@fredbarras.bsky.social
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
June 26, 2025 at 6:56 PM
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
![Overall architecture of the SmsC2B2 complex. Top left: AMP-PNP-loaded SmsC2B2 crystal structure. Top right: Close-up on the binding site of the AMP-PNP/Mg2+ showing residues surrounding the binding site of AMP-PNP. Bottom left: Cryo-EM structure of the [Fe-S]-bound SmsC2B2 complex. Bottom right: Close-up on the binding site of the [Fe-S] cluster showing the C218, C239, and C242 coordinating the [Fe-S] cluster. The cluster binding site lies in a solvent-exposed hydrophobic pocket consisting of residues P40, L216, I223, Y235, F234, and P247.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5522ztebtekoor5efelihqhb/bafkreigq7fsftcqadfcu2msy5pmyxf6fgce3eelb6fe7xrijsvazsc64va@jpeg)
June 26, 2025 at 5:07 PM
Reposted
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
June 26, 2025 at 4:38 PM
The minimal #IronSulfurCluster [Fe-S] biogenesis systems MIS & SMS are ancestral to modern ones. This study shows that the ancestral SMS system from M. jannaschii assembles [Fe-S] clusters via unique ATP-regulated mechanisms & uses sulfide as a #sulfur source @plosbiology.org 🧪 plos.io/46l0BoC
