Joseph Festa
@festascience.bsky.social
Currently completing a postdoc in immunometabolism at the Trefely Lab, Babraham Institute, Cambridge.
Reposted by Joseph Festa
very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...
Metabolites in the extracellular tumor microenvironment and the shaping of macrophage function
It has been a century since it was discovered that cancer cells have a distorted metabolism compared to healthy cells and tissues. It is now universal…
www.sciencedirect.com
October 22, 2025 at 1:00 PM
very nice review about how metabolic changes in the tumour microenvironment affect macrophage function: www.sciencedirect.com/science/arti...
Reposted by Joseph Festa
People with some cancers live longer after COVID vaccination 😮
mRNA vaccines can augment immune checkpoint inhibition efficacy for patients with skin or lung cancers - by globally boosting immune responses 💉🧪⚕️
www.nature.com/articles/d41...
Grippen et al study:
www.nature.com/articles/s41...
mRNA vaccines can augment immune checkpoint inhibition efficacy for patients with skin or lung cancers - by globally boosting immune responses 💉🧪⚕️
www.nature.com/articles/d41...
Grippen et al study:
www.nature.com/articles/s41...
People with some cancers live longer after a COVID vaccine
mRNA vaccines seem to boost the effectiveness of an immune therapy for skin and lung cancer ― in an unexpected way.
www.nature.com
October 22, 2025 at 6:08 PM
People with some cancers live longer after COVID vaccination 😮
mRNA vaccines can augment immune checkpoint inhibition efficacy for patients with skin or lung cancers - by globally boosting immune responses 💉🧪⚕️
www.nature.com/articles/d41...
Grippen et al study:
www.nature.com/articles/s41...
mRNA vaccines can augment immune checkpoint inhibition efficacy for patients with skin or lung cancers - by globally boosting immune responses 💉🧪⚕️
www.nature.com/articles/d41...
Grippen et al study:
www.nature.com/articles/s41...
Reposted by Joseph Festa
Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 6:58 AM
Tumor nutrient stress gives rise to a drug tolerant cell state in #PancreaticCancer 🧪 www.biorxiv.org/content/10.1...
Reposted by Joseph Festa
New #cancer study showing that tumor cell #clusters in the blood (which are more #metastatic) can be disrupted by the drug digoxin - in an exciting proof of concept trial 🧪
Kurzeder, Aceto et al, ETH Zurich
Commentary by Smit & Pantel
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Kurzeder, Aceto et al, ETH Zurich
Commentary by Smit & Pantel
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Breaking up clusters of circulating tumour cells to halt cancer spread
The drug digoxin reduces the clustering of tumour cells.
www.nature.com
January 28, 2025 at 3:39 PM
New #cancer study showing that tumor cell #clusters in the blood (which are more #metastatic) can be disrupted by the drug digoxin - in an exciting proof of concept trial 🧪
Kurzeder, Aceto et al, ETH Zurich
Commentary by Smit & Pantel
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Kurzeder, Aceto et al, ETH Zurich
Commentary by Smit & Pantel
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Joseph Festa
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lithocholic acid phenocopies anti-ageing effects of calorie restriction - Nature
Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restric...
www.nature.com
December 18, 2024 at 5:35 PM
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
www.nature.com/articles/s41...
www.nature.com/articles/s41...