When bacteria evolve resistance to one antibiotic, they can become more vulnerable to another, a phenomenon called ‘hypersensitivity.’ We find antibiotics that leverage this, and emphasize the importance of the 'directionality' of hypersensitivities for improved therapies.

#AMR #microsky

"It’s as if every time you took a painkiller for your headache, you increased the chance that somebody else might have to undergo an operation without anaesthetic."

"It’s hard to imagine a more perfect anti-capitalist commodity than a product whose value depletes every time you use it."

#AMR

Pretty cool tool to visualize the cost of #AMR

Large scale experimental evolution can help identify trade-offs associated with antibiotic resistance that can have clinical relevance. We use multiple platforms to discover one such trade-off, and describe its mechanism in our report in IJAA.

🚨NEW PREPRINT ALERT:

In this paper, Jacob and Suzana from the Auclair lab investigate how Salmonella Typhimurium adapts to growing on itaconate, with detailed metabolic and genomic studies.

Many thanks to our collaborators at McGill and Concordia! (Details below) #chemsky

doi.org/10.1101/2025...

Compensatory evolution is a menace in the clinic, enabling maintenance of costly resistance determinants. We've built 3-drug evolutionary traps where bacteria compensate for the costs of resistance by reverting back to sensitivity!
#microsky

Online version missing whole figures, and pdf missing half of the figure captions. Scientific Reports 👌

Mutations in MMR (mismatch repair) genes do not predict an MMR phenotype, but a "trinucleotide mutational signature" does.

The idea of "evolution proof" antibiotics is cool, but it will probably remain an idea. We break an evolution proof antibiotic Tridecaptin in this paper. Improved lab evolution platforms will be crucial to help predict resistance.

#AMR #antibiotic #resistance