⚡️GREG_CORDER⚡️
@flybottleescape.bsky.social
Assistant Professor @ Penn | Dept Psychiatry + Dept Neuroscience + Dept Anesthesiology | Pain • Placebo • Poppies • Psychedelics
https://corderlab.com/
https://corderlab.com/
Now officially: Dr Rogers🎓✨
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
December 12, 2025 at 9:34 PM
Now officially: Dr Rogers🎓✨
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
Unofficially: still the same Sophie.. with more letters + even more legend 🧠🍄💥
You crushed your thesis defense with equal parts science and soul. From psilocybin/psychedelics to pain + aversive processing in cortex you brought rigor, clarity and creative
Congrats 🍾
@sfn.org Come say hi to postdoc Blake Kimmey Tues, Nov. 18, 8:00 AM - 12:00 PM
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
November 17, 2025 at 5:47 PM
@sfn.org Come say hi to postdoc Blake Kimmey Tues, Nov. 18, 8:00 AM - 12:00 PM
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
PSTR278.07 - Convergent state-control of endogenous opioid analgesia
He's got new behavior/DREADD/Xenium data on PAG-to-thalamic circuits in pain/placebo/fear, building from his preprint: biorxiv.org/content/10.1...
FAAH inhibitors fail to replicate human KO reports. But check out the many cases of PAIN ASYMBOLIA that also suggest overlap between broad affective-motivational systems and “pain”(READ: unpleasantness) in BLA and posterior insula
September 25, 2025 at 12:20 AM
FAAH inhibitors fail to replicate human KO reports. But check out the many cases of PAIN ASYMBOLIA that also suggest overlap between broad affective-motivational systems and “pain”(READ: unpleasantness) in BLA and posterior insula
🙏 Please help!
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
September 18, 2025 at 6:20 PM
🙏 Please help!
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
ad nauseam topic but for new NIH n=6 submission policy is it:
a. 6 subs in 2025 calendar year = we can sub 6 R01s for Oct '25 + another 6 for Jan-Dec '26?
b. subs in Oct '25 w/ May '26 Council = we can sub 6 R01s Oct '25 to June '26; count resets Oct '26?
11. Last, using projection-specific + nociceptive intersectional chemogenetics we linked this BLA-->NAcSh cell-type to acute and chronic pain affective-motivational behaviors
July 24, 2025 at 2:02 PM
11. Last, using projection-specific + nociceptive intersectional chemogenetics we linked this BLA-->NAcSh cell-type to acute and chronic pain affective-motivational behaviors
10. BLA-noci axon-photometry over the NAcSh-noci ensemble showed nociceptive transmissions.
In fact, light-touch information used this nociceptive amygdala-striatal pathway during chronic pain states, indicating a role in aversion to allodynia
In fact, light-touch information used this nociceptive amygdala-striatal pathway during chronic pain states, indicating a role in aversion to allodynia
July 24, 2025 at 2:00 PM
10. BLA-noci axon-photometry over the NAcSh-noci ensemble showed nociceptive transmissions.
In fact, light-touch information used this nociceptive amygdala-striatal pathway during chronic pain states, indicating a role in aversion to allodynia
In fact, light-touch information used this nociceptive amygdala-striatal pathway during chronic pain states, indicating a role in aversion to allodynia
8. RNAseq suggested chronic pain alters to downstream axon regulation + signaling. We examined the projection targets of the BLA-noci ensemble to correlate axon density with brain-wide nociceptive hotspots
… we found one very interesting hit—the nucleus accumbens shell (NAcSh)
… we found one very interesting hit—the nucleus accumbens shell (NAcSh)
July 24, 2025 at 1:59 PM
8. RNAseq suggested chronic pain alters to downstream axon regulation + signaling. We examined the projection targets of the BLA-noci ensemble to correlate axon density with brain-wide nociceptive hotspots
… we found one very interesting hit—the nucleus accumbens shell (NAcSh)
… we found one very interesting hit—the nucleus accumbens shell (NAcSh)
7. But how does chronic pain impact the BLA transcriptomic landscape?
Next, comparing uninjured vs neuropathic injured groups we discovered multiple up/down-regulated genes that we are now exploring for therapeutic targeting
Next, comparing uninjured vs neuropathic injured groups we discovered multiple up/down-regulated genes that we are now exploring for therapeutic targeting
July 24, 2025 at 1:57 PM
7. But how does chronic pain impact the BLA transcriptomic landscape?
Next, comparing uninjured vs neuropathic injured groups we discovered multiple up/down-regulated genes that we are now exploring for therapeutic targeting
Next, comparing uninjured vs neuropathic injured groups we discovered multiple up/down-regulated genes that we are now exploring for therapeutic targeting
6. We subset the Rspo2+ neurons into IEG+ clusters responsive to noxious or innocuous stimuli and found functional heterogeneity in this “(-)valence” cell-type.
