FOR5596 - SAM-dependent enzyme chemistry
@for5596.bsky.social
"Unfolding the potential of SAM-dependent enzyme chemistry"
Research group funded by the DFG
https://for5596.uni-freiburg.de/
Research group funded by the DFG
https://for5596.uni-freiburg.de/
Our new J. Nat. Prod. study is out! Discover how the enzyme NapB5 achieves precise dual C-methylation and expands natural-product diversity across Actinomycetes.
Congratulation to all authors from FOR5596! @andexerlab.bsky.social
Congratulation to all authors from FOR5596! @andexerlab.bsky.social
In Vitro Characterization of the Aromatic SAM-Dependent C-Methyltransferase NapB5
Aromatic polyketide synthase (PKS) products undergo diverse tailoring reactions in the biosynthesis of natural products. S-Adenosyl-l-methionine (SAM)-dependent C-methyltransferases (C-MTs) play a key...
pubs.acs.org
November 17, 2025 at 9:23 AM
Our new J. Nat. Prod. study is out! Discover how the enzyme NapB5 achieves precise dual C-methylation and expands natural-product diversity across Actinomycetes.
Congratulation to all authors from FOR5596! @andexerlab.bsky.social
Congratulation to all authors from FOR5596! @andexerlab.bsky.social
Late greetings from the Science Days at Europa-Park! We are impressed by all the motivated school kids interested in STEM! Thank you to all our team members for your help!
November 4, 2025 at 1:03 PM
Late greetings from the Science Days at Europa-Park! We are impressed by all the motivated school kids interested in STEM! Thank you to all our team members for your help!
We are preparing for the Science Days at Europa-Park (23.-25.10.25). We are encouraging pupils to pursue STEM!
October 22, 2025 at 2:51 PM
We are preparing for the Science Days at Europa-Park (23.-25.10.25). We are encouraging pupils to pursue STEM!
Greetings from all of our members at the three-day annual meeting in St. Peter in 2025. Thank you for a successfull year filled with hard work, collaboration, great ideas and a lot of motivation for our future research.
October 14, 2025 at 11:39 AM
Greetings from all of our members at the three-day annual meeting in St. Peter in 2025. Thank you for a successfull year filled with hard work, collaboration, great ideas and a lot of motivation for our future research.
We are organizing a session on SAM-dependent enzymes at the 38th Irsee Natural Product Symposium, February 25-27, 2026. We are pleased to welcome the following speakers:
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.
Please spread the news and join us in Irsee!
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.
Please spread the news and join us in Irsee!
September 8, 2025 at 1:15 PM
We are organizing a session on SAM-dependent enzymes at the 38th Irsee Natural Product Symposium, February 25-27, 2026. We are pleased to welcome the following speakers:
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.
Please spread the news and join us in Irsee!
Prof. Andrea Rentmeister, Prof. Jörg Pietruszka, and Prof. Andreas Kirschning.
Please spread the news and join us in Irsee!
Greetings to all the doctoral researchers of the FOR5596 research unit who spent the last week at a summer school in Berlin!
July 2, 2025 at 11:23 AM
Greetings to all the doctoral researchers of the FOR5596 research unit who spent the last week at a summer school in Berlin!
Congratulations to FOR5596 member Andrea @rentmeisterlab.bsky.social for receiving the Wittig-Grignard Award!! 🎉
It was an honour to give a talk today in the historic lecture hall of Université Paris Cité, Faculté de Pharmacie after receiving the Wittig-Grignard Award yesterday. Thank you very much Bruno Sargueil and Mélanie Ethève-Quelquejeu for the invitation 🤩
April 30, 2025 at 3:34 PM
Congratulations to FOR5596 member Andrea @rentmeisterlab.bsky.social for receiving the Wittig-Grignard Award!! 🎉
Congratulations to all the authors of this paper, which just ranked in the top 10% of the most viewed papers published in ChemBioChem in 2023! We are very excited to be able to build on this amazing work in our FOR5596 research group.
@andexerlab.bsky.social @rentmeisterlab.bsky.social
@andexerlab.bsky.social @rentmeisterlab.bsky.social
Biomimetic S‐Adenosylmethionine Regeneration Starting from Multiple Byproducts Enables Biocatalytic Alkylation with Radical SAM Enzymes**
The biomimetic regeneration system for S-adenosylmethionine (SAM) and SAM analogues presented is based on the salvage of the adenine moiety and in situ supply of d-ribose and polyphosphate. It is com...
chemistry-europe.onlinelibrary.wiley.com
April 17, 2025 at 8:39 AM
Congratulations to all the authors of this paper, which just ranked in the top 10% of the most viewed papers published in ChemBioChem in 2023! We are very excited to be able to build on this amazing work in our FOR5596 research group.
@andexerlab.bsky.social @rentmeisterlab.bsky.social
@andexerlab.bsky.social @rentmeisterlab.bsky.social
Reposted by FOR5596 - SAM-dependent enzyme chemistry
Ever wondered why prenylation and methylation use different cofactor scaffolds? We now show that the SAM scaffold enables both: Chimeric cofactors enable methyltransferase-catalyzed prenylation: Chem www.cell.com/chem/fulltex... Kudos to @nicocorn.bsky.social & Arne Hoffmann and all authors 👌👏🤩
Chimeric cofactors enable methyltransferase-catalyzed prenylation
In nature, many methyltransferases (C1) use S-adenosyl-l-methionine (AdoMet or SAM)
as a cofactor for methyl transfer, whereas prenyltransferases (C5) use dimethylallyl
diphosphate (DMAPP). We enginee...
www.cell.com
April 9, 2025 at 6:00 PM
Ever wondered why prenylation and methylation use different cofactor scaffolds? We now show that the SAM scaffold enables both: Chimeric cofactors enable methyltransferase-catalyzed prenylation: Chem www.cell.com/chem/fulltex... Kudos to @nicocorn.bsky.social & Arne Hoffmann and all authors 👌👏🤩
Reposted by FOR5596 - SAM-dependent enzyme chemistry
If you want to know how to tell an N from an O, you can get some ideas in our new paper. This was a great team effort, introducing us to new methods: MD w/ Ferran Feixas & Marc Garcia Borràs (Girona) + HDX-MS w/ Wieland Steinchen & Gert Bange @bangebalcony.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
How to Tell an N from an O: Controlling the Chemoselectivity of Methyltransferases
S-Adenosyl-l-methionine (SAM)-dependent methyltransferases (MTs) are important enzymes in numerous biological pathways. They share a common SN2 mechanism but act on different nucleophilic substrates i...
pubs.acs.org
April 4, 2025 at 3:36 PM
If you want to know how to tell an N from an O, you can get some ideas in our new paper. This was a great team effort, introducing us to new methods: MD w/ Ferran Feixas & Marc Garcia Borràs (Girona) + HDX-MS w/ Wieland Steinchen & Gert Bange @bangebalcony.bsky.social
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
FOR 5596 is now on BlueSky! Follow us to stay informed about our collaborative project "Unfolding the potential of SAM-dependent enzyme chemistry".
April 2, 2025 at 2:20 PM
FOR 5596 is now on BlueSky! Follow us to stay informed about our collaborative project "Unfolding the potential of SAM-dependent enzyme chemistry".