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flalom.bsky.social
flalom
@flalom.bsky.social
Postdoc in computational biology/bioinformatics
Reposted by flalom
Since writing this paper, we've released Proseg 2, adding support for higher plex assays (e.g. Xenium Prime), and we're hard at work on Proseg 3 which adds support for sequencing based methods like Visium HD and Stereo-Seq.

Code is here: github.com/dcjones/proseg
Or just run: cargo install proseg
GitHub - dcjones/proseg: Probabilistic cell segmentation for in situ spatial transcriptomics
Probabilistic cell segmentation for in situ spatial transcriptomics - dcjones/proseg
github.com
May 22, 2025 at 5:52 PM
Reposted by flalom
Finally, if you are interested in splicing and NMD, do also check out this paper from Yang Li's group: www.nature.com/articles/s41...
Global impact of unproductive splicing on human gene expression - Nature Genetics
Genomic analyses suggest that ~15% of transcript molecules are spliced into unproductive transcripts targeted by nonsense-mediated decay, which have a larger effect on gene expression than previously ...
www.nature.com
December 30, 2024 at 3:25 PM