 years ago, today.
Listening to Todd Young (R-IN)’s smart remarks about how biotechnology is our nation’s future, and how important it is to implement the NSCEB report while reading fb posts from scientists who are losing training funds for emerging scientists and getting study sections canceled
April 10, 2025 at 1:30 PM
Listening to Todd Young (R-IN)’s smart remarks about how biotechnology is our nation’s future, and how important it is to implement the NSCEB report while reading fb posts from scientists who are losing training funds for emerging scientists and getting study sections canceled
No money for cancer research but
April 8, 2025 at 6:56 PM
No money for cancer research but
I was going to say it is my favorite but I think this one is:
April 3, 2025 at 9:15 PM
I was going to say it is my favorite but I think this one is:
There is only one quote from Alina Chan worth remembering.
March 23, 2025 at 8:12 PM
There is only one quote from Alina Chan worth remembering.
Skiff wishes you a peaceful Caturday.
March 22, 2025 at 1:31 PM
Skiff wishes you a peaceful Caturday.
One never knows where research can take you. Behold, the work (performed at NIH in 1982) that led to Ozempic/Wegovy. DOGE would prob kill this-- why would anyone care about Gila monster venom or guinea pig pancreases? Well, about 15 million Americans. How many future cures are being killed, now?
![screenshot of the pdf of this scientific article:
Actions of Gila monster venom on dispersed acini from guinea pig pancreas
Creator
Raufman, J. P.
Jensen, R. T.
Sutliff, V. E.
Pisano, J. J.
Gardner, J. D.
Is Part Of
American journal of physiology: Gastrointestinal and liver physiology, 1982-05, Vol.242 (5), p.G470-G474
Description
Venom from Gila monster (family Helodermatidae) contains a pancreatic secretagogue. In dispersed acini from guinea pig pancreas, the venom increased enzyme secretion to the same extent as did vasoactive intestinal peptide, secretin, or PHI. The abilities of vasoactive intestinal peptide and Gila monster venom to stimulate enzyme secretion were not altered by boiling but were abolished by incubation with trypsin or chymotrypsin. Like vasoactive intestinal peptide, secretin, and PHI, the venom caused a 50- to 60-fold increase in cellular cAMP and inhibited binding of 125I-vasoactive intestinal peptide to its membrane receptors on pancreatic acini. The action of venom on enzyme secretion was inhibited by [Gln9]secretin-(5-27), a vasoactive intestinal peptide receptor antagonist, but was not altered by atropine, a cholinergic receptor antagonist, or by dibutyryl cGMP, a cholecystokinin receptor antagonist. Gila monster venom contained no immunoreactive vasoactive intestinal peptide by radioimmunoassay. These results indicate that venom from Gila monster contains a peptide that can stimulate pancreatic enzyme secretion by interacting with vasoactive intestinal peptide receptors on pancreatic acinar cells and thereby activating adenylate cyclase and increasing cellular cAMP.
Identifier
ISSN: 0193-1857
EISSN: 1522-1547
DOI: 10.1152/ajpgi.1982.242.5.G470
Source
American Physiological Society Paid](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:tp7g7pgs5cagtgang76taigv/bafkreias6wln3tfsbibp2sb3dkwug3ftmu4guux54r7nkvvuclyv4dam7q@jpeg)
March 20, 2025 at 12:14 AM
One never knows where research can take you. Behold, the work (performed at NIH in 1982) that led to Ozempic/Wegovy. DOGE would prob kill this-- why would anyone care about Gila monster venom or guinea pig pancreases? Well, about 15 million Americans. How many future cures are being killed, now?
And, kind of an amazing paragraph:
March 14, 2025 at 10:12 PM
And, kind of an amazing paragraph:
Doing a little research and came across some amazing drawings to share.
March 14, 2025 at 9:45 PM
Doing a little research and came across some amazing drawings to share.
The stove is hot. You’ve touched it before. The burn was so, so painful. I mean, why would anyone choose to touch the stove, again? That would be silly— we know what will happen. Meanwhile, Republicans (including many who absolutely know better)..
February 12, 2025 at 6:54 PM
The stove is hot. You’ve touched it before. The burn was so, so painful. I mean, why would anyone choose to touch the stove, again? That would be silly— we know what will happen. Meanwhile, Republicans (including many who absolutely know better)..
The US does not have an offensive bioweapons program. Gain of function research did not lead to SARS-CoV-2. The scientific evidence points to a NATURAL zoonosis, ie a jump from infected animals to people. If there is evidence to the contrary it has not been presented.
February 2, 2025 at 9:32 PM
The US does not have an offensive bioweapons program. Gain of function research did not lead to SARS-CoV-2. The scientific evidence points to a NATURAL zoonosis, ie a jump from infected animals to people. If there is evidence to the contrary it has not been presented.
