Filip Van Petegem
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filipvanpetegem.bsky.social
Filip Van Petegem
@filipvanpetegem.bsky.social
Protein Biochemist. Structural Biology. Cardiac arrhythmias. Muscle excitation-contraction coupling. MTB and road biking. Music arrangements.

https://www.vanpetegemlab.com
Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...
November 21, 2025 at 6:42 PM
Our cryo-EM structure of the intermediate state of the KCNQ1 potassium channel is out. Collaborative effort with the David Fedida and Luca Maragliano labs. Cryo-EM work spearheaded by Efthimios Kyriakis, PhD

www.nature.com/articles/s41...
October 3, 2025 at 6:44 PM
Stress in action: our crystal structure of PKA bound to its preferred substrate in CaV1.2 (Ser1981 for the aficionados). Quantitative experiments on previously proposed sites in CaV1.2 and its regulator Rad shows that there are two tiers of substrates.

jbc.org/article/S002...
November 29, 2024 at 9:29 PM
Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting.
(description also here: www.science.org/doi/10.1126/...)
November 23, 2024 at 10:20 PM
Every day since the late 1920s (except during WWII), the notes of the Last Post sound through the Menin Gate in Ypres, Belgium. Unfortunately, "never again" hasn't stuck. #ArmisticeDay
November 11, 2024 at 5:41 PM
October 5, 2024 at 3:49 AM