Excellent new review on predicting response to the low FODMAP diet. Symptom severity, breath tests + microbiota all explored - but clinical & psychological factors are the most practical right now. Next step: simple validated tools to personalise treatment.

pubmed.ncbi.nlm.nih.gov/40419398/

Coeliac disease is increasing worldwide, shaped by HLA genetics and uncertain environmental factors. Most remain undiagnosed beneath the “Coeliac Iceberg". This paper highlights the need for proactive population screening over case-finding.

www.sciencedirect.com/science/arti...

Immunology in Coeliac Disease.

T cells, APCs, B & epithelial cells drive CeD. The Exact immunologic sequence is unknown. HLA-DQ2 & DQ8 are essential. Without DQ2 and DQ8, CeD is (mostly) ruled out.

www.sciencedirect.com/science/arti...

Dietary legumes and the gut microbiome: a comprehensive review

🫘 Mixed effects on the microbiome

🫛 some studies showed ↑ diversity, others none.

🫘 Consistently ↑ beneficial species like Bifidobacterium & Faecalibacterium.

More standardized, long-term studies needed.

doi.org/10.1080/1040...

New meta-analysis identifies accidental gluten exposure as primary cause of non-responsive coeliac disease. Underscores urgent need for improved support & greater access to specialist coeliac services for pts with persistent symptoms.

📄 onlinelibrary.wiley.com/doi/full/10....

Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis:

- Aprox 16% of CeD is ? PCD
- 1/3 progress to CeD with gluten
- Many normalise serology
- Symptomatic PCD - GFD = 🥳
- More research needed

#CoeliacDisease

📄 gut.bmj.com/content/gutj...

AOECS highlights the challenges of Gluten-Free Beer Testing.

🍺 Tests are evolving.
🍺 Beers <20 ppm - Safe.
🍺 Calls for clinical trials.
🍺 Trust the GF Symbol!

#Coeliac #GlutenFreeBeer

www.aoecs.org/news/aoecs-p...

Gluten Unraveled: Latest Insights on Terminology, Diagnosis, Pathophysiology, Dietary Strategies, & Intestinal Microbiota Modulations.

📃 www.mdpi.com/2072-6643/16...