Thank you for sharing! Very interesting development

The craziness is back …😢…
Gulf of America 😂
January 20, Independence Day 😂
State of emergency, but this time Mexico will not pay for it 😂
I will it was just a stand up comedian performing

Congratulations Juliane!👏
I am very happy to see this 😍😍

Good to see how people are helpful

Thank you Max!
Yes, I am doing well! I hope all is well on your side!

This work would not have been possible without the dedication my team and collaborators. A heartfelt Thank you and congratulations to everyone involved!
#hematopoiesis #AML #science #CRISPR #epigenomics

5) Clinical Relevance: XACT expression in a subset of AML patients, combined with its exclusive expression in myeloid progenitors, points to its potential as a marker for AML subtypes.

4)Functional Insights: CRISPR-based XACT perturbation, along with epigenomic and transcriptomic studies, reveals XACT’s crucial role in regulating erythroid progenitor self-renewal and differentiation by modulating transcription

3.1) Interestingly, this new XACT transcript that we discovered in the erythroleukemic K562 cell line and is also expressed in a subset of acute myeloid leukemia (AML) patients.

3) Expression during differentiation and cancer: During hematopoiesis, XACT exhibits a distinct expression pattern specific to myeloid progenitors.

2) This new XACT transcript is present on both the inactive (Xi) and active (Xa) X-chromosomes, coexisting with XIST on the Xi. However, it does not affect XIST expression or (re)activate X-linked genes silenced by the X-chromosome inactivation mechanism.

Key Highlights:
1) A novel discovery: We discovered a new XACT lncRNA transcript expressed in normal and cancerous somatic cells of both sexes.