In analyses led by @ZabehErfan, we also show that neural dynamics under cholinergic blockade can be decoded from low-dimensional features of LFPs across electrodes.
May 14, 2025 at 2:55 PM
In analyses led by @ZabehErfan, we also show that neural dynamics under cholinergic blockade can be decoded from low-dimensional features of LFPs across electrodes.
When scopolamine was present at encoding, patients had selective recollection deficits and disrupted hippocampal theta.
But when the drug was present only at retrieval, memory was spared—even though theta power, phase reset, and reinstatement were disrupted.
But when the drug was present only at retrieval, memory was spared—even though theta power, phase reset, and reinstatement were disrupted.
May 14, 2025 at 2:55 PM
When scopolamine was present at encoding, patients had selective recollection deficits and disrupted hippocampal theta.
But when the drug was present only at retrieval, memory was spared—even though theta power, phase reset, and reinstatement were disrupted.
But when the drug was present only at retrieval, memory was spared—even though theta power, phase reset, and reinstatement were disrupted.
We gave scopolamine (a muscarinic cholinergic blocker) to epilepsy patients with implanted hippocampal electrodes as they performed a memory task.
By injecting the drug before retrieval vs. before encoding we could tease apart the role of theta oscillations at each memory stage.
By injecting the drug before retrieval vs. before encoding we could tease apart the role of theta oscillations at each memory stage.
May 14, 2025 at 2:55 PM
We gave scopolamine (a muscarinic cholinergic blocker) to epilepsy patients with implanted hippocampal electrodes as they performed a memory task.
By injecting the drug before retrieval vs. before encoding we could tease apart the role of theta oscillations at each memory stage.
By injecting the drug before retrieval vs. before encoding we could tease apart the role of theta oscillations at each memory stage.