Kate Caturjelly
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firekesti.net
Kate Caturjelly
@firekesti.net
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Reposted by Kate Caturjelly
sarahjeong.bsky.social
how did i go so long not knowing we were literally teaching people to read wrong. i knew something wasn't right but jesus christ www.apmreports.org/episode/2019...
How a flawed idea is teaching millions of kids to be poor readers
For decades, schools have taught children the strategies of struggling readers, using a theory about reading that cognitive scientists have repeatedly debunked. And many teachers and parents don't kno...
www.apmreports.org
November 11, 2025 at 6:18 PM
firekesti.net
no - it can't be eaten using ONLY a spoon
November 12, 2025 at 1:46 AM
Reposted by Kate Caturjelly
sailorrooscout.bsky.social
Researchers envision their vaccine being used as both a treatment and a preventive, and as an approach to treating multiple cancer types.
• www.umass.edu/news/article...

The study has been published in Cell Reports Medicine. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
HIGHLIGHTS • Lipid NPs carrying STING and TLR4 agonists promote synergistic type I interferons • NPs drain efficiently to lymph nodes and increase polyfunctional T and B cells • NPs improve tumor-free outcomes with memory against multiple aggressive tumor models SUMMARY We report on the utility of a "super-adjuvant" nanoparticle (NP) system as a modular, customizable platform for next-generation cancer vaccination. Using nanomaterials engineering technology, we aim to harness not only the effective adjuvanticity of whole-pathogen vaccines, but also the safety of subunit vaccines. Our lipid-based NP platform co-encapsulates agonists of the stimulator of interferon genes (STING) and Toll-like receptor 4 (TLR4) pathways to promote synergistic production of type I interferons and other proinflammatory cytokines in innate antigen-presenting dendritic cells and macrophages. Compared to empty NPs and free agonists, dual-adjuvant NPs administered with antigenic peptides or tumor cell lysate promote increased antigen processing and presentation, drain efficiently to nearby lymph nodes, increase polyfunctional tumor-specific T and B cells, and improve tumor-free outcomes upon vaccination and subsequent challenge with multiple aggressive tumor cells. Graphical Abstract The vaccine combines two immune-stimulating molecules (adjuvants) in a tiny lipid nanoparticle that enhances both innate and adaptive immune responses. The innate immune system acts as the body’s first line of defense, responding quickly and non-specifically to invaders using cells that release inflammatory signals. The adaptive immune system takes longer to activate but provides a targeted, long-lasting response, training T-cells and B- cells to recognize and remember specific threats. Together, they form a coordinated defense: the innate system alerts and activates the adaptive system, which then delivers precise and durable immunity.
November 5, 2025 at 5:02 PM
Reposted by Kate Caturjelly
allegrak.bsky.social
Teen Vogue was one of the only outlets that took young people seriously as political actors and covered how they're organizing, voting, and being impacted by state + national legislation.

It was a launching pad for so many great young journalists
November 3, 2025 at 9:14 PM