Arnaud Martin
@evolvwing.bsky.social
Associate Professor of Biology at the George Washington University
Interested in Pattern Formation, Evolutionary Tinkering, Genetics,
#lociofevolution #dnacrobatics #evodevo #lepidoptera
dnacrobatics.com
pubs: https://rb.gy/nfg8p
Interested in Pattern Formation, Evolutionary Tinkering, Genetics,
#lociofevolution #dnacrobatics #evodevo #lepidoptera
dnacrobatics.com
pubs: https://rb.gy/nfg8p
@royalsocietypublishing.org
@royalsociety.org
Greetings, is your journal server down? please let me know if this will fixed shortly or if there is a workaround, I need students to access Biology Letters for a class 🫶
Thanks!
@royalsociety.org
Greetings, is your journal server down? please let me know if this will fixed shortly or if there is a workaround, I need students to access Biology Letters for a class 🫶
Thanks!
November 10, 2025 at 6:23 PM
@royalsocietypublishing.org
@royalsociety.org
Greetings, is your journal server down? please let me know if this will fixed shortly or if there is a workaround, I need students to access Biology Letters for a class 🫶
Thanks!
@royalsociety.org
Greetings, is your journal server down? please let me know if this will fixed shortly or if there is a workaround, I need students to access Biology Letters for a class 🫶
Thanks!
Surely this table will help ;)
I don't see the interaction in example 2,
but it's late so please lmk
I don't see the interaction in example 2,
but it's late so please lmk
September 2, 2025 at 3:23 AM
Surely this table will help ;)
I don't see the interaction in example 2,
but it's late so please lmk
I don't see the interaction in example 2,
but it's late so please lmk
Transgenic Plodia larvae expressing the very bright mBaoJin (mStayGold variant) in its silk glands.
Also some gorgeous 3xP3:mCherry staining of larval ocelli and glia.
(see revised preprint) by pantry moth wizards
@donyaniyaz.bsky.social & @lucalivraghi.bsky.social doi.org/10.1101/2025...
Also some gorgeous 3xP3:mCherry staining of larval ocelli and glia.
(see revised preprint) by pantry moth wizards
@donyaniyaz.bsky.social & @lucalivraghi.bsky.social doi.org/10.1101/2025...
July 19, 2025 at 12:33 PM
Transgenic Plodia larvae expressing the very bright mBaoJin (mStayGold variant) in its silk glands.
Also some gorgeous 3xP3:mCherry staining of larval ocelli and glia.
(see revised preprint) by pantry moth wizards
@donyaniyaz.bsky.social & @lucalivraghi.bsky.social doi.org/10.1101/2025...
Also some gorgeous 3xP3:mCherry staining of larval ocelli and glia.
(see revised preprint) by pantry moth wizards
@donyaniyaz.bsky.social & @lucalivraghi.bsky.social doi.org/10.1101/2025...
Preprint alert from the lab
@jasminealqassar.bsky.social led this elegant study of gene expression in the silk glands of our favorite alternative "silk worm", the pantry moth.
Mega-polyploid cells with thousands of genome copies just to express a handful of proteins
doi.org/10.1101/2025...
@jasminealqassar.bsky.social led this elegant study of gene expression in the silk glands of our favorite alternative "silk worm", the pantry moth.
Mega-polyploid cells with thousands of genome copies just to express a handful of proteins
doi.org/10.1101/2025...
July 17, 2025 at 11:09 AM
Preprint alert from the lab
@jasminealqassar.bsky.social led this elegant study of gene expression in the silk glands of our favorite alternative "silk worm", the pantry moth.
Mega-polyploid cells with thousands of genome copies just to express a handful of proteins
doi.org/10.1101/2025...
@jasminealqassar.bsky.social led this elegant study of gene expression in the silk glands of our favorite alternative "silk worm", the pantry moth.
Mega-polyploid cells with thousands of genome copies just to express a handful of proteins
doi.org/10.1101/2025...
not quite, there this 1969 paper that observed some diffuse stripiness but definitely nothing like diptera salivary glands.
June 29, 2025 at 4:56 PM
not quite, there this 1969 paper that observed some diffuse stripiness but definitely nothing like diptera salivary glands.
Image above was from us in Plodia,
and here is a closely related species at an earlier stage
DOI: 10.1139/g2012-060
and here is a closely related species at an earlier stage
DOI: 10.1139/g2012-060
June 29, 2025 at 3:10 AM
Image above was from us in Plodia,
and here is a closely related species at an earlier stage
DOI: 10.1139/g2012-060
and here is a closely related species at an earlier stage
DOI: 10.1139/g2012-060
⭐ Can anyone guess what this is? ⭐
🔎 hints 🔍
- finding out will make your head spin!
- image ~ 100 um wide.
🔎 hints 🔍
- finding out will make your head spin!
- image ~ 100 um wide.
June 28, 2025 at 4:31 AM
⭐ Can anyone guess what this is? ⭐
🔎 hints 🔍
- finding out will make your head spin!
- image ~ 100 um wide.
🔎 hints 🔍
- finding out will make your head spin!
- image ~ 100 um wide.
Some of them with evidence of selective sweeps in a UV-polymorphic hybrid population, where we think UV presence-absence is under sexual selection
fin
fin
June 20, 2025 at 3:12 PM
Some of them with evidence of selective sweeps in a UV-polymorphic hybrid population, where we think UV presence-absence is under sexual selection
fin
fin
Many of them are likely targets of Bab repression, as suggested by ChIP-seq, including genes involved in cytoskeletal dynamics, secretion, and chitin modification
10/n
10/n
June 20, 2025 at 3:12 PM
Many of them are likely targets of Bab repression, as suggested by ChIP-seq, including genes involved in cytoskeletal dynamics, secretion, and chitin modification
10/n
10/n
which means we have now a full list of candidate gene that are specific to these incredible nano-optical technology building cell types in the future ...
