Gareth Ball
@garedaba.bsky.social
Neurodevelopmental Modelling @ MCRI in Melbourne. Early brain development, neuroscience, ML.
Reposted by Gareth Ball
On Friday/Saturday I have a poster (1205) on our work using generative network models, where I explore how heterochronous spatial gradients constrain brain connectivty 🧠⌛🏳️🌈 Also Saturday (11:30am; Great Hall) I have a talk on this work, so make sure you have recovered from club night in time for it!
June 25, 2025 at 3:13 AM
On Friday/Saturday I have a poster (1205) on our work using generative network models, where I explore how heterochronous spatial gradients constrain brain connectivty 🧠⌛🏳️🌈 Also Saturday (11:30am; Great Hall) I have a talk on this work, so make sure you have recovered from club night in time for it!
We also demonstrate some intriguing findings on the enrichment of hub genes in human-accelerated genomic regions, associations with adult brain phenotypes and links to neurodevelopmental disorders.
more details here: www.biorxiv.org/content/10.1...
more details here: www.biorxiv.org/content/10.1...
Transcriptomic divergence of network hubs in the prenatal human brain
Connections in the human brain are not uniformly distributed; instead, a dense network of long-range projections converge on highly connected hub regions located in transmodal, paralimbic, and associa...
www.biorxiv.org
May 28, 2025 at 5:17 AM
We also demonstrate some intriguing findings on the enrichment of hub genes in human-accelerated genomic regions, associations with adult brain phenotypes and links to neurodevelopmental disorders.
more details here: www.biorxiv.org/content/10.1...
more details here: www.biorxiv.org/content/10.1...
We think this shows that hub regions begin forming circuits earlier than non-hub regions, affording more time to form the structural foundations of the brain's network.
a woman is talking on a phone and the words i 'm networking are above her
ALT: a woman is talking on a phone and the words i 'm networking are above her
media.tenor.com
May 28, 2025 at 5:17 AM
We think this shows that hub regions begin forming circuits earlier than non-hub regions, affording more time to form the structural foundations of the brain's network.
Hub genes were specifically enriched for subplate neurons, the earliest population of neurons to mature and cirtical for the correct targeting of neural connections, as well as deep layer cortical neurons that connect across cortical areas.
May 28, 2025 at 5:17 AM
Hub genes were specifically enriched for subplate neurons, the earliest population of neurons to mature and cirtical for the correct targeting of neural connections, as well as deep layer cortical neurons that connect across cortical areas.
We found that, by 20 weeks gestation, future cortical hubs can be identified by increased expression of genes associated with the formation and assembly of neural circuits in the subplate
May 28, 2025 at 5:17 AM
We found that, by 20 weeks gestation, future cortical hubs can be identified by increased expression of genes associated with the formation and assembly of neural circuits in the subplate
While core hub connections are formed prior to the time of birth, the mechanism by which they arise are unclear.
We used our recent digital atlas - microBrain - to compare gene expression in cortical areas of the prenatal brain that go on to form network hubs
www.nature.com/articles/s41...
We used our recent digital atlas - microBrain - to compare gene expression in cortical areas of the prenatal brain that go on to form network hubs
www.nature.com/articles/s41...
May 28, 2025 at 5:17 AM
While core hub connections are formed prior to the time of birth, the mechanism by which they arise are unclear.
We used our recent digital atlas - microBrain - to compare gene expression in cortical areas of the prenatal brain that go on to form network hubs
www.nature.com/articles/s41...
We used our recent digital atlas - microBrain - to compare gene expression in cortical areas of the prenatal brain that go on to form network hubs
www.nature.com/articles/s41...