📄 Link to paper: rdcu.be/eL8mR

🧵Link to a long thread: bsky.app/profile/gang...

#Microbiome #FMT #cdiff #IBD #PrecisionMedicine #NatureMicrobiology #MountSinai #FecalMicrobiotaTransplantation #Gastroenterology #MicrobiotaTherapeutics n/ END

👏 Congrats to first author
@yufan01.bsky.social, with nearly 5-year effort and innovation, thanks to *Jeremiah Faith*, our wonderful collaborator, @fannimi2001.bsky.social, @magdalenaksi.bsky.social and the entire team! @sinaigenetics.bsky.social @sinaiimmuno.bsky.social @mountsinaigi.bsky.social 5/

We’re excited because this study has important implications on the design of defined bacterial cocktails that are safer, more effective, more robust, and more consistent than whole-stool FMT. 4/

separating very similar strains that coexist in donors' or patients' gut. Our approach—building on long-read DNA sequencing—can tell highly similar strains apart, and importantly, detect their genomic changes that may reflect how bacteria 🦠 adapt to patients' gut after transplantation. 3/

We developed a precise way to track which donor bacteria successfully colonize after FMT and how they change over time—by identifying a unique genetic “fingerprint” in each bacterial strain. Previous studies have yielded great insights into FMT, but faced challenges 2/

ELGG paper has the following the statement about Bifidobacterium bifidum MAGs: "For instance, the MAGs from B. bifidum contain 27 CAZy families, 10 of which were not found in reference isolate genomes ... GH3, GH5, GH9, GH43, GH127, GH38, CE10, GH8, CBM6, and GH94"
www.nature.com/articles/s41...