Fischbach Lab
@fischbachlab.bsky.social
Lab of Dr. Claudia Fischbach at Cornell BME. We apply engineering principles to understand how tissue microenvironments influence cancer. Run by lab members.
https://fischbachlab.bme.cornell.edu
https://fischbachlab.bme.cornell.edu
Reposted by Fischbach Lab
Tumour heterogeneity comes at different length scales.This article classifies regulators of cancer into tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, describing engineering strategies to measure and analyse these factors:
Measuring and modelling tumour heterogeneity across scales - Nature Reviews Bioengineering
Heterogeneity constitutes a critical barrier to treating cancer. This Review discusses the biological and physical sources of heterogeneity across length scales, encompassing tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, and how engineering strategies can improve our understanding of these phenomena.
go.nature.com
April 27, 2025 at 2:02 PM
Tumour heterogeneity comes at different length scales.This article classifies regulators of cancer into tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, describing engineering strategies to measure and analyse these factors:
Reposted by Fischbach Lab
Had a great time working with @natrevbioeng.nature.com to put this review together! Biophysical cues integrate across length scales (molecular, cellular, tissue level, organismal) to drive cancer outcomes. Bioengineers have the tools to measure and model these factors in isolation 🛠️🔬
Tumour heterogeneity comes at different length scales.This article classifies regulators of cancer into tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, describing engineering strategies to measure and analyse these factors:
Measuring and modelling tumour heterogeneity across scales - Nature Reviews Bioengineering
Heterogeneity constitutes a critical barrier to treating cancer. This Review discusses the biological and physical sources of heterogeneity across length scales, encompassing tumour-cell-intrinsic, tissue-microenvironment and organism-level sources, and how engineering strategies can improve our understanding of these phenomena.
go.nature.com
April 27, 2025 at 3:39 PM
Had a great time working with @natrevbioeng.nature.com to put this review together! Biophysical cues integrate across length scales (molecular, cellular, tissue level, organismal) to drive cancer outcomes. Bioengineers have the tools to measure and model these factors in isolation 🛠️🔬
Reposted by Fischbach Lab
Preprint alert! Excited to share this manuscript from my PhD which aims to answer an age-old question. Does size matter? For fat cells, or adipocytes, the answer seems to be yes. We found that larger adipocytes promote aggressive behavior in breast cancer cells. 1/5 www.biorxiv.org/content/10.1...
Hypertrophic adipocytes increase extracellular vesicle-mediated lipid release and reprogram breast cancer cell metabolism
Obesity worsens cancer-specific survival and all-cause mortality for women diagnosed with breast cancer. Rich in adipose tissue, the breast exhibits increased adipocyte size in obesity, which correlat...
www.biorxiv.org
April 7, 2025 at 6:45 PM
Preprint alert! Excited to share this manuscript from my PhD which aims to answer an age-old question. Does size matter? For fat cells, or adipocytes, the answer seems to be yes. We found that larger adipocytes promote aggressive behavior in breast cancer cells. 1/5 www.biorxiv.org/content/10.1...