Brandon Faubert
@faubert.bsky.social
9/Thanks to @rjdlab.bsky.social for all of his support, guidance, and patience over the years.
And finally, to all the patients who joined our study and donated tissue- Thank you. We hope this work accelerates further discoveries in NSCLC
And finally, to all the patients who joined our study and donated tissue- Thank you. We hope this work accelerates further discoveries in NSCLC
February 17, 2025 at 8:37 PM
9/Thanks to @rjdlab.bsky.social for all of his support, guidance, and patience over the years.
And finally, to all the patients who joined our study and donated tissue- Thank you. We hope this work accelerates further discoveries in NSCLC
And finally, to all the patients who joined our study and donated tissue- Thank you. We hope this work accelerates further discoveries in NSCLC
8/A special thanks to Dr. Kemp Kernstine, without him none of this work would have been possible.
In my lab, I'm fortunate to have a fun, hardworking, collaborative team. A special thanks to @niahammond.bsky.social, who has spearheaded all of our metabolic and metastatic mouse work
In my lab, I'm fortunate to have a fun, hardworking, collaborative team. A special thanks to @niahammond.bsky.social, who has spearheaded all of our metabolic and metastatic mouse work
February 17, 2025 at 8:34 PM
8/A special thanks to Dr. Kemp Kernstine, without him none of this work would have been possible.
In my lab, I'm fortunate to have a fun, hardworking, collaborative team. A special thanks to @niahammond.bsky.social, who has spearheaded all of our metabolic and metastatic mouse work
In my lab, I'm fortunate to have a fun, hardworking, collaborative team. A special thanks to @niahammond.bsky.social, who has spearheaded all of our metabolic and metastatic mouse work
7/ In my opinion, this project has been a fantastic example of team science, and I'm grateful to have worked with so many great collaborators, clinicians, surgeons, pathologists
February 17, 2025 at 8:31 PM
7/ In my opinion, this project has been a fantastic example of team science, and I'm grateful to have worked with so many great collaborators, clinicians, surgeons, pathologists
6/We found that inhibiting complex I in the mitochondria was able to reduce metastatic dissemination in these models.
We still need to figure out the contexts in which TCA and ETC are needed in supporting metastasis, and how this may change in specific organ environments.
We still need to figure out the contexts in which TCA and ETC are needed in supporting metastasis, and how this may change in specific organ environments.
February 17, 2025 at 8:29 PM
6/We found that inhibiting complex I in the mitochondria was able to reduce metastatic dissemination in these models.
We still need to figure out the contexts in which TCA and ETC are needed in supporting metastasis, and how this may change in specific organ environments.
We still need to figure out the contexts in which TCA and ETC are needed in supporting metastasis, and how this may change in specific organ environments.
5/A limitation to studying metabolism directly in patients? It’s hard to test hypotheses.
So, we generated patient derived xenografts (PDXs)
These PDXs proved invaluable. They have similar metabolic properties to the patient tumor AND they spontaneously metastasize in NSG mice.
So, we generated patient derived xenografts (PDXs)
These PDXs proved invaluable. They have similar metabolic properties to the patient tumor AND they spontaneously metastasize in NSG mice.
February 17, 2025 at 8:26 PM
5/A limitation to studying metabolism directly in patients? It’s hard to test hypotheses.
So, we generated patient derived xenografts (PDXs)
These PDXs proved invaluable. They have similar metabolic properties to the patient tumor AND they spontaneously metastasize in NSG mice.
So, we generated patient derived xenografts (PDXs)
These PDXs proved invaluable. They have similar metabolic properties to the patient tumor AND they spontaneously metastasize in NSG mice.
4/This labeling pattern spans across other tumor features like histology and mutation. To borrow a phrase from Ralph and Matt, we think it’s a ‘convergent’ metabolic property.
Metabolite abundance alone did not predict survival. I think this underscores the value of using stable isotopes
Metabolite abundance alone did not predict survival. I think this underscores the value of using stable isotopes
February 17, 2025 at 8:24 PM
4/This labeling pattern spans across other tumor features like histology and mutation. To borrow a phrase from Ralph and Matt, we think it’s a ‘convergent’ metabolic property.
Metabolite abundance alone did not predict survival. I think this underscores the value of using stable isotopes
Metabolite abundance alone did not predict survival. I think this underscores the value of using stable isotopes
3/In this study, we found that most tumors had extensive 13C enrichment in TCA cycle metabolites.
Patients whose tumors had high 13C TCA cycle enrichment had worse survival outcomes than those with less enrichment.
Patients whose tumors had high 13C TCA cycle enrichment had worse survival outcomes than those with less enrichment.
February 17, 2025 at 8:23 PM
3/In this study, we found that most tumors had extensive 13C enrichment in TCA cycle metabolites.
Patients whose tumors had high 13C TCA cycle enrichment had worse survival outcomes than those with less enrichment.
Patients whose tumors had high 13C TCA cycle enrichment had worse survival outcomes than those with less enrichment.
2/ We use intra-operative infusions of 13C-labeled nutrients, like glucose, to study tumors
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
February 17, 2025 at 8:22 PM
2/ We use intra-operative infusions of 13C-labeled nutrients, like glucose, to study tumors
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
We’ve learned a lot with this approach. We saw that tumor metabolism can be very heterogeneous and that tumors use a variety of nutrients. Even so-called “waste” products are recycled by lung tumors.
Reposted by Brandon Faubert
Quietly renames “interesting papers to read in 2024” folder to “interesting papers to read in 2025” folder
December 19, 2024 at 3:25 AM
Quietly renames “interesting papers to read in 2024” folder to “interesting papers to read in 2025” folder