Frances Arnold
@francesarnold.bsky.social
Engineer/scientist, Nobel Prize in Chemistry 2018
I love evolution, enzymes, protein engineering, AI
Linus Pauling Professor at Caltech
I love evolution, enzymes, protein engineering, AI
Linus Pauling Professor at Caltech
Friday night at Adams pack station. 9 miles and a century from @caltech.
October 19, 2025 at 3:22 PM
Friday night at Adams pack station. 9 miles and a century from @caltech.
Reposted by Frances Arnold
A new round of layoffs at Nasa’s jet propulsion lab will result in ‘an untold loss of scientific knowledge and expertise’ according to congresswoman Judy Chu.
Nasa’s Jet Propulsion Lab and home of Mars rovers loses 10% of its staff
The dismissal of 550 JPL workers is the fourth round of recent layoffs at the lab, prompting fears of a brain drain
www.chemistryworld.com
October 19, 2025 at 2:33 PM
A new round of layoffs at Nasa’s jet propulsion lab will result in ‘an untold loss of scientific knowledge and expertise’ according to congresswoman Judy Chu.
Looking for PhD or postdoctoral opportunities in #AI+biology #proteinengineering? the brilliant @arianemora.bsky.social has joined @aithyra.bsky.social in beautiful #vienna. I wish I could start over again!
Welcome ARIANE MORA!
With great pleasure we announce that Ariane Mora is one of the Starting Principal Investigators AI/LS who will join AITHYRA in November 2025. Ariane combines molecular biology, AI, and software engineering. More information: www.oeaw.ac.at/aithyra/rese...
#AITHYRA #StartingPI
With great pleasure we announce that Ariane Mora is one of the Starting Principal Investigators AI/LS who will join AITHYRA in November 2025. Ariane combines molecular biology, AI, and software engineering. More information: www.oeaw.ac.at/aithyra/rese...
#AITHYRA #StartingPI
September 8, 2025 at 5:30 AM
Looking for PhD or postdoctoral opportunities in #AI+biology #proteinengineering? the brilliant @arianemora.bsky.social has joined @aithyra.bsky.social in beautiful #vienna. I wish I could start over again!
Our new paper on AI-generated TrpBs with @anima-anandkumar.bsky.social. GenSLM generated very useful promiscuous TrpB #enzymes, bypassing a lot of #directedevolution! great work by the whole team, especially Theophile Lambert. www.biorxiv.org/content/10.1...
www.biorxiv.org
September 4, 2025 at 2:58 PM
Our new paper on AI-generated TrpBs with @anima-anandkumar.bsky.social. GenSLM generated very useful promiscuous TrpB #enzymes, bypassing a lot of #directedevolution! great work by the whole team, especially Theophile Lambert. www.biorxiv.org/content/10.1...
Reposted by Frances Arnold
A compelling review of how ML/AI could help in the quest to find an enzyme for every reaction.
@jsunn-y.bsky.social @francescazfl.bsky.social Yueming Long @francesarnold.bsky.social
www.cell.com/cell-systems...
@jsunn-y.bsky.social @francescazfl.bsky.social Yueming Long @francesarnold.bsky.social
www.cell.com/cell-systems...
September 3, 2025 at 12:47 PM
A compelling review of how ML/AI could help in the quest to find an enzyme for every reaction.
@jsunn-y.bsky.social @francescazfl.bsky.social Yueming Long @francesarnold.bsky.social
www.cell.com/cell-systems...
@jsunn-y.bsky.social @francescazfl.bsky.social Yueming Long @francesarnold.bsky.social
www.cell.com/cell-systems...
Private tour of the Louvre is a special treat. They were vacuuming the Sphinx. You may not have seen a Sphinx being brushed, so I am sharing.
September 3, 2025 at 8:36 AM
Private tour of the Louvre is a special treat. They were vacuuming the Sphinx. You may not have seen a Sphinx being brushed, so I am sharing.
