Federica Mosti
@federicamosti.bsky.social
Neurodevelopment, Evolution, Epigenetics, Chromatin Interactions | PhD candidate Silver Lab Duke University | 🇮🇹
Reposted by Federica Mosti
“Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans”
New work on HAQERs, by
@rimangan.bsky.social Yanting Luo Craig Lowe @debbysilver.bsky.social @manoliskellis.bsky.social & colleagues
🧪🧬
www.biorxiv.org/content/10.1...
New work on HAQERs, by
@rimangan.bsky.social Yanting Luo Craig Lowe @debbysilver.bsky.social @manoliskellis.bsky.social & colleagues
🧪🧬
www.biorxiv.org/content/10.1...
Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans
Humans exhibit significant phenotypic differences from other great apes, yet pinpointing the underlying genetic changes has been limited by incomplete reference genomes and a reliance on single assemb...
www.biorxiv.org
October 21, 2025 at 10:14 AM
“Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans”
New work on HAQERs, by
@rimangan.bsky.social Yanting Luo Craig Lowe @debbysilver.bsky.social @manoliskellis.bsky.social & colleagues
🧪🧬
www.biorxiv.org/content/10.1...
New work on HAQERs, by
@rimangan.bsky.social Yanting Luo Craig Lowe @debbysilver.bsky.social @manoliskellis.bsky.social & colleagues
🧪🧬
www.biorxiv.org/content/10.1...
Reposted by Federica Mosti
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Reposted by Federica Mosti
Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual
https://go.nature.com/3GOTQkz
https://go.nature.com/3GOTQkz
Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
go.nature.com
May 14, 2025 at 3:41 PM
Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual
https://go.nature.com/3GOTQkz
https://go.nature.com/3GOTQkz
Amazing work from the Silver Lab! Grateful to have been part of such meaningful story!
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:38 PM
Amazing work from the Silver Lab! Grateful to have been part of such meaningful story!
Reposted by Federica Mosti
Happy to see my PhD work in the Fleischmann lab at Brown University @carneyinstitute.bsky.social published in
@natureneuro.bsky.social! -Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution nature.com/articles/s41...
@natureneuro.bsky.social! -Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution nature.com/articles/s41...
April 8, 2025 at 8:18 PM
Happy to see my PhD work in the Fleischmann lab at Brown University @carneyinstitute.bsky.social published in
@natureneuro.bsky.social! -Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution nature.com/articles/s41...
@natureneuro.bsky.social! -Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution nature.com/articles/s41...
Reposted by Federica Mosti
Happy to share some good news today, and our latest study on DDX3X! Led by super talented @federicamosti.bsky.social we use live imaging, transcriptomics and interaction studies to define how clinically diverse missense mutations in DDX3X influence neural development. dx.plos.org/10.1371/jour...
Multi-modal investigation reveals pathogenic features of diverse DDX3X missense mutations
Author summary DDX3X mutations are associated with neurodevelopmental disorders, including DDX3X syndrome and autism spectrum disorder. DDX3X is an RNA binding protein whose loss of function impairs b...
dx.plos.org
January 23, 2025 at 2:05 AM
Happy to share some good news today, and our latest study on DDX3X! Led by super talented @federicamosti.bsky.social we use live imaging, transcriptomics and interaction studies to define how clinically diverse missense mutations in DDX3X influence neural development. dx.plos.org/10.1371/jour...