The Fromm Lab
@frommlab.bsky.social
lab at @UiTNorgesarktis studying microRNAs, paleotranscriptomics, biosystematics with a fable for flatworms.
MirGeneDB, MirMachine, MirMiner (soon!)
MirGeneDB, MirMachine, MirMiner (soon!)
Super happy to host @lovedalen.bsky.social today talking about deep time genomics!
October 21, 2025 at 8:35 AM
Super happy to host @lovedalen.bsky.social today talking about deep time genomics!
Having a great time at the Friedrich Löffler Institute in Greifswald. Impressive place (850 people work here). Many exciting questions about (viral) microRNAs after my presentation. Thank you for the invitation to Balal Sadeghi!!!
September 17, 2025 at 8:03 AM
Having a great time at the Friedrich Löffler Institute in Greifswald. Impressive place (850 people work here). Many exciting questions about (viral) microRNAs after my presentation. Thank you for the invitation to Balal Sadeghi!!!
#argonautes2025 end (for me) with an amazing dinner. Thank you for organizing @svobodalab.bsky.social
August 29, 2025 at 8:22 PM
#argonautes2025 end (for me) with an amazing dinner. Thank you for organizing @svobodalab.bsky.social
#argonautes2025 day3 with amazing talks spanning widely over generegulation to evolution and parasitic interaction (via AGO).
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
August 29, 2025 at 2:20 PM
#argonautes2025 day3 with amazing talks spanning widely over generegulation to evolution and parasitic interaction (via AGO).
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
A presentation by the Argonautes Syndrom family alliance reminded how relevant research on Argonautes and related mechanisms is
#argonautes2025
What to say: RNA U come around
What to say: RNA U come around
August 28, 2025 at 8:30 PM
#argonautes2025
What to say: RNA U come around
What to say: RNA U come around
#argonautes2025 day 2 started strong 💪🏻
August 28, 2025 at 12:17 PM
#argonautes2025 day 2 started strong 💪🏻
#argonautes 2025 starts with a card game including 4 Jokers (Nobellaureates)
August 27, 2025 at 3:20 PM
#argonautes 2025 starts with a card game including 4 Jokers (Nobellaureates)
What a beautiful trip!! Thank you @enricodanielloszn.bsky.social
July 16, 2025 at 5:35 AM
What a beautiful trip!! Thank you @enricodanielloszn.bsky.social
SedaDNA2025 is Go!
@arcecogen.bsky.social
@arcecogen.bsky.social
June 24, 2025 at 7:24 AM
SedaDNA2025 is Go!
@arcecogen.bsky.social
@arcecogen.bsky.social
8/9 🔁 These results echo my 2013 study in MBE @official-smbe.bsky.social
Parasitic flatworms also show massive microRNA losses (up to ~50%)
→ Suggesting a general principle in lophotrochozoan parasite evolution:
💥 Regulatory gene loss accompanies simplification.
pubmed.ncbi.nlm.nih.gov/24025793/
Parasitic flatworms also show massive microRNA losses (up to ~50%)
→ Suggesting a general principle in lophotrochozoan parasite evolution:
💥 Regulatory gene loss accompanies simplification.
pubmed.ncbi.nlm.nih.gov/24025793/
June 23, 2025 at 1:51 PM
8/9 🔁 These results echo my 2013 study in MBE @official-smbe.bsky.social
Parasitic flatworms also show massive microRNA losses (up to ~50%)
→ Suggesting a general principle in lophotrochozoan parasite evolution:
💥 Regulatory gene loss accompanies simplification.
pubmed.ncbi.nlm.nih.gov/24025793/
Parasitic flatworms also show massive microRNA losses (up to ~50%)
→ Suggesting a general principle in lophotrochozoan parasite evolution:
💥 Regulatory gene loss accompanies simplification.
pubmed.ncbi.nlm.nih.gov/24025793/
6/9 Regression in proteins and microRNAs is mirrored by morphology!
Losses:
▪️Digestive tract
▪️Ciliated head structures
▪️Protonephridia
And just like gene losses, morphological losses track with microRNA and BUSCO reductions.
Parasitism = evolutionary pruning. 🪓
However, new features evolve, too!
Losses:
▪️Digestive tract
▪️Ciliated head structures
▪️Protonephridia
And just like gene losses, morphological losses track with microRNA and BUSCO reductions.
Parasitism = evolutionary pruning. 🪓
However, new features evolve, too!
June 23, 2025 at 1:51 PM
6/9 Regression in proteins and microRNAs is mirrored by morphology!
Losses:
▪️Digestive tract
▪️Ciliated head structures
▪️Protonephridia
And just like gene losses, morphological losses track with microRNA and BUSCO reductions.
Parasitism = evolutionary pruning. 🪓
However, new features evolve, too!
Losses:
▪️Digestive tract
▪️Ciliated head structures
▪️Protonephridia
And just like gene losses, morphological losses track with microRNA and BUSCO reductions.
Parasitism = evolutionary pruning. 🪓
However, new features evolve, too!
