Fergal Waldron
@fergalwaldron.bsky.social
Advanced Research Fellow, University of Aberdeen | ALS/MND/FTD | Early diagnosis & precision-prevention | Biomarkers | Disease Heterogeneity | Non-motor symptoms
Reposted by Fergal Waldron
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
October 16, 2025 at 7:02 AM
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
http://medrxiv.org/cgi/content/short/2025.10.13.25337884v1
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset
Background : Disease-modifying therapies for neurodegenerative disorders are unlikely to succeed once symptoms emerge, as significant neuronal loss has already occurred. Accessible biomarkers that pre...
www.medrxiv.org
October 16, 2025 at 9:07 AM
🧠New preprint: Neurodegeneration-associated proteinopathies are not confined to the brain, they can be detected in routine GI biopsies, years before symptom onset.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Fergal Waldron
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset https://www.medrxiv.org/content/10.1101/2025.10.13.25337884v1
October 16, 2025 at 4:58 AM
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset https://www.medrxiv.org/content/10.1101/2025.10.13.25337884v1
Reposted by Fergal Waldron
#Medsky🧪 #neurosky #immunosky Studies are investigating a link between #proteinmisfolding in GIT & the development of #neurodegenerativediseases like #Parkinson & #Alzheimer often years before symptoms appear.
Protein misfolding in the gastrointestinal tract predicts and prognosticates neurodegenerative disease years before symptom onset https://www.medrxiv.org/content/10.1101/2025.10.13.25337884v1
October 16, 2025 at 5:39 AM
#Medsky🧪 #neurosky #immunosky Studies are investigating a link between #proteinmisfolding in GIT & the development of #neurodegenerativediseases like #Parkinson & #Alzheimer often years before symptoms appear.
Reposted by Fergal Waldron
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis https://www.biorxiv.org/content/10.1101/2025.10.02.680028v1
October 4, 2025 at 12:15 AM
Brain Iron as a Surrogate Biomarker of Pathological TDP-43 Identifies Brain Region-Specific Signatures in Ageing, Alzheimer's Disease and Amyotrophic Lateral Sclerosis https://www.biorxiv.org/content/10.1101/2025.10.02.680028v1
At LifeArc's recent 1st ever Translational Science Summit on MND & Rare Dementias, Clinical Prof. Jenna Gregory
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
March 14, 2025 at 4:02 PM
At LifeArc's recent 1st ever Translational Science Summit on MND & Rare Dementias, Clinical Prof. Jenna Gregory
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
from @uniofaberdeen.bsky.social set out a vision for early diagnosis & prevention in #MND #ALS through learning from cancer, early detection tools, & a focus on prevention 🧵1/3
Reposted by Fergal Waldron
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 5:47 PM
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in @naturegenet.bsky.social with @trajnp.bsky.social and @panosroussos.bsky.social @sinaibrain.bsky.social www.nature.com/articles/s41...
Reposted by Fergal Waldron
Many thanks for the post - I am also recruiting for a postdoctoral Research Associate post in complex Human Organoid-based ALS disease modelling: www.jobs.cam.ac.uk/job/49564/
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Clinical Neurosciences at the University of Cambridge.
www.jobs.cam.ac.uk
December 17, 2024 at 2:49 PM
Many thanks for the post - I am also recruiting for a postdoctoral Research Associate post in complex Human Organoid-based ALS disease modelling: www.jobs.cam.ac.uk/job/49564/