We found new markers for nociceptive nuclei, eg Htr2a—a target of psychedelics that we're now exploring for analgesia
We found new markers for nociceptive nuclei, eg Htr2a—a target of psychedelics that we're now exploring for analgesia
July 24, 2025 at 1:56 PM
6. We subset the Rspo2+ neurons into IEG+ clusters responsive to noxious or innocuous stimuli and found functional heterogeneity in this “(-)valence” cell-type.
We found new markers for nociceptive nuclei, eg Htr2a—a target of psychedelics that we're now exploring for analgesia
We found new markers for nociceptive nuclei, eg Htr2a—a target of psychedelics that we're now exploring for analgesia
5. A functional ensemble is not just one molecular cell-type right? Gene markers are proposed for (-)valence—Rspo2 + Fezf2
Using snRNAseq we mapped noxious immediate early genes (IEGs) to find two subtypes of Rspo2+ neurons not expressing Fezf2 or other “valence markers”
Using snRNAseq we mapped noxious immediate early genes (IEGs) to find two subtypes of Rspo2+ neurons not expressing Fezf2 or other “valence markers”
July 24, 2025 at 1:55 PM
5. A functional ensemble is not just one molecular cell-type right? Gene markers are proposed for (-)valence—Rspo2 + Fezf2
Using snRNAseq we mapped noxious immediate early genes (IEGs) to find two subtypes of Rspo2+ neurons not expressing Fezf2 or other “valence markers”
Using snRNAseq we mapped noxious immediate early genes (IEGs) to find two subtypes of Rspo2+ neurons not expressing Fezf2 or other “valence markers”
4. Chemogenetic activation of the BLA-noci ensemble drove conditioned place aversion in female TRAP2 mice only... extending similar BLA-noci activation studies with
@ishmailsaboor.bsky.social altering high-speed withdrawal responses selectively to noxious stimuli elifesciences.org/articles/57258
@ishmailsaboor.bsky.social altering high-speed withdrawal responses selectively to noxious stimuli elifesciences.org/articles/57258
July 24, 2025 at 1:54 PM
4. Chemogenetic activation of the BLA-noci ensemble drove conditioned place aversion in female TRAP2 mice only... extending similar BLA-noci activation studies with
@ishmailsaboor.bsky.social altering high-speed withdrawal responses selectively to noxious stimuli elifesciences.org/articles/57258
@ishmailsaboor.bsky.social altering high-speed withdrawal responses selectively to noxious stimuli elifesciences.org/articles/57258
3. Key, opto inhibition of the normal, acute-responsive BLA-noci ensemble is sufficient to selectively reduce behavioral signs of chronic pain weeks later, highlighting the stability of pain-processes for translational targeting, unlike representational drift in CS+ networks …
July 24, 2025 at 1:53 PM
3. Key, opto inhibition of the normal, acute-responsive BLA-noci ensemble is sufficient to selectively reduce behavioral signs of chronic pain weeks later, highlighting the stability of pain-processes for translational targeting, unlike representational drift in CS+ networks …
2. In TRAP2 mice (*homozygous* Fos-iCre-ERT2), Jess gained genetic access to the BLA-noci ensemble to show an anatomic-functional architecture that persisted before and after the induction of chronic pain
July 24, 2025 at 1:52 PM
2. In TRAP2 mice (*homozygous* Fos-iCre-ERT2), Jess gained genetic access to the BLA-noci ensemble to show an anatomic-functional architecture that persisted before and after the induction of chronic pain
🙌🏼 For Jess !!!
July 23, 2025 at 8:17 PM
🙌🏼 For Jess !!!
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
July 23, 2025 at 6:52 PM
⚡️🧠A nociceptive amygdala-striatal pathway modulating affective-motivational pain
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Now published on the cover of Science Advances @science.org
Check it out 👇
www.science.org/doi/10.1126/...
Huge congrats to Dr. Lisa Wooldridge!