On the beautiful @Caltech campus with two new professors @reisenbauerlab.bsky.social and @arianemora.bsky.social headed to start their careers in Vienna. Prospective graduate students take note! This is the future of #enzymes #proteinengineering. @caltechcce.bsky.social @caltech.edu
August 10, 2025 at 7:14 PM
On the beautiful @Caltech campus with two new professors @reisenbauerlab.bsky.social and @arianemora.bsky.social headed to start their careers in Vienna. Prospective graduate students take note! This is the future of #enzymes #proteinengineering. @caltechcce.bsky.social @caltech.edu
Loved seeing so many former #Arnoldgroup members at GRC #ProteinEngineering this week! Protein engineering is in good hands.
July 31, 2025 at 2:57 PM
Loved seeing so many former #Arnoldgroup members at GRC #ProteinEngineering this week! Protein engineering is in good hands.
I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes
Azaspiro[2.y]alkanes are increasingly valuable scaffolds in pharmaceutical drug discovery; however, an asymmetric catalytic method for their synthesis remains unknown. Here, we present a stereodiverge...
pubs.acs.org
July 22, 2025 at 7:29 PM
I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
I saw it firsthand at the Lindau Nobel Laureates meeting--international young scientists welcomed and recruited in Germany and elsewhere.
www.wsj.com/politics/pol...
www.wsj.com/politics/pol...
America’s Brain Drain Could Become the World’s Brain Gain
Research-funding cuts and immigration changes threaten some of America’s economic advantages.
www.wsj.com
July 12, 2025 at 12:19 PM
I saw it firsthand at the Lindau Nobel Laureates meeting--international young scientists welcomed and recruited in Germany and elsewhere.
www.wsj.com/politics/pol...
www.wsj.com/politics/pol...
Reposted by Frances Arnold
📅July 7-11
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
July 2, 2025 at 8:14 AM
📅July 7-11
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
The 2025 Onassis Lectures in Biology and Chemistry will be held @forth-ite.bsky.social, Heraklion, Crete. This year’s Lectures are devoted to the advances, challenges, and future prospects of #Re-engineeringBiology through #DirectedEvolution and #Synthetic cellular pathways.
Reposted by Frances Arnold
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
Research Position (PhD) in organic chemistry and b...
<div style="text-align: justify;">The research group „Organic Chemistry and&nb...
uni-bielefeld.hr4you.org
June 27, 2025 at 9:13 PM
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
Really enjoying #Repartzymes Repurposed and Artificial Enzymes meeting organized by #TomWard of Uni. Basel. Many former group members are here! rep.artzymes.info
June 27, 2025 at 12:25 PM
Really enjoying #Repartzymes Repurposed and Artificial Enzymes meeting organized by #TomWard of Uni. Basel. Many former group members are here! rep.artzymes.info
I'm honored to be involved in the SDSS @stanforddoerr.bsky.social --we need it now more than ever. Let's continue to be bold about building the future.
Join us in welcoming @francesarnold.bsky.social to the @stanforddoerr.bsky.social Advisory Council. As the @caltech.edu Linus Pauling Professor and a Nobel Laureate in Chemistry, she will make important contributions to the school’s bold ambition of building a more sustainable future for all.
June 25, 2025 at 8:36 PM
I'm honored to be involved in the SDSS @stanforddoerr.bsky.social --we need it now more than ever. Let's continue to be bold about building the future.
Reposted by Frances Arnold
Steered generation for protein optimization: On datasets with ~10^2 measurements, steering a discrete diffusion model outperforms RL on a protein language model for generating improved variants.
@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social
arxiv.org/abs/2505.15093
@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social
arxiv.org/abs/2505.15093
May 22, 2025 at 6:33 PM
Steered generation for protein optimization: On datasets with ~10^2 measurements, steering a discrete diffusion model outperforms RL on a protein language model for generating improved variants.
@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social
arxiv.org/abs/2505.15093
@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social
arxiv.org/abs/2505.15093
Took a walk in the woods this weekend. So good for the soul.
March 30, 2025 at 3:38 PM
Took a walk in the woods this weekend. So good for the soul.
Such a pleasure to gather with current and former Arnold group members in San Diego! Thank you one and all. #ACSSpring2025
March 27, 2025 at 12:48 PM
Such a pleasure to gather with current and former Arnold group members in San Diego! Thank you one and all. #ACSSpring2025
I got to tell some stories I don't usually include in science talks. Thank you for coming. I will post the address on my website soon.
