The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Activation of PNOCARC neurons promotes feeding. Here, Solheim et al. describe PNOC neurons in the murine ARC as mediators of leptin action in body weight maintenance. Moreover, they molecularly and functionally define a specific PNOCARC subtype, characterized by co-expression of PNOC and NPY, which is conserved in humans and regulates feeding in mice.

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

Multi-modal transcriptomic analyses of the sympathetic nervous system reveal organ-specific neural innervation and modular regulation of visceral functions.