She crushed her PhD defense on central amygdala circuits in opioid dependence
Incredible science, relentless rigor, and a fearless approach to tough questions
So proud to be part of your journey, Lisa!
🧠🔥🎓🍾
She crushed her PhD defense on central amygdala circuits in opioid dependence
Incredible science, relentless rigor, and a fearless approach to tough questions
So proud to be part of your journey, Lisa!
🧠🔥🎓🍾
July 1, 2025 at 11:35 PM
Huge congrats to Dr. Lisa Wooldridge!
She crushed her PhD defense on central amygdala circuits in opioid dependence
Incredible science, relentless rigor, and a fearless approach to tough questions
So proud to be part of your journey, Lisa!
🧠🔥🎓🍾
She crushed her PhD defense on central amygdala circuits in opioid dependence
Incredible science, relentless rigor, and a fearless approach to tough questions
So proud to be part of your journey, Lisa!
🧠🔥🎓🍾
ran the rest of the comparison with RSC trace fear conditioning data
June 27, 2025 at 9:26 PM
ran the rest of the comparison with RSC trace fear conditioning data
sophie the student, ran the rest of the Kanter et al code ... see results summary 👇
June 27, 2025 at 9:25 PM
sophie the student, ran the rest of the Kanter et al code ... see results summary 👇
Yea I’m reporting this one
June 27, 2025 at 1:08 PM
Yea I’m reporting this one
Met w student in morning to discuss “time tiling” in imaging across fear conditioning
Saw this new paper in the evening, sent to student
Woke up to student’s reanalysis using open-source code from this paper …
= retrosplineal drift with sharp jumps at tone+shock pairings vs extinction tones
Saw this new paper in the evening, sent to student
Woke up to student’s reanalysis using open-source code from this paper …
= retrosplineal drift with sharp jumps at tone+shock pairings vs extinction tones
June 27, 2025 at 1:04 PM
Met w student in morning to discuss “time tiling” in imaging across fear conditioning
Saw this new paper in the evening, sent to student
Woke up to student’s reanalysis using open-source code from this paper …
= retrosplineal drift with sharp jumps at tone+shock pairings vs extinction tones
Saw this new paper in the evening, sent to student
Woke up to student’s reanalysis using open-source code from this paper …
= retrosplineal drift with sharp jumps at tone+shock pairings vs extinction tones
🤮 more garbage takes in grant reviews .. we got a 5 and ultimately ND bc we have papers on bioRxiv that were to support the 20+ references for ACC/PAG/BLA roles in pain
.. punished for preprints, wtf
.. punished for preprints, wtf
June 26, 2025 at 6:53 PM
🤮 more garbage takes in grant reviews .. we got a 5 and ultimately ND bc we have papers on bioRxiv that were to support the 20+ references for ACC/PAG/BLA roles in pain
.. punished for preprints, wtf
.. punished for preprints, wtf
im also an alzheimer's researcher now too ... 😜
angry CD68+ microglia eating some X-34 dyed plaques
angry CD68+ microglia eating some X-34 dyed plaques
June 23, 2025 at 7:16 PM
im also an alzheimer's researcher now too ... 😜
angry CD68+ microglia eating some X-34 dyed plaques
angry CD68+ microglia eating some X-34 dyed plaques
Peer review is so fucked …
Reviewer 2: “Nice 5-year study. Now add 10–15 more years of data you’d need a second lifetime to collect and 3 R01s, and so I’m just gonna reject.”
Me: “Cool cool cool.. Maybe. Maybe not. Maybe go fuck yourself.”
Reviewer 2: “Nice 5-year study. Now add 10–15 more years of data you’d need a second lifetime to collect and 3 R01s, and so I’m just gonna reject.”
Me: “Cool cool cool.. Maybe. Maybe not. Maybe go fuck yourself.”
June 19, 2025 at 9:38 PM
Peer review is so fucked …
Reviewer 2: “Nice 5-year study. Now add 10–15 more years of data you’d need a second lifetime to collect and 3 R01s, and so I’m just gonna reject.”
Me: “Cool cool cool.. Maybe. Maybe not. Maybe go fuck yourself.”
Reviewer 2: “Nice 5-year study. Now add 10–15 more years of data you’d need a second lifetime to collect and 3 R01s, and so I’m just gonna reject.”
Me: “Cool cool cool.. Maybe. Maybe not. Maybe go fuck yourself.”
