Recent publication from a great collaboration with my friends in Cuernavaca, México: The Smarce1 subunit of the BAF complex performs distinct, stage-specific functions during zebrafish retinal development doi.org/10.1016/j.ne.... Support @ibroorg.bsky.social, publish in @ibrojournals.bsky.social

A reduction in apical/basal tension, on the other hand, would produce extensive cell extrusion after a period of relative stability. When extrapolated to a living tissue, these observations could be explained by cell-cell and cell-matrix adhesion, relying on F-actin-generated tension across cells.

Making a long story short, and skipping the quantitative part (if interested, ask Santi), what we found is that the relatively crowded simulated pseudostratified epithelium was stable as long as apical/basal tension was kept high relative to lateral tension. An example is reproduced in the video.

Here is where theoretical modelling enters the story. The goal was to simulate a pseudostratified epithelium using an energy-based 2D vertex model to get cells with flexible borders, able to respond to the changing positions of non-deformable nuclei. The "fake neuroepithelium" is seen from a side.

Apical cell extrusion could be due either to an induction of cell death, folowed by expulsion, or by live cell extrusion, a response to epithelial overcrowding. The experiments in the present report indicate the latter to be responsible for PMA effect, hence: mechanical forces must be involved!

The Virtual Special Issue of Neuroscience celebrating the 30th anniversary of @socneurouy.bsky.social is completed, and with a cover! Find it and read it in full here: sciencedirect.com/special-issu...
@ibroorg.bsky.social @ibrojournals.bsky.social

El próximo viernes 25 de julio, a las 10 AM, en el Salón de Seminarios 1, de Facultad de Ciencias, Gonzalo Aparicio hará la defensa pública de su Tesis de Doctorado (PEDECIBA Biología). Los esperamos!

Happy to share the last article of the Virtual Special Issue of Neuroscience @ibrojournals.bsky.social devoted to the 30th anniversary of @socneurouy.bsky.social: the editorial! Coauthorship shared with Ana Silva and Nathalia Vitureira. authors.elsevier.com/a/1lL%7Eq_6z...
@ibroorg.bsky.social

Great part of our lab last year, around this time.... Amazing! By the way ... Enjoy the shower, if you can!

It is with great joy that we are receiving @valetornini.bsky.social these weeks, who came to the land of her ancestors for scientific networking. Looking forward to her talk tomorrow at Facultad de Ciencias, Udelar. Will she dare to give her talk in Spanish? Yes, she will! @socneurouy.bsky.social

Another one! Mitochondria and astrocyte reactivity: Key mechanism behind neuronal injury. By P. Cassina, @ernestomiquel.bsky.social, L. Martínez-Palma, A. Cassina. From @histoemb.bsky.social doi.org/10.1016/j.ne...

New addition: The Trail of axonal protein Synthesis: Origins and current functional Landscapes. @joagarat.bsky.social, A Di Paolo, G Eastman, PE Castillo, J Sotelo-Silveira
IIBCE
doi.org/10.1016/j.ne...

The second one, by E Isasi and S Olivera-Bravo, also from IIBCE, focuses in the role of iron deficiency on the impairment of neurovasculature: doi.org/10.1016/j.ne...

The first one, written by C Echeverry, M Pazos, M Torres-Pérez and G Prunell, from IIBCE, analyzes the potential of plant-derived compounds for the treatment of neurodegenerative diseases: doi.org/10.1016/j.ne...

@socneurouy.bsky.social turned 30 yo in 2024, and we celebrated in different ways. One was the organization of a Special Issue dedicated to neuroscience in Uruguay, in Neuroscience @ibrojournals.bsky.social. The first two articles are already available here: sciencedirect.com/journal/neur...

Since I could not attach an ALT text to the time-lapse video, it goes here:

So, what do we do at the CBND? This 20-yo video summarizes a lot of it, all around neuroepithelial cell polarity and its transition to neuronal polarity, largely on the retina, but also looking at morphogenetic processes like neurulation. Mostly on zebrafish, a bit on chick. Look at the ALT text!

Being new to this network, a presentation is in order. This will eventually become a thread. I first want to acknowledge these guys, the members of the Cell Biology of Neural Development group, of which I am privileged to be the current PI. #neurodevelopment #retina #neurulation #zebrafish #chick