An amazing, totally inspirational and emotional journey! The @acs.org Priestley Medal talk by @francesarnold.bsky.social at #ACSSpring2025
March 25, 2025 at 2:24 PM
I got to tell some stories I don't usually include in science talks. Thank you for coming. I will post the address on my website soon.
Reposted by Frances Arnold
Before you meet @francesarnold.bsky.social at #ACSSpring2025, read my profile of her in @cenmag.bsky.social
cen.acs.org/people/award...
cen.acs.org/people/award...
March 21, 2025 at 3:45 PM
Before you meet @francesarnold.bsky.social at #ACSSpring2025, read my profile of her in @cenmag.bsky.social
cen.acs.org/people/award...
cen.acs.org/people/award...
Reposted by Frances Arnold
Meet @francesarnold.bsky.social, 2025 Priestley Medalist, at #ACSSpring2025.
Stop by the ACS Booth Theater in the Expo Hall to hear about her contributions to #chemistry and pick up a signed copy of her C&EN feature issue.
RSVP: connect.discoveracs.org/cen-priestle... #chemsky
Stop by the ACS Booth Theater in the Expo Hall to hear about her contributions to #chemistry and pick up a signed copy of her C&EN feature issue.
RSVP: connect.discoveracs.org/cen-priestle... #chemsky
March 13, 2025 at 10:56 AM
Meet @francesarnold.bsky.social, 2025 Priestley Medalist, at #ACSSpring2025.
Stop by the ACS Booth Theater in the Expo Hall to hear about her contributions to #chemistry and pick up a signed copy of her C&EN feature issue.
RSVP: connect.discoveracs.org/cen-priestle... #chemsky
Stop by the ACS Booth Theater in the Expo Hall to hear about her contributions to #chemistry and pick up a signed copy of her C&EN feature issue.
RSVP: connect.discoveracs.org/cen-priestle... #chemsky
Reposted by Frances Arnold
Also remember that the National Archives maintains prior administrations' websites, e.g., bidenwhitehouse.archives.gov. I spent a lot of time unnecessarily downloading the Obama-era OSTP archive in 2017.
January 20, 2025 at 11:01 PM
Also remember that the National Archives maintains prior administrations' websites, e.g., bidenwhitehouse.archives.gov. I spent a lot of time unnecessarily downloading the Obama-era OSTP archive in 2017.
The White House website has been wiped clean, but thanks to @erichorvitz.bsky.social , all the Biden #PCAST reports are available below. I want to thank the #PCAST members, all of whom donated their time and expertise to helping policy be science-based. tinyurl.com/2acnv2nh
PCAST Reports (2020-2025)
tinyurl.com
January 20, 2025 at 10:53 PM
The White House website has been wiped clean, but thanks to @erichorvitz.bsky.social , all the Biden #PCAST reports are available below. I want to thank the #PCAST members, all of whom donated their time and expertise to helping policy be science-based. tinyurl.com/2acnv2nh
Reposted by Frances Arnold
Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in @naturecomms.bsky.social!
Paper: www.nature.com/articles/s41...
Check out the original thread here: x.com/jsunn_y/stat...
Paper: www.nature.com/articles/s41...
Check out the original thread here: x.com/jsunn_y/stat...
x.com
x.com
January 16, 2025 at 6:04 PM
Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in @naturecomms.bsky.social!
Paper: www.nature.com/articles/s41...
Check out the original thread here: x.com/jsunn_y/stat...
Paper: www.nature.com/articles/s41...
Check out the original thread here: x.com/jsunn_y/stat...
Hell continues in #LosAngeles with the #LAfires. I live next to #Altadena, which is pretty much destroyed. My power finally came on after three cold nights. So many have lost their homes, and danger not over since big winds are coming back starting tomorrow. Views at my house Wednesday early am.
January 12, 2025 at 5:37 PM
Hell continues in #LosAngeles with the #LAfires. I live next to #Altadena, which is pretty much destroyed. My power finally came on after three cold nights. So many have lost their homes, and danger not over since big winds are coming back starting tomorrow. Views at my house Wednesday early am.