5/9 🔍 The 280 lost core genes in parasitic lineages are not random.
They're enriched for regulatory functions:
⚙️ Transcription factors
⚙️ RNA Pol II complex components
⚙️ Translation regulators
→ Suggests regulatory collapse as parasitism advances.
They're enriched for regulatory functions:
⚙️ Transcription factors
⚙️ RNA Pol II complex components
⚙️ Translation regulators
→ Suggests regulatory collapse as parasitism advances.
June 23, 2025 at 1:51 PM
5/9 🔍 The 280 lost core genes in parasitic lineages are not random.
They're enriched for regulatory functions:
⚙️ Transcription factors
⚙️ RNA Pol II complex components
⚙️ Translation regulators
→ Suggests regulatory collapse as parasitism advances.
They're enriched for regulatory functions:
⚙️ Transcription factors
⚙️ RNA Pol II complex components
⚙️ Translation regulators
→ Suggests regulatory collapse as parasitism advances.
4/9
📉 Curiously we find that microRNA loss correlates with other forms of genome simplification.
🔸 Each lost microRNA family ≈ 400 protein-coding genes lost
🔸 Strong correlation with metazoan core gene loss (BUSCO)
🔸 Not explained by genome assembly quality or size
Simplification at every level.
📉 Curiously we find that microRNA loss correlates with other forms of genome simplification.
🔸 Each lost microRNA family ≈ 400 protein-coding genes lost
🔸 Strong correlation with metazoan core gene loss (BUSCO)
🔸 Not explained by genome assembly quality or size
Simplification at every level.
June 23, 2025 at 1:51 PM
4/9
📉 Curiously we find that microRNA loss correlates with other forms of genome simplification.
🔸 Each lost microRNA family ≈ 400 protein-coding genes lost
🔸 Strong correlation with metazoan core gene loss (BUSCO)
🔸 Not explained by genome assembly quality or size
Simplification at every level.
📉 Curiously we find that microRNA loss correlates with other forms of genome simplification.
🔸 Each lost microRNA family ≈ 400 protein-coding genes lost
🔸 Strong correlation with metazoan core gene loss (BUSCO)
🔸 Not explained by genome assembly quality or size
Simplification at every level.
3/9
🧬 Figure 1: microRNA losses across Syndermata
🔹Free-living rotifers (Monogononta, Bdelloidea): mild miRNA loss
🔹Seisonidea: ~67% loss
🔹Acanthocephala: a shocking 85% microRNA family loss
This is the most extreme microRNA reduction ever reported in bilaterians.
📉🧫
🧬 Figure 1: microRNA losses across Syndermata
🔹Free-living rotifers (Monogononta, Bdelloidea): mild miRNA loss
🔹Seisonidea: ~67% loss
🔹Acanthocephala: a shocking 85% microRNA family loss
This is the most extreme microRNA reduction ever reported in bilaterians.
📉🧫
June 23, 2025 at 1:51 PM
3/9
🧬 Figure 1: microRNA losses across Syndermata
🔹Free-living rotifers (Monogononta, Bdelloidea): mild miRNA loss
🔹Seisonidea: ~67% loss
🔹Acanthocephala: a shocking 85% microRNA family loss
This is the most extreme microRNA reduction ever reported in bilaterians.
📉🧫
🧬 Figure 1: microRNA losses across Syndermata
🔹Free-living rotifers (Monogononta, Bdelloidea): mild miRNA loss
🔹Seisonidea: ~67% loss
🔹Acanthocephala: a shocking 85% microRNA family loss
This is the most extreme microRNA reduction ever reported in bilaterians.
📉🧫
Beautiful discovery right at the beach.
June 21, 2025 at 9:00 PM
Beautiful discovery right at the beach.
Very nice seminar by sabbatical guest @pedromartinezserra.bsky.social on the amazing Symsagittifera acoels!
March 28, 2025 at 12:29 PM
Very nice seminar by sabbatical guest @pedromartinezserra.bsky.social on the amazing Symsagittifera acoels!
Very successful collection session with @pedromartinezserra.bsky.social
February 6, 2025 at 6:04 AM
Very successful collection session with @pedromartinezserra.bsky.social
And the sun is back!!!!
January 22, 2025 at 10:23 AM
And the sun is back!!!!
January 13, 2025 at 10:54 AM
Happy New Year! (Also happy to have deleted X now)
January 2, 2025 at 7:56 PM
Happy New Year! (Also happy to have deleted X now)
Nice!!! Got one in my office
December 19, 2024 at 11:43 AM
Nice!!! Got one in my office
Very happy about today's course "microRNA annotation and expression analysis" we gave under the Bioinformatics week in Oslo! Thank you for the invitation and participation and Eirik and Alessandro for help1
December 13, 2024 at 7:05 PM
Very happy about today's course "microRNA annotation and expression analysis" we gave under the Bioinformatics week in Oslo! Thank you for the invitation and participation and Eirik and Alessandro for help1
