Elliott Rees
@erees85.bsky.social
Researcher in psychiatric genetics at Cardiff University
Reposted by Elliott Rees
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Setd1a Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
AbstractBackground and Hypothesis. SETD1A, a histone methyltransferase, is implicated in schizophrenia through rare loss-of-function mutations. While SETD1
doi.org
June 12, 2025 at 11:20 AM
New paper in @oxfordacademic.bsky.social Schizophrenia Bulletin exploring the effects of Setd1a happloinsufficiency on DNA methylation in the frontal cortex. Strong effects on the regulation of ribosomal genes with implications for understanding the genetics of schizophrenia. doi.org/10.1093/schb...
Reposted by Elliott Rees
Really excited, exhausted and relieved to finally be able to share the results from an analysis of the @GenomicsEngland 100,000 Genomes Project dataset.
Here's a link to free access to the manuscript:
authors.elsevier.com/a/1l8iU3vlFV...
see below 🧵for main outcomes
Here's a link to free access to the manuscript:
authors.elsevier.com/a/1l8iU3vlFV...
see below 🧵for main outcomes
authors.elsevier.com
May 27, 2025 at 3:10 PM
Really excited, exhausted and relieved to finally be able to share the results from an analysis of the @GenomicsEngland 100,000 Genomes Project dataset.
Here's a link to free access to the manuscript:
authors.elsevier.com/a/1l8iU3vlFV...
see below 🧵for main outcomes
Here's a link to free access to the manuscript:
authors.elsevier.com/a/1l8iU3vlFV...
see below 🧵for main outcomes
New preprint from the group! New exome seq data and novel rare variant associations. Led by the brilliant Sophie Chick www.medrxiv.org/content/10.1...
Analysis of exome sequencing data implicates rare coding variants in STAG1 and ZNF136 in schizophrenia
Rare coding variants across many genes contribute to schizophrenia liability, but they have only been implicated in 12 genes at exome-wide levels of significance. To increase power for gene discovery,...
www.medrxiv.org
October 22, 2024 at 3:38 PM
New preprint from the group! New exome seq data and novel rare variant associations. Led by the brilliant Sophie Chick www.medrxiv.org/content/10.1...