Florian Gabler
@floriangabler.bsky.social
Ikmi lab at EMBL Heidelberg
Excited by emergent behaviors during development
Medical student at Heidelberg University
Excited by emergent behaviors during development
Medical student at Heidelberg University
Reposted by Florian Gabler
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 13, 2025 at 4:20 PM
New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Florian Gabler
How to swap the foot for a tentacle and vice versa? Find out in our new story featured in @dev-journal.bsky.social uncovering a transcription factor toggle switch behind the identity of Hydra's extremities.
Issue 17 is complete!
On the cover: Image of three Hydra specimens. A wild-type Hydra (centre) and two transformants showing switch of foot (pink) to tentacle (yellow) (right) and tentacles to feet (left).
See Research Article by Ferenc et al.
journals.biologists.com/dev/article/...
On the cover: Image of three Hydra specimens. A wild-type Hydra (centre) and two transformants showing switch of foot (pink) to tentacle (yellow) (right) and tentacles to feet (left).
See Research Article by Ferenc et al.
journals.biologists.com/dev/article/...
October 1, 2025 at 3:04 PM
How to swap the foot for a tentacle and vice versa? Find out in our new story featured in @dev-journal.bsky.social uncovering a transcription factor toggle switch behind the identity of Hydra's extremities.
Reposted by Florian Gabler
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
August 22, 2025 at 6:11 AM
🚨 New paper out in @pnas.org! 🚨
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
We show that self-generated gradients allow heterogeneous cell mixtures to co-migrate efficiently over long distances —while optimizing their physical interactions!
(See below for 🧵)
www.pnas.org/doi/10.1073/... 🧪
Reposted by Florian Gabler
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
August 7, 2025 at 1:38 PM
Spent a memorable summer at Physiology course at @mblscience.bsky.social Very coooool science with some lovely people! Thanks @brangwynnelab.bsky.social and @gladfelterlab.bsky.social for being amazinnnng course coordinators! 🧵
Reposted by Florian Gabler
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
June 24, 2025 at 4:52 PM
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Florian Gabler
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
June 11, 2025 at 4:47 PM
🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
“A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶
🔗 www.biorxiv.org/content/10.1...
#devbio #biophysics
🧵⤵️
Reposted by Florian Gabler
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
March 31, 2025 at 1:11 PM
We may not have really squared the circle — but we came close! 😉 In our @NaturePhysics paper w/ @fakhrilab.bsky.social, light-triggered membrane excitability enables programmable shapes — a step toward engineering living matter.
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
🔗 www.nature.com/articles/s41...
#biophysics #syntheticcell #softmatter
Reposted by Florian Gabler
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
March 27, 2025 at 2:16 PM
🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social !
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌
🧵⤵️
🚀 Did you know that you can now do selection-free CRISPR-Cas9 in Dictyostelid species? You can achieve 80% KO and 30% KI efficiencies in D. discoideum! Check out the new preprint from the van Gestel group @jordivangestel.bsky.social in the DB unit @embl.org
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Selection-free CRISPR-Cas9 editing protocol for distant Dictyostelid species
Dictyostelids are a species-rich clade of cellular slime molds that are widely found in soils and have been studied for over a century. Most research focusses on Dictyostelium discoideum, which - due ...
www.biorxiv.org
March 26, 2025 at 6:42 PM
Reposted by Florian Gabler
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
March 25, 2025 at 2:37 PM
I am very happy to share that my work on active deformations of lipid vesicles is finally out in Nature Physics. A nicer thread+movies coming soon, in the meantime:
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
www.nature.com/articles/s41...
Thx to Andreas, Hammad, Dmitry, Gerhard @laynefrechette.bsky.social and everybody else who contributed!
Reposted by Florian Gabler
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
March 18, 2025 at 11:27 PM
There are days in life that shake you.
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵
Reposted by Florian Gabler
As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social
February 26, 2025 at 5:40 PM
As the world of science wakes up to modern fascism, it's worth remembering older generations who stood up for humanity in much harsher circumstances. Jacques Monod worked actively for the resistance in WWII, while pursuing early stages of his research in occupied Paris. @standupforscifr.bsky.social
Reposted by Florian Gabler
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 26, 2025 at 9:13 AM
New preprint out 🔥🔥 on my postdoc work with @manuelthery.bsky.social and @lblanchoin.bsky.social about how we can create sustained dynamic steady states of actin network inside microscopic wells that contract "forever" without collapsing! A thread 🧵
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Florian Gabler
In anticipation/angst for the coming German election, thinking of finally buying a mandolin
February 21, 2025 at 8:43 AM
In anticipation/angst for the coming German election, thinking of finally buying a mandolin
Reposted by Florian Gabler
Well well, timely! 😉
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Should biology put complexity first?
The dictum “Everything should be made as simple as possible, but no simpler” poses
a problem for biology. How simply can it be told without doing damage to its complex
nature? The answer might be foun...
www.cell.com
February 20, 2025 at 1:39 PM
Well well, timely! 😉
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Reposted by Florian Gabler
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 11:41 AM
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Florian Gabler
🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬
doi.org/10.1101/2025...
Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
doi.org/10.1101/2025...
Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
February 11, 2025 at 6:02 PM
🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬
doi.org/10.1101/2025...
Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
doi.org/10.1101/2025...
Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
Reposted by Florian Gabler
The evolution of shape diversity through the lens of physics—explored in our new paper! A fruitful collaboration between our lab @EMBL, Salbreux’s lab @unige & others, led by @BailleulRichar1—now independent at @ENS_ULM—& Nicolas Cuny. bit.ly/3WRqdEa
February 9, 2025 at 12:39 PM
The evolution of shape diversity through the lens of physics—explored in our new paper! A fruitful collaboration between our lab @EMBL, Salbreux’s lab @unige & others, led by @BailleulRichar1—now independent at @ENS_ULM—& Nicolas Cuny. bit.ly/3WRqdEa
Reposted by Florian Gabler
I have run out of patience with the apparent silence of most US science institutions (and not just US) in the face of Trump & Musk's rampage. There are of so many facets of that, but in this column for @chemistryworld.com I talk about the assaults on inclusion.
www.chemistryworld.com/opinion/scie...
www.chemistryworld.com/opinion/scie...
Scientific institutions have a long history of anticipatory obedience
Societies should learn from this and speak up to support inclusion
www.chemistryworld.com
February 7, 2025 at 3:02 PM
I have run out of patience with the apparent silence of most US science institutions (and not just US) in the face of Trump & Musk's rampage. There are of so many facets of that, but in this column for @chemistryworld.com I talk about the assaults on inclusion.
www.chemistryworld.com/opinion/scie...
www.chemistryworld.com/opinion/scie...
Reposted by Florian Gabler
Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A toolkit for testing membrane localisation tags across species
Transgenic markers and tools have revolutionised how we study cells and developing organisms. Some of the elements needed to construct those tools are universally applicable (e.g. fluorescent proteins...
www.biorxiv.org
November 12, 2024 at 11:05 PM
Looking for a tag to localise fluorescent proteins to the plasma membrane? Unsure which tag might work in your species? We generated a toolkit of 11 membrane-localising tags, which can be screened rapidly by microinjecting mRNA in your species of interest. 1/4
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...