9/n
9/n
June 20, 2025 at 3:12 PM
which means we have now a full list of candidate gene that are specific to these incredible nano-optical technology building cell types in the future ...
9/n
9/n
Sifting through new markers, we found that special UV-iridescent scales were Cluster 3:
Bab and Doublesex OFF
Abp1 and Sulfatase1 ON
8/n
Bab and Doublesex OFF
Abp1 and Sulfatase1 ON
8/n
June 20, 2025 at 3:12 PM
Sifting through new markers, we found that special UV-iridescent scales were Cluster 3:
Bab and Doublesex OFF
Abp1 and Sulfatase1 ON
8/n
Bab and Doublesex OFF
Abp1 and Sulfatase1 ON
8/n
Next, we wondered if given their unique morphology the UV scales cells have the signature of a distinct cell type.
The answer was a resounding YES
Single-nucleus transcriptomics recovered a few scale types including hair-like scales, regular orange or black scales, and 2 male-specific types
6/n
The answer was a resounding YES
Single-nucleus transcriptomics recovered a few scale types including hair-like scales, regular orange or black scales, and 2 male-specific types
6/n
June 20, 2025 at 3:12 PM
Next, we wondered if given their unique morphology the UV scales cells have the signature of a distinct cell type.
The answer was a resounding YES
Single-nucleus transcriptomics recovered a few scale types including hair-like scales, regular orange or black scales, and 2 male-specific types
6/n
The answer was a resounding YES
Single-nucleus transcriptomics recovered a few scale types including hair-like scales, regular orange or black scales, and 2 male-specific types
6/n
So how Bab is itself repressed in males to allow UV-scales?
Well, to our greatest surprise, it's not: the male state w/ Bab absent every other scale (thus allowing UV) is the default
And instead, females need the Doublesex gene to activate Bab!
crazy CRISPR KOs below (+ IF and RNAi in pape)
5/n
Well, to our greatest surprise, it's not: the male state w/ Bab absent every other scale (thus allowing UV) is the default
And instead, females need the Doublesex gene to activate Bab!
crazy CRISPR KOs below (+ IF and RNAi in pape)
5/n
June 20, 2025 at 3:12 PM
So how Bab is itself repressed in males to allow UV-scales?
Well, to our greatest surprise, it's not: the male state w/ Bab absent every other scale (thus allowing UV) is the default
And instead, females need the Doublesex gene to activate Bab!
crazy CRISPR KOs below (+ IF and RNAi in pape)
5/n
Well, to our greatest surprise, it's not: the male state w/ Bab absent every other scale (thus allowing UV) is the default
And instead, females need the Doublesex gene to activate Bab!
crazy CRISPR KOs below (+ IF and RNAi in pape)
5/n
Our previous study had shown that there is an developmental off switch for this : expression of the transcription factor Bric-a-Brac (bab) blocks the differentiation of UV scales
doi.org/10.1073/pnas...
4/n
doi.org/10.1073/pnas...
4/n
June 20, 2025 at 3:12 PM
Our previous study had shown that there is an developmental off switch for this : expression of the transcription factor Bric-a-Brac (bab) blocks the differentiation of UV scales
doi.org/10.1073/pnas...
4/n
doi.org/10.1073/pnas...
4/n
which is made by male specific ultraviolet-iridescent scales with incredible nanostructures on them
3/n
3/n
June 20, 2025 at 3:12 PM
which is made by male specific ultraviolet-iridescent scales with incredible nanostructures on them
3/n
3/n
Male Orange Sulphur butterflies (Colias eurytheme) use bright ultraviolet flashes during courtship
2/n
2/n
June 20, 2025 at 3:12 PM
Male Orange Sulphur butterflies (Colias eurytheme) use bright ultraviolet flashes during courtship
2/n
2/n
I love this SO MUCH... the plate specific neuronal driver, membrane+nuclear labelling, and the overlay with cuticle autofluorescence.... oooomph!!!
(PS: red->magenta works better for some people in my lab)
(PS: red->magenta works better for some people in my lab)
May 19, 2025 at 4:19 PM
I love this SO MUCH... the plate specific neuronal driver, membrane+nuclear labelling, and the overlay with cuticle autofluorescence.... oooomph!!!
(PS: red->magenta works better for some people in my lab)
(PS: red->magenta works better for some people in my lab)
Awesome new paper by @lucalivraghi.bsky.social et al.
doi.org/10.1016/j.cu...
in @currentbiology.bsky.social
on the evo-devo of a butterfly color variation
enjoy the show!
doi.org/10.1016/j.cu...
in @currentbiology.bsky.social
on the evo-devo of a butterfly color variation
enjoy the show!
April 14, 2025 at 2:53 AM
Awesome new paper by @lucalivraghi.bsky.social et al.
doi.org/10.1016/j.cu...
in @currentbiology.bsky.social
on the evo-devo of a butterfly color variation
enjoy the show!
doi.org/10.1016/j.cu...
in @currentbiology.bsky.social
on the evo-devo of a butterfly color variation
enjoy the show!
Yea they're super judgy but their babies less so
April 10, 2025 at 8:42 PM
Yea they're super judgy but their babies less so
Preprint! Minos-mediated transgenesis in the pantry moth
www.biorxiv.org/content/10.1...
By @donyaniyaz.bsky.social
www.biorxiv.org/content/10.1...
By @donyaniyaz.bsky.social
April 5, 2025 at 6:45 AM
Preprint! Minos-mediated transgenesis in the pantry moth
www.biorxiv.org/content/10.1...
By @donyaniyaz.bsky.social
www.biorxiv.org/content/10.1...
By @donyaniyaz.bsky.social
