Fernando Capelastegui
@fcapelastegui.bsky.social
Epidemiologist and biologist 📈🧬🦠. PhD Student @RoyalVetCollege.
Interested in avian influenza, zoonosis and emerging disease
Interested in avian influenza, zoonosis and emerging disease
Reposted by Fernando Capelastegui
🚨New Paper!🚨
Some like it hot: Matt Turnbull and @samjwilsonphd.bsky.social collaborated with groups from @cvrinfo.bsky.social, @cam.ac.uk and beyond to show that, while our fevers are hot enough to control human flu, they don't protect against avian influenzas adaptd to the hotter bodies of birds
Some like it hot: Matt Turnbull and @samjwilsonphd.bsky.social collaborated with groups from @cvrinfo.bsky.social, @cam.ac.uk and beyond to show that, while our fevers are hot enough to control human flu, they don't protect against avian influenzas adaptd to the hotter bodies of birds
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...
www.science.org
November 28, 2025 at 9:15 AM
🚨New Paper!🚨
Some like it hot: Matt Turnbull and @samjwilsonphd.bsky.social collaborated with groups from @cvrinfo.bsky.social, @cam.ac.uk and beyond to show that, while our fevers are hot enough to control human flu, they don't protect against avian influenzas adaptd to the hotter bodies of birds
Some like it hot: Matt Turnbull and @samjwilsonphd.bsky.social collaborated with groups from @cvrinfo.bsky.social, @cam.ac.uk and beyond to show that, while our fevers are hot enough to control human flu, they don't protect against avian influenzas adaptd to the hotter bodies of birds
Reposted by Fernando Capelastegui
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
November 11, 2025 at 8:38 PM
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
Reposted by Fernando Capelastegui
🚨New preprint🚨
In a multidisciplinary tour-de-force, @itingtu.bsky.social shows that, because #H5N1 flu is now routinely infecting seals and sealions in Peru, it's also spilling over into the vampire bats that feed from beaches...
🦭🦠🦇
(1/2)
In a multidisciplinary tour-de-force, @itingtu.bsky.social shows that, because #H5N1 flu is now routinely infecting seals and sealions in Peru, it's also spilling over into the vampire bats that feed from beaches...
🦭🦠🦇
(1/2)
My 1st first-author paper is out as a preprint! Excited to share the fascinating story of marine-feeding vampire bats 🌊🦇 We found that marine-diet bats were exposed to #H5#AvianFlu 🦠 from marine wildlife and could potentially spread it to livestock via blood feed🩸
doi.org/10.1101/2025.11.09.686930
doi.org/10.1101/2025.11.09.686930
November 12, 2025 at 11:33 AM
🚨New preprint🚨
In a multidisciplinary tour-de-force, @itingtu.bsky.social shows that, because #H5N1 flu is now routinely infecting seals and sealions in Peru, it's also spilling over into the vampire bats that feed from beaches...
🦭🦠🦇
(1/2)
In a multidisciplinary tour-de-force, @itingtu.bsky.social shows that, because #H5N1 flu is now routinely infecting seals and sealions in Peru, it's also spilling over into the vampire bats that feed from beaches...
🦭🦠🦇
(1/2)
Reposted by Fernando Capelastegui
Grateful to spend two days on the Klamath watching chinook, liberated by dam removal, return to streams from which they’d been precluded since the Titanic sank. Fish are everywhere, in numbers that stagger the mind & locations that biologists figured would take years to repopulate. Too beautiful.
November 5, 2025 at 9:17 PM
Grateful to spend two days on the Klamath watching chinook, liberated by dam removal, return to streams from which they’d been precluded since the Titanic sank. Fish are everywhere, in numbers that stagger the mind & locations that biologists figured would take years to repopulate. Too beautiful.
Reposted by Fernando Capelastegui
Now out in @nejm.org :
Between 2023–2024: Sixteen human infections with A/H5N1 in Cambodia. Six deaths. Most in children. All exposed to sick or dead poultry.
www.nejm.org/doi/full/10....
Between 2023–2024: Sixteen human infections with A/H5N1 in Cambodia. Six deaths. Most in children. All exposed to sick or dead poultry.
www.nejm.org/doi/full/10....
Resurgence of Zoonotic Highly Pathogenic Avian Influenza A(H5N1) Virus in Cambodia | NEJM
In this report from Cambodia, 16 human cases of highly pathogenic avian influenza
A(H5N1) virus infection that occurred from February 2023 through August 2024 are described.
www.nejm.org
October 23, 2025 at 5:04 AM
Now out in @nejm.org :
Between 2023–2024: Sixteen human infections with A/H5N1 in Cambodia. Six deaths. Most in children. All exposed to sick or dead poultry.
www.nejm.org/doi/full/10....
Between 2023–2024: Sixteen human infections with A/H5N1 in Cambodia. Six deaths. Most in children. All exposed to sick or dead poultry.
www.nejm.org/doi/full/10....
Reposted by Fernando Capelastegui
Excited to present the first review from my lab!
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
June 10, 2025 at 12:44 PM
Excited to present the first review from my lab!
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
Which mutations allow H5 influenza to jump into humans or other mammals? How close is H5 to a pandemic? This review has the answers and explains the molecular mechanism behind the mutations.
Led by @fcapelastegui.bsky.social.
doi.org/10.1099/jgv....
Reposted by Fernando Capelastegui
Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...
Timing and molecular characterisation of the transmission to cattle of H5N1 influenza A virus genotype D1.1, clade 2.3.4.4b
Jonathan E. Pekar, Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK Thomas P. Peacock, The Pirbright Institute, Woking, UK, GU24 0NF; Department of Infectious Disease, Imper...
virological.org
February 24, 2025 at 1:25 PM
Our analysis of the second incursion of H5N1 viruses (genotype D1.1) into dairy cattle in the US is now posted to virological virological.org/t/timing-and...
Reposted by Fernando Capelastegui
Our mSCAPE project has been formally announced to the world by @smhopkins.bsky.social at #FOG2025 today: www.gov.uk/government/n... - a really exciting academic-public health collaboration to build a surveillance platform leveraging NHS metagenomic diagnostic data. @meerac.bsky.social
UKHSA launches new metagenomic surveillance for health security
The UK launches mSCAPE, a world-first metagenomics initiative by UKHSA to enhance health security through rapid pathogen detection and surveillance.
www.gov.uk
January 30, 2025 at 4:54 PM
Our mSCAPE project has been formally announced to the world by @smhopkins.bsky.social at #FOG2025 today: www.gov.uk/government/n... - a really exciting academic-public health collaboration to build a surveillance platform leveraging NHS metagenomic diagnostic data. @meerac.bsky.social
Reposted by Fernando Capelastegui
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. https://www.biorxiv.org/content/10.1101/2025.01.06.631435v1
January 7, 2025 at 7:18 AM
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals. https://www.biorxiv.org/content/10.1101/2025.01.06.631435v1
Reposted by Fernando Capelastegui
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
Polymerase mutations underlie adaptation of H5N1 influenza virus to dairy cattle and other mammals.
In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...
www.biorxiv.org
January 7, 2025 at 7:59 AM
Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
Reposted by Fernando Capelastegui
Pentametron was one of the great web art projects, retweeting couplets of accidentally iambic tweets. Thanks to Bluesky's open feed, I have resurrected the concept..
Behold @iambic.bot!
Behold @iambic.bot!
November 30, 2024 at 3:26 PM
Pentametron was one of the great web art projects, retweeting couplets of accidentally iambic tweets. Thanks to Bluesky's open feed, I have resurrected the concept..
Behold @iambic.bot!
Behold @iambic.bot!